Common and Specific Genetic Risk Factors for Three Disorders with Depressive Symptoms

Searching for genetic causes of depressive and anxiety disorders has been going on for about three decades. However, the accumulated experimental data do not allow us to come to a final conclusion about the influence of certain genes on the risk of the disease and the severity of its course. Most st...

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Vydáno v:	Russian journal of genetics Ročník 58; číslo 1; s. 65 - 72
Hlavní autoři:	Rafikova, E. I., Shibalev, D. V., Shadrina, M. I., Slominsky, P. A., Guekht, A. B., Ryskov, A. P., Vasilyev, V. A.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Moscow Pleiades Publishing 01.02.2022
Témata:	alleles Animal Genetics and Genomics anxiety Biomedical and Life Sciences Biomedicine homozygosity Human Genetics loci mental depression Microbial Genetics and Genomics personality risk factors polymorphic loci genetic association anxiety disorders depressive disorders
ISSN:	1022-7954, 1608-3369
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Abstract	Searching for genetic causes of depressive and anxiety disorders has been going on for about three decades. However, the accumulated experimental data do not allow us to come to a final conclusion about the influence of certain genes on the risk of the disease and the severity of its course. Most studies of candidate genes were carried out using samples of patients with different nosological forms of depression. The aim of our work was to check whether the previously found associations are common for all depressive spectrum disorders or there are loci that specifically affect the risk of developing a certain disease. The study involved patients with disorders characterized by severe depressive symptoms ( n = 357). Patients were divided into three samples according to the diagnosis: depressive episode (DE), recurrent depression (RD), and mixed anxiety and depressive disorder (MADD). The polymorphic locus 40 bp VNTR of gene SLC6A3 was associated with all studied disorders; the LL genotype was less common in patients and was associated with a low risk of disease. The polymorphism 120 bp VNTR in gene DRD4 was associated with RD and MADD. The rs6311 locus of gene HTR2A was associated with DE and MADD. A specific genetic risk factor for RD in the studied samples was the rs53576 polymorphism of gene OXTR . The genotype homozygous for the minor allele (AA) was associated with a low risk of RD. None of the studied polymorphic loci influenced the severity of depression symptoms. The loci rs6311 of gene HTR2A and 120 bp VNTR of gene DRD4 were associated with symptoms of situational and personality anxiety. The severity of situational anxiety symptoms was also influenced by the loci rs53576 of gene OXTR and 16–17 bp VNTR of gene SLC6A4 .
AbstractList	Searching for genetic causes of depressive and anxiety disorders has been going on for about three decades. However, the accumulated experimental data do not allow us to come to a final conclusion about the influence of certain genes on the risk of the disease and the severity of its course. Most studies of candidate genes were carried out using samples of patients with different nosological forms of depression. The aim of our work was to check whether the previously found associations are common for all depressive spectrum disorders or there are loci that specifically affect the risk of developing a certain disease. The study involved patients with disorders characterized by severe depressive symptoms (n = 357). Patients were divided into three samples according to the diagnosis: depressive episode (DE), recurrent depression (RD), and mixed anxiety and depressive disorder (MADD). The polymorphic locus 40 bp VNTR of gene SLC6A3 was associated with all studied disorders; the LL genotype was less common in patients and was associated with a low risk of disease. The polymorphism 120 bp VNTR in gene DRD4 was associated with RD and MADD. The rs6311 locus of gene HTR2A was associated with DE and MADD. A specific genetic risk factor for RD in the studied samples was the rs53576 polymorphism of gene OXTR. The genotype homozygous for the minor allele (AA) was associated with a low risk of RD. None of the studied polymorphic loci influenced the severity of depression symptoms. The loci rs6311 of gene HTR2A and 120 bp VNTR of gene DRD4 were associated with symptoms of situational and personality anxiety. The severity of situational anxiety symptoms was also influenced by the loci rs53576 of gene OXTR and 16–17 bp VNTR of gene SLC6A4. Searching for genetic causes of depressive and anxiety disorders has been going on for about three decades. However, the accumulated experimental data do not allow us to come to a final conclusion about the influence of certain genes on the risk of the disease and the severity of its course. Most studies of candidate genes were carried out using samples of patients with different nosological forms of depression. The aim of our work was to check whether the previously found associations are common for all depressive spectrum disorders or there are loci that specifically affect the risk of developing a certain disease. The study involved patients with disorders characterized by severe depressive symptoms ( n = 357). Patients were divided into three samples according to the diagnosis: depressive episode (DE), recurrent depression (RD), and mixed anxiety and depressive disorder (MADD). The polymorphic locus 40 bp VNTR of gene SLC6A3 was associated with all studied disorders; the LL genotype was less common in patients and was associated with a low risk of disease. The polymorphism 120 bp VNTR in gene DRD4 was associated with RD and MADD. The rs6311 locus of gene HTR2A was associated with DE and MADD. A specific genetic risk factor for RD in the studied samples was the rs53576 polymorphism of gene OXTR . The genotype homozygous for the minor allele (AA) was associated with a low risk of RD. None of the studied polymorphic loci influenced the severity of depression symptoms. The loci rs6311 of gene HTR2A and 120 bp VNTR of gene DRD4 were associated with symptoms of situational and personality anxiety. The severity of situational anxiety symptoms was also influenced by the loci rs53576 of gene OXTR and 16–17 bp VNTR of gene SLC6A4 .
