Interventional 4-D C-Arm CT Perfusion Imaging Using Interleaved Scanning and Partial Reconstruction Interpolation

Tissue perfusion measurement during catheter-guided stroke treatment in the interventional suite is currently not possible. In this work, we present a novel approach that uses a C-arm angiography system capable of computed tomography (CT)-like imaging (C-arm CT) for this purpose. With C-arm CT one r...

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Veröffentlicht in:IEEE transactions on medical imaging Jg. 31; H. 4; S. 892 - 906
Hauptverfasser: Fieselmann, A., Ganguly, A., Deuerling-Zheng, Y., Zellerhoff, M., Rohkohl, C., Boese, J., Hornegger, J., Fahrig, R.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States IEEE 01.04.2012
Schlagworte:
Angiography - methods
Animals
Brain - blood supply
Brain - diagnostic imaging
C-arm computed tomography (CT)
Cerebrovascular Circulation - physiology
Computed tomography
Computer Simulation
dynamic reconstruction
Image reconstruction
Interpolation
Legged locomotion
Models, Biological
perfusion imaging
Perfusion Imaging - methods
Phantoms, Imaging
Protocols
Radiographic Image Enhancement - methods
Reconstruction algorithms
Reproducibility of Results
stroke treatment
Swine
Tomography, X-Ray Computed - methods
ISSN:0278-0062, 1558-254X, 1558-254X
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Zusammenfassung:Tissue perfusion measurement during catheter-guided stroke treatment in the interventional suite is currently not possible. In this work, we present a novel approach that uses a C-arm angiography system capable of computed tomography (CT)-like imaging (C-arm CT) for this purpose. With C-arm CT one reconstructed volume can be obtained every 4-6 s which makes it challenging to measure the flow of an injected contrast bolus. We have developed an interleaved scanning (IS) protocol that uses several scan sequences to increase temporal sampling. Using a dedicated 4-D reconstruction approach based on partial reconstruction interpolation (PRI) we can optimally process our data. We evaluated our combined approach (IS-PRI) with simulations and a study in five healthy pigs. In our simulations, the cerebral blood flow values (unit: ml/100 g/min) were 60 (healthy tissue) and 20 (pathological tissue). For one scan sequence the values were estimated with standard deviations of 14.3 and 2.9, respectively. For two interleaved sequences the standard deviations decreased to 3.6 and 1.5, respectively. We used perfusion CT to validate the in vivo results. With two interleaved sequences we achieved promising correlations ranging from r =0.63 to r =0.94. The results suggest that C-arm CT tissue perfusion imaging is feasible with two interleaved scan sequences.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:0278-0062
1558-254X
1558-254X
DOI:10.1109/TMI.2011.2181531