Reduced susceptibility and resistance to bedaquiline in clinical M. tuberculosis isolates

•Elevated bedaquiline MIC is found in clinical M. tuberculosis isolates.•MIC change is driven by mutations in mmpR (rv0678) and atpE genes.•AtpE substitutions G25S, D28G, D28N, E61D, A63P, and A63V were observed in vivo.•Substitutions in codon 63 of AtpE were likely associated with a higher bedaquil...

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Bibliographic Details
Published in:	The Journal of infection Vol. 80; no. 5; pp. 527 - 535
Main Authors:	Peretokina, Irina V., Krylova, Ludmila Yu, Antonova, Olga V., Kholina, Margarita S., Kulagina, Elena V., Nosova, Elena Yu, Safonova, Svetlana G., Borisov, Sergey E., Zimenkov, Danila V.
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01.05.2020
Subjects:	Antitubercular Agents - pharmacology Antitubercular Agents - therapeutic use AtpE Bedaquiline Diarylquinolines - pharmacology Drug resistance Humans Microbial Sensitivity Tests Mmpr(Rv0678) Mutation Mycobacterium tuberculosis - genetics Tuberculosis Tuberculosis - drug therapy Tuberculosis, Multidrug-Resistant - drug therapy Mmpr(Rv0678) Tuberculosis Drug resistance Bedaquiline AtpE
ISSN:	0163-4453, 1532-2742, 1532-2742
Online Access:	Get full text
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