Exploring the impact of ethnicity on drug pharmacokinetics using PBPK models: A case study with lansoprazole in Japanese subjects

Aims The aim of this study is to demonstrate the use of PBPK modelling to explore the impact of ethnic differences on drug PK. Methods A PBPK model developed for lansoprazole was used to predict the clinical PK of lansoprazole in Japanese subjects by incorporating the physiological parameters of a J...

Full description

Saved in:

Bibliographic Details
Published in:	British journal of clinical pharmacology Vol. 91; no. 4; pp. 1016 - 1030
Main Authors:	Ezuruike, Udoamaka, Curry, Liam, Hatley, Oliver, Gardner, Iain
Format:	Journal Article
Language:	English
Published:	England 01.04.2025
Subjects:	2-Pyridinylmethylsulfinylbenzimidazoles - pharmacokinetics Administration, Oral Adult Area Under Curve Computer Simulation cytochrome P450 enzymes East Asian People Female genetic polymorphism Humans Japan Lansoprazole - pharmacokinetics Male Middle Aged Models, Biological PBPK pharmacokinetics Proton Pump Inhibitors - pharmacokinetics White People Young Adult Japan PBPK pharmacokinetics genetic polymorphism cytochrome P450 enzymes
ISSN:	0306-5251, 1365-2125, 1365-2125
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!