Effects of frusemide on the urinary excretion of dopamine and 5-hydroxytryptamine in normal man

The effects of frusemide on the urinary excretion of dopamine and 5-hydroxytryptamine (5-HT) were investigated in eight healthy male subjects in a randomized, placebo-controlled, cross-over study. Frusemide produced the expected rise in urinary dopamine excretion but it did not affect 5-HT excretion...

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Vydáno v:British journal of clinical pharmacology Ročník 42; číslo 4; s. 522
Hlavní autoři: Li Kam Wa, T C, Freestone, S, McCrindle, J L, Samson, R R, Johnston, N R, Lee, M R
Médium: Journal Article
Jazyk:angličtina
Vydáno: England 01.10.1996
Témata:
Adult
Diuretics - urine
Dopamine - urine
Furosemide - pharmacology
Humans
Male
Placebos
Serotonin - urine
ISSN:0306-5251
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Shrnutí:The effects of frusemide on the urinary excretion of dopamine and 5-hydroxytryptamine (5-HT) were investigated in eight healthy male subjects in a randomized, placebo-controlled, cross-over study. Frusemide produced the expected rise in urinary dopamine excretion but it did not affect 5-HT excretion when compared with placebo. The lack of an effect on 5-HT excretion in man contrasts with studies in the rat which have reported a marked increase in 5-HT excretion after administration of this loop diuretic.
Bibliografie:ObjectType-Article-2
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ISSN:0306-5251
DOI:10.1046/j.1365-2125.1996.46120.x