Author	Vasilyev, V. A. Slominsky, P. A. Shadrina, M. I. Rafikova, E. I. Shibalev, D. V. Guekht, A. B. Ryskov, A. P.
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Copyright	Pleiades Publishing, Inc. 2022. ISSN 1022-7954, Russian Journal of Genetics, 2022, Vol. 58, No. 1, pp. 65–72. © Pleiades Publishing, Inc., 2022. Russian Text © The Author(s), 2022, published in Genetika, 2022, Vol. 58, No. 1, pp. 76–85.
Copyright_xml	– notice: Pleiades Publishing, Inc. 2022. ISSN 1022-7954, Russian Journal of Genetics, 2022, Vol. 58, No. 1, pp. 65–72. © Pleiades Publishing, Inc., 2022. Russian Text © The Author(s), 2022, published in Genetika, 2022, Vol. 58, No. 1, pp. 76–85.
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References	DuanJ.SandersA.R.MolenJ.E.Polymorphisms in the 5'-untranslated region of the human serotonin receptor 1B (HTR1B) gene affect gene expressionMol. Psychiatry200389019101:CAS:528:DC%2BD3sXosFajt7k%3D10.1038/sj.mp.400140314593427 ParsonsM.J.D’SouzaU.M.ArranzetM.J.The –1438A/G polymorphism in the 5-hydroxytryptamine type 2A receptor gene affects promoter activityBiol. Psychiatry2004564064101:CAS:528:DC%2BD2cXnsFSmu7c%3D10.1016/j.biopsych.2004.06.02015364038 NaK.S.D’SouzaU.M.ArranzM.J.Interaction effects of oxytocin receptor gene polymorphism and depression on hippocampal volumePsychiatry Res. Neuroimaging2018282182310.1016/j.pscychresns.2018.10.00430384146 FehretdinovaD.I.SukhodolskayaE.M.ShibalevD.V.Polymorphism of the two genes encoding catecholamine degradation enzymes (COMT and MAOA) in the Hadza and Datoga African ethnic populationsMol. Genet., Microbiol. Virol.20183319520010.3103/S0891416818030035 HeilsA.MossnerR.LeschK.P.The human serotonin transporter gene polymorphism—basic research and clinical implicationsJ. Neural. Transm.1997104100510141:CAS:528:DyaK1cXhsVCks7g%3D10.1007/BF01273314 Sukhodol’skayaE.M.Vasil’evV.A.ShibalevD.V.3′-UTR polymorphism of dopamine transporter gene in Hadza and Datoga malesMol. Biol.2014482542571:CAS:528:DC%2BC2cXntFGgtro%3D10.1134/S0026893314020174 RafikovaE.I.RyskovA.P.VasilyevV.A.Genetics of depressive disorders: candidate genes and genome-wide association studiesRuss. J. Genet.2020569039151:CAS:528:DC%2BB3cXhslSltr%2FE10.1134/S1022795420080116 Bielinski, M., Jaracz, M., Lesiewska, N., et al., Association between COMT Val158Met and DAT1 polymorphisms and depressive symptoms in the obese population, Neuropsychiatr. Dis. Treat., 2017, no. 13, pp. 2221—2229. https://doi.org/10.2147/NDT.S138565 D’SouzaU.M.RussaC.TahiretE.Functional effects of a tandem duplication polymorphism in the 5'flanking region of the DRD4 geneBiol. Psychiatry2004566916971:CAS:528:DC%2BD2cXptFOmt7o%3D10.1016/j.biopsych.2004.08.00815522254 SchootsO.Van TolH.H.The human dopamine D4 receptor repeat sequences modulate expressionPharmacogenomics J.200333433481:CAS:528:DC%2BD3sXps1yiur4%3D10.1038/sj.tpj.650020814581929 Lai, J.H., Zhuab, Y.S., Huoet, Z.H., et al., Association study of polymorphisms in the promoter region of DRD4 with schizophrenia, depression, and heroin addiction, Brain Res., 2010, no. 1359, pp. 227—232. https://doi.org/10.1016/j.brainres.2010.08.064 ZhaoX.SunL.SunY.H.Association of HTR2A T102C and A-1438G polymorphisms with susceptibility to major depressive disorder: a meta-analysisNeurol. Sci.2014351857186610.1007/s10072-014-1970-725270656 