Bioresorbable shape-adaptive structures for ultrasonic monitoring of deep-tissue homeostasis

Monitoring homeostasis is an essential aspect of obtaining pathophysiological insights for treating patients. Accurate, timely assessments of homeostatic dysregulation in deep tissues typically require expensive imaging techniques or invasive biopsies. We introduce a bioresorbable shape-adaptive mat...

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Veröffentlicht in:Science (American Association for the Advancement of Science) Jg. 383; H. 6687; S. 1096
Hauptverfasser: Liu, Jiaqi, Liu, Naijia, Xu, Yameng, Wu, Mingzheng, Zhang, Haohui, Wang, Yue, Yan, Ying, Hill, Angela, Song, Ruihao, Xu, Zijie, Park, Minsu, Wu, Yunyun, Ciatti, Joanna L, Gu, Jianyu, Luan, Haiwen, Zhang, Yamin, Yang, Tianyu, Ahn, Hak-Young, Li, Shupeng, Ray, Wilson Z, Franz, Colin K, MacEwan, Matthew R, Huang, Yonggang, Hammill, Chet W, Wang, Heling, Rogers, John A
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 08.03.2024
Schlagworte:
Absorbable Implants
Anastomotic Leak - diagnostic imaging
Animals
Gastrointestinal Tract - surgery
Homeostasis
Humans
Models, Animal
Stomach
Ultrasonics
ISSN:1095-9203, 1095-9203
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Zusammenfassung:Monitoring homeostasis is an essential aspect of obtaining pathophysiological insights for treating patients. Accurate, timely assessments of homeostatic dysregulation in deep tissues typically require expensive imaging techniques or invasive biopsies. We introduce a bioresorbable shape-adaptive materials structure that enables real-time monitoring of deep-tissue homeostasis using conventional ultrasound instruments. Collections of small bioresorbable metal disks distributed within thin, pH-responsive hydrogels, deployed by surgical implantation or syringe injection, allow ultrasound-based measurements of spatiotemporal changes in pH for early assessments of anastomotic leaks after gastrointestinal surgeries, and their bioresorption after a recovery period eliminates the need for surgical extraction. Demonstrations in small and large animal models illustrate capabilities in monitoring leakage from the small intestine, the stomach, and the pancreas.
Bibliographie:ObjectType-Article-1
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ISSN:1095-9203
1095-9203
DOI:10.1126/science.adk9880