A platinum complex that binds non-covalently to DNA and induces cell death via a different mechanism than cisplatin

Cisplatin and some of its derivatives have been shown to be very successful anticancer agents. Their main mode of action has been proposed to be via covalent binding to DNA. However, one of the limitations of these drugs is their poor activity against some tumours due to intrinsic or acquired resist...

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Bibliographic Details
Published in:	Metallomics Vol. 5; no. 5; p. 514
Main Authors:	Suntharalingam, Kogularamanan, Mendoza, Oscar, Duarte, Alexandra A, Mann, David J, Vilar, Ramon
Format:	Journal Article
Language:	English
Published:	England 01.05.2013
Subjects:	Animals Cattle Cell Cycle - drug effects Cell Death - drug effects Cell Line, Tumor Chemical Precipitation Cisplatin - chemistry Cisplatin - pharmacology DNA - metabolism Humans Inhibitory Concentration 50 Mice Molecular Docking Simulation NIH 3T3 Cells Organoplatinum Compounds - chemistry Organoplatinum Compounds - metabolism Organoplatinum Compounds - pharmacology Phagocytosis - drug effects Platinum - chemistry Platinum - metabolism Platinum - pharmacology
ISSN:	1756-591X, 1756-591X
Online Access:	Get more information
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