Bioresorbable shape-adaptive structures for ultrasonic monitoring of deep-tissue homeostasis
Monitoring homeostasis is an essential aspect of obtaining pathophysiological insights for treating patients. Accurate, timely assessments of homeostatic dysregulation in deep tissues typically require expensive imaging techniques or invasive biopsies. We introduce a bioresorbable shape-adaptive mat...
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| Published in: | Science (American Association for the Advancement of Science) Vol. 383; no. 6687; p. 1096 |
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
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United States
08.03.2024
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| ISSN: | 1095-9203, 1095-9203 |
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| Abstract | Monitoring homeostasis is an essential aspect of obtaining pathophysiological insights for treating patients. Accurate, timely assessments of homeostatic dysregulation in deep tissues typically require expensive imaging techniques or invasive biopsies. We introduce a bioresorbable shape-adaptive materials structure that enables real-time monitoring of deep-tissue homeostasis using conventional ultrasound instruments. Collections of small bioresorbable metal disks distributed within thin, pH-responsive hydrogels, deployed by surgical implantation or syringe injection, allow ultrasound-based measurements of spatiotemporal changes in pH for early assessments of anastomotic leaks after gastrointestinal surgeries, and their bioresorption after a recovery period eliminates the need for surgical extraction. Demonstrations in small and large animal models illustrate capabilities in monitoring leakage from the small intestine, the stomach, and the pancreas. |
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| AbstractList | Monitoring homeostasis is an essential aspect of obtaining pathophysiological insights for treating patients. Accurate, timely assessments of homeostatic dysregulation in deep tissues typically require expensive imaging techniques or invasive biopsies. We introduce a bioresorbable shape-adaptive materials structure that enables real-time monitoring of deep-tissue homeostasis using conventional ultrasound instruments. Collections of small bioresorbable metal disks distributed within thin, pH-responsive hydrogels, deployed by surgical implantation or syringe injection, allow ultrasound-based measurements of spatiotemporal changes in pH for early assessments of anastomotic leaks after gastrointestinal surgeries, and their bioresorption after a recovery period eliminates the need for surgical extraction. Demonstrations in small and large animal models illustrate capabilities in monitoring leakage from the small intestine, the stomach, and the pancreas. Monitoring homeostasis is an essential aspect of obtaining pathophysiological insights for treating patients. Accurate, timely assessments of homeostatic dysregulation in deep tissues typically require expensive imaging techniques or invasive biopsies. We introduce a bioresorbable shape-adaptive materials structure that enables real-time monitoring of deep-tissue homeostasis using conventional ultrasound instruments. Collections of small bioresorbable metal disks distributed within thin, pH-responsive hydrogels, deployed by surgical implantation or syringe injection, allow ultrasound-based measurements of spatiotemporal changes in pH for early assessments of anastomotic leaks after gastrointestinal surgeries, and their bioresorption after a recovery period eliminates the need for surgical extraction. Demonstrations in small and large animal models illustrate capabilities in monitoring leakage from the small intestine, the stomach, and the pancreas.Monitoring homeostasis is an essential aspect of obtaining pathophysiological insights for treating patients. Accurate, timely assessments of homeostatic dysregulation in deep tissues typically require expensive imaging techniques or invasive biopsies. We introduce a bioresorbable shape-adaptive materials structure that enables real-time monitoring of deep-tissue homeostasis using conventional ultrasound instruments. Collections of small bioresorbable metal disks distributed within thin, pH-responsive hydrogels, deployed by surgical implantation or syringe injection, allow ultrasound-based measurements of spatiotemporal changes in pH for early assessments of anastomotic leaks after gastrointestinal surgeries, and their bioresorption after a recovery period eliminates the need for surgical extraction. Demonstrations in small and large animal models illustrate capabilities in monitoring leakage from the small intestine, the stomach, and the pancreas. |
| Author | Ray, Wilson Z MacEwan, Matthew R Ahn, Hak-Young Liu, Naijia Franz, Colin K Wang, Heling Wu, Mingzheng Zhang, Yamin Zhang, Haohui Xu, Yameng Hammill, Chet W Xu, Zijie Luan, Haiwen Park, Minsu Huang, Yonggang Wu, Yunyun Ciatti, Joanna L Yan, Ying Wang, Yue Li, Shupeng Rogers, John A Gu, Jianyu Liu, Jiaqi Hill, Angela Song, Ruihao Yang, Tianyu |
