miR-731 modulates the zebrafish heart morphogenesis via targeting Calcineurin/Nfatc3a pathway

Zebrafish miR-731 is orthologous of human miR-425, which has been demonstrated to have cardio-protective roles by a variety of mechanisms. The miR-731 morphants show pericardium enlargement, and many DEGs (differentially expressed genes) are enriched in ‘Cardiac muscle contraction’ and ‘Calcium sign...

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Bibliographic Details
Published in:	Biochimica et biophysica acta. General subjects Vol. 1866; no. 6; p. 130133
Main Authors:	Huang, Yan, Wang, Wei-Feng, Huang, Chun-Xiao, Li, Xuan-Hui, Liu, Hong, Wang, Huan-Ling
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.06.2022
Subjects:	Animals Calcineurin - genetics Calcineurin - metabolism Calcineurin/Nfatc3a calcium cardiac output Danio rerio Development gene expression gene expression regulation genes Heart heart rate humans hybridization luciferase MicroRNAs - genetics MicroRNAs - metabolism miR-731 morphogenesis Morphogenesis - genetics muscle contraction myocardium pericardium sequence analysis Western blotting Zebrafish Zebrafish - genetics Zebrafish - metabolism Zebrafish Proteins - genetics Heart Development Calcineurin/Nfatc3a Zebrafish miR-731
ISSN:	0304-4165, 1872-8006, 1872-8006
Online Access:	Get full text
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