LenzeE.J.ShardellM.FerrellR.E.Association of serotonin-1A and 2A receptor promoter polymorphisms with depressive symptoms and functional recovery in elderly persons after hip fractureJ. Affective Disord.200811161661:CAS:528:DC%2BD1cXhtFylsrrL10.1016/j.jad.2008.02.005 Inoue-MurayamaM.AdachiaS.MishimaN.Variation of variable number of tandem repeat sequences in the 3'-untranslated region of primate dopamine transporter genes that affects reporter gene expressionNeurosci. Lett.20023342062101:CAS:528:DC%2BD38XovFGls78%3D10.1016/S0304-3940(02)01125-412453630 NobleE.P.BlumK.RitchieT.Allelic association of the D2 dopamine receptor gene with receptor-binding characteristics in alcoholismArch. Gen. Psychiatry1991486486541:STN:280:DyaK3M3pvVyntg%3D%3D10.1001/archpsyc.1991.018103100660122069496 RafikovaE.I.ShibalevD.V.ShadrinaM.I.SlominskyP.A.GuekhtA.B.RyskovA.P.VasilyevV.A.Influence of polymorphic gene variants of the dopaminergic system on the risk of disorders with depressive symptomsRuss. J. Genet.2021579429481:CAS:528:DC%2BB3MXhvFWqurvI10.1134/S1022795421070115 LemondeS.TureckiG.BakishD.Impaired repression at a 5-hydroxytryptamine 1A receptor gene polymorphism associated with major depression and suicideJ. Neurosci.200323878887991:CAS:528:DC%2BD3sXnvVWlsr8%3D10.1523/JNEUROSCI.23-25-08788.2003145079796740417 HuX.Z.LipskyR.H.ZhuG.Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorderAm. J. Hum. Genet.2006788158261:CAS:528:DC%2BD28Xkt1Ggsro%3D10.1086/503850166424371474042 MolinaE.CervillaJ.RiveraM.Polymorphic variation at the serotonin 1-A receptor gene is associated with comorbid depression and generalized anxietyPsychiatr. Genet.20112119520110.1097/YPG.0b013e3283457a4821512427 CostaB.PiniS.GabelloniP.Oxytocin receptor polymorphisms and adult attachment style in patients with depressionPsychoneuroendocrinology200934150615141:CAS:528:DC%2BD1MXht1Ogtb3L10.1016/j.psyneuen.2009.05.00619515497 SukhodolskayaE.M.FehretdinovaD.I.ShibalevD.V.Polymorphisms of dopamine receptor genes DRD2 and DRD4 in African populations of Hadza and Datoga differing in the level of culturally permitted aggressionAnn. Hum. Genet.2018824074141:CAS:528:DC%2BC1cXhvFeqsbrE10.1111/ahg.1226330009502 CzesakM.LemondeS.PetersonE.A.Cell-specific repressor or enhancer activities of Deaf-1 at a serotonin 1A receptor gene polymorphismJ. Neurosci.200626186418711:CAS:528:DC%2BD28XhslCht7g%3D10.1523/JNEUROSCI.2643-05.2006164675356793620 LachmanH.M.PapolosD.F.SaitoT.Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disordersPharmacogenetics199662432501:CAS:528:DyaK28XksFemsLw%3D10.1097/00008571-199606000-000078807664 Van Ness, S.H., Owens, M.J. and Kilts, C.D., The variable number of tandem repeats element in DAT1 regulates in vitro dopamine transporter density, BMC Genet., 2005, no. 6, p. 55. https://doi.org/10.1186/1471-2156-6-55 MacKenzieA.QuinnJ.A serotonin transporter gene intron 2 polymorphic region, correlated with affective disorders, has allele-dependent differential enhancer-like properties in the mouse embryoProc. Natl. Acad. Sci. U.S.A.19999615251152551:CAS:528:DC%2BD3cXhtFeisw%3D%3D10.1073/pnas.96.26.152511061137124806 1555_CR14 U.M. D’Souza (1555_CR4) 2004; 56 M.J. Parsons (1555_CR13) 2004; 56 1555_CR15 M. Inoue-Murayama (1555_CR2) 2002; 334 E. Molina (1555_CR18) 2011; 21 X. Zhao (1555_CR16) 2014; 35 