Modelling and optimizing combination therapeutic strategies for KRAS- and EGFR-mutant lung cancer

Non-small cell lung carcinoma (NSCLC) is well-known for its high incidence (about 80% of lung cancer) and genetic heterogeneity. Personalized driver mutations such as EGFR and KRAS have established targeted therapies with kinase inhibitors, whereas immune checkpoint inhibitors (ICIs) have revolution...

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Bibliographic Details
Published in:	Journal of bioinformatics and computational biology Vol. 23; no. 5; p. 2550017
Main Authors:	Wu, Lanqi, Yu, Ruocheng, Yao, Minghui, Rahaman, Md Matiur, Fang, Zhaoyuan
Format:	Journal Article
Language:	English
Published:	Singapore 01.10.2025
Subjects:	Animals Antineoplastic Combined Chemotherapy Protocols - therapeutic use Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - genetics ErbB Receptors - antagonists & inhibitors ErbB Receptors - genetics Humans Immune Checkpoint Inhibitors - therapeutic use Lung Neoplasms - drug therapy Lung Neoplasms - genetics Mice Mutation Protein Kinase Inhibitors - therapeutic use Proto-Oncogene Proteins p21(ras) - antagonists & inhibitors Proto-Oncogene Proteins p21(ras) - genetics combined therapy targeted therapy Lung cancer Boolean networks immunotherapy
ISSN:	1757-6334, 1757-6334
Online Access:	Get more information
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