Fatal hepatotoxicity secondary to nimesulide

This report describes a 57-year-old female patient with chronic lumbago, who died from the sequelae of acute liver failure induced by nimesulide medication. Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) which preferentially inhibits cyclo-oxygenase 2 and has been associated with a tot...

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Bibliographic Details
Published in:European journal of clinical pharmacology Vol. 57; no. 4; pp. 321 - 326
Main Authors: Merlani, Giorgio, Fox, Mark, Oehen, Hans-Peter, Cathomas, Gieri, Renner, Eberhard L., Fattinger, Karin, Schneemann, Markus, Kullak-Ublick, Gerd A.
Format: Journal Article
Language:English
Published: Heidelberg Springer 01.07.2001
Berlin Springer Nature B.V
Subjects:
Biological and medical sciences
Drug toxicity and drugs side effects treatment
Liver
Medical sciences
Pharmacology. Drug treatments
Side effects
Toxicity: digestive system
Human
Prostaglandin-endoperoxide synthase
Enzyme
Isozyme
Toxicity
Liver
Enzyme inhibitor
Hepatic disease
Non steroidal antiinflammatory agent
Case study
Digestive diseases
Death
Oxidoreductases
Nimesulide
ISSN:0031-6970, 1432-1041
Online Access:Get full text
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Summary:This report describes a 57-year-old female patient with chronic lumbago, who died from the sequelae of acute liver failure induced by nimesulide medication. Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) which preferentially inhibits cyclo-oxygenase 2 and has been associated with a total of 13 reported cases of severe liver injury including our case. On the basis of the literature reports, the following features of nimesulide-associated hepatotoxicity were identified: female sex (84% of cases), age (mean age 62 years), jaundice as a primary manifestation (90%) and the absence of peripheral blood eosinophilia. The average duration of therapy of the published cases was 62 days (range 7-180 days). Based on spontaneous reports to the World Health Organization, nimesulide induces a high proportion of severe adverse hepatic reactions compared with other NSAIDs registered in Switzerland. Hepatotoxicity thus represents an important risk factor of nimesulide usage.[PUBLICATION ABSTRACT]
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ISSN:0031-6970
1432-1041
DOI:10.1007/s002280100312