E.I. Rafikova (1555_CR19) 2020; 56 H.M. Lachman (1555_CR6) 1996; 6 A. MacKenzie (1555_CR9) 1999; 96 E.M. Sukhodolskaya (1555_CR23) 2018; 82 O. Schoots (1555_CR3) 2003; 3 E.J. Lenze (1555_CR17) 2008; 111 A. Heils (1555_CR7) 1997; 104 X.Z. Hu (1555_CR8) 2006; 78 K.S. Na (1555_CR20) 2018; 282 1555_CR1 S. Lemonde (1555_CR10) 2003; 23 E.I. Rafikova (1555_CR22) 2021; 57 D.I. Fehretdinova (1555_CR24) 2018; 33 J. Duan (1555_CR12) 2003; 8 E.P. Noble (1555_CR5) 1991; 48 E.M. Sukhodol’skaya (1555_CR25) 2014; 48 B. Costa (1555_CR21) 2009; 34 M. Czesak (1555_CR11) 2006; 26
References_xml	– reference: LachmanH.M.PapolosD.F.SaitoT.Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disordersPharmacogenetics199662432501:CAS:528:DyaK28XksFemsLw%3D10.1097/00008571-199606000-000078807664 – reference: Sukhodol’skayaE.M.Vasil’evV.A.ShibalevD.V.3′-UTR polymorphism of dopamine transporter gene in Hadza and Datoga malesMol. Biol.2014482542571:CAS:528:DC%2BC2cXntFGgtro%3D10.1134/S0026893314020174 – reference: HeilsA.MossnerR.LeschK.P.The human serotonin transporter gene polymorphism—basic research and clinical implicationsJ. Neural. Transm.1997104100510141:CAS:528:DyaK1cXhsVCks7g%3D10.1007/BF01273314 – reference: FehretdinovaD.I.SukhodolskayaE.M.ShibalevD.V.Polymorphism of the two genes encoding catecholamine degradation enzymes (COMT and MAOA) in the Hadza and Datoga African ethnic populationsMol. Genet., Microbiol. Virol.20183319520010.3103/S0891416818030035 – reference: MolinaE.CervillaJ.RiveraM.Polymorphic variation at the serotonin 1-A receptor gene is associated with comorbid depression and generalized anxietyPsychiatr. Genet.20112119520110.1097/YPG.0b013e3283457a4821512427 – reference: MacKenzieA.QuinnJ.A serotonin transporter gene intron 2 polymorphic region, correlated with affective disorders, has allele-dependent differential enhancer-like properties in the mouse embryoProc. Natl. Acad. Sci. U.S.A.19999615251152551:CAS:528:DC%2BD3cXhtFeisw%3D%3D10.1073/pnas.96.26.152511061137124806 – reference: ParsonsM.J.D’SouzaU.M.ArranzetM.J.The –1438A/G polymorphism in the 5-hydroxytryptamine type 2A receptor gene affects promoter activityBiol. Psychiatry2004564064101:CAS:528:DC%2BD2cXnsFSmu7c%3D10.1016/j.biopsych.2004.06.02015364038 – reference: ZhaoX.SunL.SunY.H.Association of HTR2A T102C and A-1438G polymorphisms with susceptibility to major depressive disorder: a meta-analysisNeurol. Sci.2014351857186610.1007/s10072-014-1970-725270656 – reference: NobleE.P.BlumK.RitchieT.Allelic association of the D2 dopamine receptor gene with receptor-binding characteristics in alcoholismArch. Gen. Psychiatry1991486486541:STN:280:DyaK3M3pvVyntg%3D%3D10.1001/archpsyc.1991.018103100660122069496 – reference: Inoue-MurayamaM.AdachiaS.MishimaN.Variation of variable number of tandem repeat sequences in the 3'-untranslated region of primate dopamine transporter genes that affects reporter gene expressionNeurosci. Lett.20023342062101:CAS:528:DC%2BD38XovFGls78%3D10.1016/S0304-3940(02)01125-412453630 – reference: LemondeS.TureckiG.BakishD.Impaired repression at a 5-hydroxytryptamine 1A receptor gene polymorphism associated with major depression and suicideJ. Neurosci.200323878887991:CAS:528:DC%2BD3sXnvVWlsr8%3D10.1523/JNEUROSCI.23-25-08788.2003145079796740417 – reference: RafikovaE.I.ShibalevD.V.ShadrinaM.I.SlominskyP.A.GuekhtA.B.RyskovA.P.VasilyevV.A.Influence