Reduced susceptibility and resistance to bedaquiline in clinical M. tuberculosis isolates

•Elevated bedaquiline MIC is found in clinical M. tuberculosis isolates.•MIC change is driven by mutations in mmpR (rv0678) and atpE genes.•AtpE substitutions G25S, D28G, D28N, E61D, A63P, and A63V were observed in vivo.•Substitutions in codon 63 of AtpE were likely associated with a higher bedaquil...

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Veröffentlicht in:	The Journal of infection Jg. 80; H. 5; S. 527 - 535
Hauptverfasser:	Peretokina, Irina V., Krylova, Ludmila Yu, Antonova, Olga V., Kholina, Margarita S., Kulagina, Elena V., Nosova, Elena Yu, Safonova, Svetlana G., Borisov, Sergey E., Zimenkov, Danila V.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Elsevier Ltd 01.05.2020
Schlagworte:	Antitubercular Agents - pharmacology Antitubercular Agents - therapeutic use AtpE Bedaquiline Diarylquinolines - pharmacology Drug resistance Humans Microbial Sensitivity Tests Mmpr(Rv0678) Mutation Mycobacterium tuberculosis - genetics Tuberculosis Tuberculosis - drug therapy Tuberculosis, Multidrug-Resistant - drug therapy Mmpr(Rv0678) Tuberculosis Drug resistance Bedaquiline AtpE
ISSN:	0163-4453, 1532-2742, 1532-2742
Online-Zugang:	Volltext
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