| Author_xml | – sequence: 1 givenname: Jiaqi orcidid: 0000-0002-5587-7243 surname: Liu fullname: Liu, Jiaqi organization: Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA – sequence: 2 givenname: Naijia orcidid: 0000-0003-4705-2927 surname: Liu fullname: Liu, Naijia organization: Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA – sequence: 3 givenname: Yameng surname: Xu fullname: Xu, Yameng organization: Department of Neurosurgery, Washington University School of Medicine, St. Louis, MO 63110, USA – sequence: 4 givenname: Mingzheng orcidid: 0000-0003-4415-6296 surname: Wu fullname: Wu, Mingzheng organization: Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA – sequence: 5 givenname: Haohui orcidid: 0000-0001-8432-3672 surname: Zhang fullname: Zhang, Haohui organization: Department of Civil and Environmental Engineering, Northwestern University, Evanston, IL 60208, USA – sequence: 6 givenname: Yue orcidid: 0000-0002-9763-3570 surname: Wang fullname: Wang, Yue organization: Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA – sequence: 7 givenname: Ying surname: Yan fullname: Yan, Ying organization: Department of Neurosurgery, Washington University School of Medicine, St. Louis, MO 63110, USA – sequence: 8 givenname: Angela surname: Hill fullname: Hill, Angela organization: Department of Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA – sequence: 9 givenname: Ruihao surname: Song fullname: Song, Ruihao organization: Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL 60208, USA – sequence: 10 givenname: Zijie surname: Xu fullname: Xu, Zijie organization: Department of Materials Science and Engineering, Northwestern University, Evanston, IL 60208, USA – sequence: 11 givenname: Minsu orcidid: 0000-0003-0759-8888 surname: Park fullname: Park, Minsu organization: Department of Polymer Science and Engineering, Dankook University, Yongin 16890, Republic of Korea – sequence: 12 givenname: Yunyun surname: Wu fullname: Wu, Yunyun organization: Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA – sequence: 13 givenname: Joanna L orcidid: 0000-0001-5393-522X surname: Ciatti fullname: Ciatti, Joanna L organization: Department of Materials Science and Engineering, Northwestern University, Evanston, IL 60208, USA – sequence: 14 givenname: Jianyu surname: Gu fullname: Gu, Jianyu organization: Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA – sequence: 15 givenname: Haiwen orcidid: 0000-0003-0722-1108 surname: Luan fullname: Luan, Haiwen organization: Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA – sequence: 16 givenname: Yamin orcidid: 0000-0003-4890-1265 surname: Zhang fullname: Zhang, Yamin organization: Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA – sequence: 17 givenname: Tianyu surname: Yang fullname: Yang, Tianyu organization: Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA – sequence: 18 givenname: Hak-Young orcidid: 0000-0002-5441-1054 surname: Ahn fullname: Ahn, Hak-Young organization: Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA – sequence: 19 givenname: Shupeng orcidid: 0000-0002-8723-9369 surname: Li fullname: Li, Shupeng organization: Department of Mechanical Engineering, Northwestern University, Evanston, IL 60208, USA – sequence: 20 givenname: Wilson Z surname: Ray fullname: Ray, Wilson Z organization: Department of Neurosurgery, Washington University School of Medicine, St. Louis, MO 63110, USA – sequence: 21 givenname: Colin K orcidid: 0000-0003-4546-8638 surname: Franz fullname: Franz, Colin K organization: The Ken and Ruth Davee Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA – sequence: 22 givenname: Matthew R orcidid: 0000-0002-7911-3408 surname: MacEwan fullname: MacEwan, Matthew R organization: Department of Neurosurgery, Washington University School of Medicine, St. Louis, MO 63110, USA – sequence: 23 givenname: Yonggang orcidid: 0000-0002-0483-8359 surname: Huang fullname: Huang, Yonggang organization: Department of Mechanical Engineering, Northwestern University, Evanston, IL 60208, USA – sequence: 24 givenname: Chet W orcidid: 0000-0001-9749-0824 surname: Hammill fullname: Hammill, Chet W organization: Department of Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA – sequence: 25 givenname: Heling orcidid: 0000-0001-7859-5153 surname: Wang fullname: Wang, Heling organization: Institute of Flexible Electronics Technology of THU Zhejiang, Jiaxing 314000, China – sequence: 26 givenname: John A orcidid: 0000-0002-3830-5980 surname: Rogers fullname: Rogers, John A organization: Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA |
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| SubjectTerms | Absorbable Implants Anastomotic Leak - diagnostic imaging Animals Gastrointestinal Tract - surgery Homeostasis Humans Models, Animal Stomach Ultrasonics |
| Title | Bioresorbable shape-adaptive structures for ultrasonic monitoring of deep-tissue homeostasis |
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