of polymorphic gene variants of the dopaminergic system on the risk of disorders with depressive symptomsRuss. J. Genet.2021579429481:CAS:528:DC%2BB3MXhvFWqurvI10.1134/S1022795421070115 – reference: Lai, J.H., Zhuab, Y.S., Huoet, Z.H., et al., Association study of polymorphisms in the promoter region of DRD4 with schizophrenia, depression, and heroin addiction, Brain Res., 2010, no. 1359, pp. 227—232. https://doi.org/10.1016/j.brainres.2010.08.064 – reference: CzesakM.LemondeS.PetersonE.A.Cell-specific repressor or enhancer activities of Deaf-1 at a serotonin 1A receptor gene polymorphismJ. Neurosci.200626186418711:CAS:528:DC%2BD28XhslCht7g%3D10.1523/JNEUROSCI.2643-05.2006164675356793620 – reference: Bielinski, M., Jaracz, M., Lesiewska, N., et al., Association between COMT Val158Met and DAT1 polymorphisms and depressive symptoms in the obese population, Neuropsychiatr. Dis. Treat., 2017, no. 13, pp. 2221—2229. https://doi.org/10.2147/NDT.S138565 – reference: SukhodolskayaE.M.FehretdinovaD.I.ShibalevD.V.Polymorphisms of dopamine receptor genes DRD2 and DRD4 in African populations of Hadza and Datoga differing in the level of culturally permitted aggressionAnn. Hum. Genet.2018824074141:CAS:528:DC%2BC1cXhvFeqsbrE10.1111/ahg.1226330009502 – reference: D’SouzaU.M.RussaC.TahiretE.Functional effects of a tandem duplication polymorphism in the 5'flanking region of the DRD4 geneBiol. Psychiatry2004566916971:CAS:528:DC%2BD2cXptFOmt7o%3D10.1016/j.biopsych.2004.08.00815522254 – reference: HuX.Z.LipskyR.H.ZhuG.Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorderAm. J. Hum. Genet.2006788158261:CAS:528:DC%2BD28Xkt1Ggsro%3D10.1086/503850166424371474042 – reference: LenzeE.J.ShardellM.FerrellR.E.Association of serotonin-1A and 2A receptor promoter polymorphisms with depressive symptoms and functional recovery in elderly persons after hip fractureJ. Affective Disord.200811161661:CAS:528:DC%2BD1cXhtFylsrrL10.1016/j.jad.2008.02.005 – reference: RafikovaE.I.RyskovA.P.VasilyevV.A.Genetics of depressive disorders: candidate genes and genome-wide association studiesRuss. J. Genet.2020569039151:CAS:528:DC%2BB3cXhslSltr%2FE10.1134/S1022795420080116 – reference: SchootsO.Van TolH.H.The human dopamine D4 receptor repeat sequences modulate expressionPharmacogenomics J.200333433481:CAS:528:DC%2BD3sXps1yiur4%3D10.1038/sj.tpj.650020814581929 – reference: DuanJ.SandersA.R.MolenJ.E.Polymorphisms in the 5'-untranslated region of the human serotonin receptor 1B (HTR1B) gene affect gene expressionMol. Psychiatry200389019101:CAS:528:DC%2BD3sXosFajt7k%3D10.1038/sj.mp.400140314593427 – reference: Van Ness, S.H., Owens, M.J. and Kilts, C.D., The variable number of tandem repeats element in DAT1 regulates in vitro dopamine transporter density, BMC Genet., 2005, no. 6, p. 55. https://doi.org/10.1186/1471-2156-6-55 – reference: NaK.S.D’SouzaU.M.ArranzM.J.Interaction effects of oxytocin receptor gene polymorphism and depression on hippocampal volumePsychiatry Res. Neuroimaging2018282182310.1016/j.pscychresns.2018.10.00430384146 – reference: CostaB.PiniS.GabelloniP.Oxytocin receptor polymorphisms and adult attachment style in patients with depressionPsychoneuroendocrinology200934150615141:CAS:528:DC%2BD1MXht1Ogtb3L10.1016/j.psyneuen.2009.05.00619515497 – volume: 35 start-page: 1857 