16-Channel Integrated Potentiostat for Distributed Neurochemical Sensing

We present the architecture and VLSI circuit implementation of a BiCMOS potentiostat bank for monitoring neurotransmitter concentration on a screen-printed carbon electrode array. The potentiostat performs simultaneous acquisition of bidirectional reduction-oxidation currents proportional to neurotr...

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Bibliographic Details
Published in:IEEE transactions on circuits and systems. I, Regular papers Vol. 53; no. 11; pp. 2371 - 2376
Main Authors: Genov, R., Stanacevic, M., Naware, M., Cauwenberghs, G., Thakor, N.V.
Format: Journal Article
Language:English
Published: New York IEEE 01.11.2006
The Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subjects:
Analog VLSI
Arrays
Bandwidth
BiCMOS integrated circuits
biomedical instrumentation
Circuits
current-mode circuits
Cutoff frequency
dopamine sensor arrays
Dynamic range
Electrode potentials
Electrodes
Gain control
Integrated circuits
log-domain signal processing
Monitoring
Neurotransmitters
potentiostat
Potentiostats
Proportional control
Very large scale integration
ISSN:1549-8328, 1558-0806
Online Access:Get full text
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Summary:We present the architecture and VLSI circuit implementation of a BiCMOS potentiostat bank for monitoring neurotransmitter concentration on a screen-printed carbon electrode array. The potentiostat performs simultaneous acquisition of bidirectional reduction-oxidation currents proportional to neurotransmitter concentration on 16 independent channels at controlled redox potentials. Programmable current gain control yields over 100-dB cross-scale dynamic range with 46-pA input-referred rms noise over 12-kHz bandwidth. The cutoff frequency of a second-order log-domain anti-aliasing filter ranges from 50 Hz to 400 kHz. Track-and-hold current integration is triggered at the sampling rate between dc and 200 kHz. A 2.25-mmtimes2.25-mm prototype was fabricated in a 1.2-mum VLSI technology and dissipates 12.5 mW. Chronoamperometry dopamine concentration measurements results are given. Other types of neurotransmitters can be selected by adjusting the redox potential on the electrodes and the surface properties of the sensor coating
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ISSN:1549-8328
1558-0806
DOI:10.1109/TCSI.2006.884425