Fatal hepatotoxicity secondary to nimesulide

This report describes a 57-year-old female patient with chronic lumbago, who died from the sequelae of acute liver failure induced by nimesulide medication. Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) which preferentially inhibits cyclo-oxygenase 2 and has been associated with a tot...

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Veröffentlicht in:European journal of clinical pharmacology Jg. 57; H. 4; S. 321 - 326
Hauptverfasser: Merlani, Giorgio, Fox, Mark, Oehen, Hans-Peter, Cathomas, Gieri, Renner, Eberhard L., Fattinger, Karin, Schneemann, Markus, Kullak-Ublick, Gerd A.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Heidelberg Springer 01.07.2001
Berlin Springer Nature B.V
Schlagworte:
Biological and medical sciences
Drug toxicity and drugs side effects treatment
Liver
Medical sciences
Pharmacology. Drug treatments
Side effects
Toxicity: digestive system
Human
Prostaglandin-endoperoxide synthase
Enzyme
Isozyme
Toxicity
Liver
Enzyme inhibitor
Hepatic disease
Non steroidal antiinflammatory agent
Case study
Digestive diseases
Death
Oxidoreductases
Nimesulide
ISSN:0031-6970, 1432-1041
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Abstract This report describes a 57-year-old female patient with chronic lumbago, who died from the sequelae of acute liver failure induced by nimesulide medication. Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) which preferentially inhibits cyclo-oxygenase 2 and has been associated with a total of 13 reported cases of severe liver injury including our case. On the basis of the literature reports, the following features of nimesulide-associated hepatotoxicity were identified: female sex (84% of cases), age (mean age 62 years), jaundice as a primary manifestation (90%) and the absence of peripheral blood eosinophilia. The average duration of therapy of the published cases was 62 days (range 7-180 days). Based on spontaneous reports to the World Health Organization, nimesulide induces a high proportion of severe adverse hepatic reactions compared with other NSAIDs registered in Switzerland. Hepatotoxicity thus represents an important risk factor of nimesulide usage.[PUBLICATION ABSTRACT]
AbstractList This report describes a 57-year-old female patient with chronic lumbago, who died from the sequelae of acute liver failure induced by nimesulide medication. Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) which preferentially inhibits cyclo-oxygenase 2 and has been associated with a total of 13 reported cases of severe liver injury including our case. On the basis of the literature reports, the following features of nimesulide-associated hepatotoxicity were identified: female sex (84% of cases), age (mean age 62 years), jaundice as a primary manifestation (90%) and the absence of peripheral blood eosinophilia. The average duration of therapy of the published cases was 62 days (range 7-180 days). Based on spontaneous reports to the World Health Organization, nimesulide induces a high proportion of severe adverse hepatic reactions compared with other NSAIDs registered in Switzerland. Hepatotoxicity thus represents an important risk factor of nimesulide usage.[PUBLICATION ABSTRACT]
This report describes a 57-year-old female patient with chronic lumbago, who died from the sequelae of acute liver failure induced by nimesulide medication. Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) which preferentially inhibits cyclo-oxygenase 2 and has been associated with a total of 13 reported cases of severe liver injury including our case. On the basis of the literature reports, the following features of nimesulide-associated hepatotoxicity were identified: female sex (84% of cases), age (mean age 62 years), jaundice as a primary manifestation (90%) and the absence of peripheral blood eosinophilia. The average duration of therapy of the published cases was 62 days (range 7-180 days). Based on spontaneous reports to the World Health Organization, nimesulide induces a high proportion of severe adverse hepatic reactions compared with other NSAIDs registered in Switzerland. Hepatotoxicity thus represents an important risk factor of nimesulide usage.
Author Oehen, Hans-Peter
Fox, Mark
Merlani, Giorgio
Renner, Eberhard L.
Fattinger, Karin
Schneemann, Markus
Cathomas, Gieri
Kullak-Ublick, Gerd A.
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  givenname: Giorgio
  surname: Merlani
  fullname: Merlani, Giorgio
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  givenname: Mark
  surname: Fox
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  givenname: Hans-Peter
  surname: Oehen
  fullname: Oehen, Hans-Peter
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  givenname: Gieri
  surname: Cathomas
  fullname: Cathomas, Gieri
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  givenname: Eberhard L.
  surname: Renner
  fullname: Renner, Eberhard L.
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  givenname: Karin
  surname: Fattinger
  fullname: Fattinger, Karin
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  givenname: Markus
  surname: Schneemann
  fullname: Schneemann, Markus
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  givenname: Gerd A.
  surname: Kullak-Ublick
  fullname: Kullak-Ublick, Gerd A.
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Keywords Human
Prostaglandin-endoperoxide synthase
Enzyme
Isozyme
Toxicity
Liver
Enzyme inhibitor
Hepatic disease
Non steroidal antiinflammatory agent
Case study
Digestive diseases
Death
Oxidoreductases
Nimesulide
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Snippet This report describes a 57-year-old female patient with chronic lumbago, who died from the sequelae of acute liver failure induced by nimesulide medication....
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SubjectTerms Biological and medical sciences
Drug toxicity and drugs side effects treatment
Liver
Medical sciences
Pharmacology. Drug treatments
Side effects
Toxicity: digestive system
Title Fatal hepatotoxicity secondary to nimesulide
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