year: 2014 ident: 1555_CR16 publication-title: Neurol. Sci. doi: 10.1007/s10072-014-1970-7 – ident: 1555_CR14 doi: 10.2147/NDT.S138565 – volume: 111 start-page: 61 year: 2008 ident: 1555_CR17 publication-title: J. Affective Disord. doi: 10.1016/j.jad.2008.02.005 – volume: 57 start-page: 942 year: 2021 ident: 1555_CR22 publication-title: Russ. J. Genet. doi: 10.1134/S1022795421070115 – volume: 21 start-page: 195 year: 2011 ident: 1555_CR18 publication-title: Psychiatr. Genet. doi: 10.1097/YPG.0b013e3283457a48 – volume: 8 start-page: 901 year: 2003 ident: 1555_CR12 publication-title: Mol. Psychiatry doi: 10.1038/sj.mp.4001403 – ident: 1555_CR15 doi: 10.1016/j.brainres.2010.08.064 – volume: 33 start-page: 195 year: 2018 ident: 1555_CR24 publication-title: Mol. Genet., Microbiol. Virol. doi: 10.3103/S0891416818030035 – volume: 56 start-page: 903 year: 2020 ident: 1555_CR19 publication-title: Russ. J. Genet. doi: 10.1134/S1022795420080116 – volume: 334 start-page: 206 year: 2002 ident: 1555_CR2 publication-title: Neurosci. Lett. doi: 10.1016/S0304-3940(02)01125-4 – volume: 56 start-page: 406 year: 2004 ident: 1555_CR13 publication-title: Biol. Psychiatry doi: 10.1016/j.biopsych.2004.06.020 – volume: 82 start-page: 407 year: 2018 ident: 1555_CR23 publication-title: Ann. Hum. Genet. doi: 10.1111/ahg.12263 – ident: 1555_CR1 doi: 10.1186/1471-2156-6-55 – volume: 104 start-page: 1005 year: 1997 ident: 1555_CR7 publication-title: J. Neural. Transm. doi: 10.1007/BF01273314 – volume: 282 start-page: 18 year: 2018 ident: 1555_CR20 publication-title: Psychiatry Res. Neuroimaging doi: 10.1016/j.pscychresns.2018.10.004 – volume: 56 start-page: 691 year: 2004 ident: 1555_CR4 publication-title: Biol. Psychiatry doi: 10.1016/j.biopsych.2004.08.008 – volume: 96 start-page: 15251 year: 1999 ident: 1555_CR9 publication-title: Proc. Natl. Acad. Sci. U.S.A. doi: 10.1073/pnas.96.26.15251 – volume: 3 start-page: 343 year: 2003 ident: 1555_CR3 publication-title: Pharmacogenomics J. doi: 10.1038/sj.tpj.6500208 – volume: 6 start-page: 243 year: 1996 ident: 1555_CR6 publication-title: Pharmacogenetics doi: 10.1097/00008571-199606000-00007 – volume: 78 start-page: 815 year: 2006 ident: 1555_CR8 publication-title: Am. J. Hum. Genet. doi: 10.1086/503850 – volume: 23 start-page: 8788 year: 2003 ident: 1555_CR10 publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.23-25-08788.2003 – volume: 48 start-page: 254 year: 2014 ident: 1555_CR25 publication-title: Mol. Biol. doi: 10.1134/S0026893314020174 – volume: 48 start-page: 648 year: 1991 ident: 1555_CR5 publication-title: Arch. Gen. Psychiatry doi: 10.1001/archpsyc.1991.01810310066012 – volume: 34 start-page: 1506 year: 2009 ident: 1555_CR21 publication-title: Psychoneuroendocrinology doi: 10.1016/j.psyneuen.2009.05.006 – volume: 26 start-page: 1864 year: 2006 ident: 1555_CR11 publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.2643-05.2006
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Snippet	Searching for genetic causes of depressive and anxiety disorders has been going on for about three decades. However, the accumulated experimental data do not...
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Title	Common and Specific Genetic Risk Factors for Three Disorders with Depressive Symptoms
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