Genetics of Depressive Disorders: Candidate Genes and Genome-Wide Association Studies

The search for molecular genetic markers of depression has been going on for more than two decades, and it began with molecular studies of the genes of the neurotransmitter systems, primarily serotonin and dopamine. However, for most genes, the results of such studies remain contradictory. In the la...

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Veröffentlicht in:Russian journal of genetics Jg. 56; H. 8; S. 903 - 915
Hauptverfasser: Rafikova, E. I., Ryskov, A. P., Vasilyev, V. A.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Moscow Pleiades Publishing 01.08.2020
Schlagworte:
Animal Genetics and Genomics
Biomedical and Life Sciences
Biomedicine
dopamine
Human Genetics
Microbial Genetics and Genomics
neurotransmitters
Reviews and Theoretical Articles
serotonin
GWAS
depression
dopaminergic system
SNP
serotonergic system
genome-wide association study
ISSN:1022-7954, 1608-3369
Online-Zugang:Volltext
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Abstract The search for molecular genetic markers of depression has been going on for more than two decades, and it began with molecular studies of the genes of the neurotransmitter systems, primarily serotonin and dopamine. However, for most genes, the results of such studies remain contradictory. In the last decade, a new approach has been used to study the genetics of multifactorial diseases—a genome-wide search for associations. This method made it possible to supplement the list of potential genetic risk factors for depression with new genes that require additional research. The review describes two different approaches to the study of the genetics of depression, as well as current problems and recent advances in this field.
AbstractList The search for molecular genetic markers of depression has been going on for more than two decades, and it began with molecular studies of the genes of the neurotransmitter systems, primarily serotonin and dopamine. However, for most genes, the results of such studies remain contradictory. In the last decade, a new approach has been used to study the genetics of multifactorial diseases—a genome-wide search for associations. This method made it possible to supplement the list of potential genetic risk factors for depression with new genes that require additional research. The review describes two different approaches to the study of the genetics of depression, as well as current problems and recent advances in this field.
Author Vasilyev, V. A.
Ryskov, A. P.
Rafikova, E. I.
Author_xml – sequence: 1
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  surname: Rafikova
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  givenname: A. P.
  surname: Ryskov
  fullname: Ryskov, A. P.
  organization: Institute of Gene Biology, Russian Academy of Sciences
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  givenname: V. A.
  surname: Vasilyev
  fullname: Vasilyev, V. A.
  organization: Institute of Gene Biology, Russian Academy of Sciences
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Keywords GWAS
depression
dopaminergic system
SNP
serotonergic system
genome-wide association study
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SubjectTerms Animal Genetics and Genomics
Biomedical and Life Sciences
Biomedicine
dopamine
Human Genetics
Microbial Genetics and Genomics
neurotransmitters
Reviews and Theoretical Articles
serotonin
Title Genetics of Depressive Disorders: Candidate Genes and Genome-Wide Association Studies
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