Exploring the impact of ethnicity on drug pharmacokinetics using PBPK models: A case study with lansoprazole in Japanese subjects

Aims The aim of this study is to demonstrate the use of PBPK modelling to explore the impact of ethnic differences on drug PK. Methods A PBPK model developed for lansoprazole was used to predict the clinical PK of lansoprazole in Japanese subjects by incorporating the physiological parameters of a J...

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Vydáno v:	British journal of clinical pharmacology Ročník 91; číslo 4; s. 1016 - 1030
Hlavní autoři:	Ezuruike, Udoamaka, Curry, Liam, Hatley, Oliver, Gardner, Iain
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England 01.04.2025
Témata:	2-Pyridinylmethylsulfinylbenzimidazoles - pharmacokinetics Administration, Oral Adult Area Under Curve Computer Simulation cytochrome P450 enzymes East Asian People Female genetic polymorphism Humans Japan Lansoprazole - pharmacokinetics Male Middle Aged Models, Biological PBPK pharmacokinetics Proton Pump Inhibitors - pharmacokinetics White People Young Adult Japan PBPK pharmacokinetics genetic polymorphism cytochrome P450 enzymes
ISSN:	0306-5251, 1365-2125, 1365-2125
On-line přístup:	Získat plný text
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