Overcoming muscle stem cell aging
Reduced muscle strength and mass is one of the hallmarks of physiological aging in humans and can result in severe impairment of the quality of life. In part this is caused by a functional loss of the highly specialized muscle stem cells (MuSCs), which in healthy conditions provide maintenance, grow...
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| Veröffentlicht in: | Current opinion in genetics & development Jg. 83; S. 102127 |
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| Hauptverfasser: | , |
| Format: | Journal Article |
| Sprache: | Englisch |
| Veröffentlicht: |
England
Elsevier Ltd
01.12.2023
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| Schlagworte: | |
| ISSN: | 0959-437X, 1879-0380, 1879-0380 |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | Reduced muscle strength and mass is one of the hallmarks of physiological aging in humans and can result in severe impairment of the quality of life. In part this is caused by a functional loss of the highly specialized muscle stem cells (MuSCs), which in healthy conditions provide maintenance, growth, and regeneration. Recent progress in understanding of the stem cell niche and results from single cell technologies reveal exciting insights at unprecedented detail into MuSCs and muscle biology during aging. Here, we review this field and discuss the implications of current findings with a focus on cellular reprogramming approaches as a novel therapeutic avenue for age-related muscle decline.
•Muscle stem cell function loss contributes to reduced strength in old age.•Single cell technologies reveal exciting details of muscle biology during aging.•Muscle Cellular Reprogramming is an innovative, promising therapeutic approach. |
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| Bibliographie: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 |
| ISSN: | 0959-437X 1879-0380 1879-0380 |
| DOI: | 10.1016/j.gde.2023.102127 |