A mixed integer programming approach to minibeam aperture optimization for multi‐collimator proton minibeam radiotherapy

Background Multi‐collimator proton minibeam radiation therapy (MC‐pMBRT) has recently emerged as a versatile technique for dose shaping, enabling the formation of peak‐valley dose patterns in organs‐at‐risk (OAR) while maintaining a uniform dose distribution in tumor targets. MC‐pMBRT leverages a se...

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Bibliographic Details
Published in:	Medical physics (Lancaster) Vol. 52; no. 11; pp. e70129 - n/a
Main Authors:	Shinde, Nimita, Zhang, Weijie, Lin, Yuting, Gao, Hao
Format:	Journal Article
Language:	English
Published:	United States 01.11.2025
Subjects:	Humans IMPT inverse optimization mixed‐integer programming Organs at Risk - radiation effects peak‐to‐valley dose ratio (PVDR) proton minibeam radiotherapy (pMBRT) Proton Therapy - instrumentation Proton Therapy - methods Radiotherapy Dosage Radiotherapy Planning, Computer-Assisted - methods mixed‐integer programming proton minibeam radiotherapy (pMBRT) IMPT peak‐to‐valley dose ratio (PVDR) inverse optimization
ISSN:	0094-2405, 2473-4209, 2473-4209
Online Access:	Get full text
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