Fatal hepatotoxicity secondary to nimesulide

This report describes a 57-year-old female patient with chronic lumbago, who died from the sequelae of acute liver failure induced by nimesulide medication. Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) which preferentially inhibits cyclo-oxygenase 2 and has been associated with a tot...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:European journal of clinical pharmacology Jg. 57; H. 4; S. 321 - 326
Hauptverfasser: Merlani, Giorgio, Fox, Mark, Oehen, Hans-Peter, Cathomas, Gieri, Renner, Eberhard L., Fattinger, Karin, Schneemann, Markus, Kullak-Ublick, Gerd A.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Heidelberg Springer 01.07.2001
Berlin Springer Nature B.V
Schlagworte:
Biological and medical sciences
Drug toxicity and drugs side effects treatment
Liver
Medical sciences
Pharmacology. Drug treatments
Side effects
Toxicity: digestive system
Human
Prostaglandin-endoperoxide synthase
Enzyme
Isozyme
Toxicity
Liver
Enzyme inhibitor
Hepatic disease
Non steroidal antiinflammatory agent
Case study
Digestive diseases
Death
Oxidoreductases
Nimesulide
ISSN:0031-6970, 1432-1041
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:This report describes a 57-year-old female patient with chronic lumbago, who died from the sequelae of acute liver failure induced by nimesulide medication. Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) which preferentially inhibits cyclo-oxygenase 2 and has been associated with a total of 13 reported cases of severe liver injury including our case. On the basis of the literature reports, the following features of nimesulide-associated hepatotoxicity were identified: female sex (84% of cases), age (mean age 62 years), jaundice as a primary manifestation (90%) and the absence of peripheral blood eosinophilia. The average duration of therapy of the published cases was 62 days (range 7-180 days). Based on spontaneous reports to the World Health Organization, nimesulide induces a high proportion of severe adverse hepatic reactions compared with other NSAIDs registered in Switzerland. Hepatotoxicity thus represents an important risk factor of nimesulide usage.[PUBLICATION ABSTRACT]
Bibliographie:ObjectType-Case Study-3
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 14
ObjectType-Report-2
ObjectType-Article-2
content type line 23
ISSN:0031-6970
1432-1041
DOI:10.1007/s002280100312