Methoxyethyl Etomidate Hydrochloride (ET‐26): A Phase I Clinical Trial Assessing Drug–Drug Interactions in Healthy Subjects

Methoxyethyl etomidate hydrochloride (ET‐26) is a novel intravenous general anesthetic designed to address the clinical limitations of etomidate. This Phase I clinical trial assessed the pharmacokinetics, pharmacodynamics, drug–drug interaction (DDI) potential, and safety of ET‐26 in 68 healthy subj...

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Bibliographic Details
Published in:	Journal of clinical pharmacology Vol. 65; no. 11; pp. 1443 - 1450
Main Authors:	Yang, Fan, Ye, Pan‐Pan, Lv, Wen‐Shuo, Li, Li‐Ze, Zhao, Bao‐Zhong, van denAnker, John, Yang, Xin‐Mei, Song, Lin‐Lin, Yang, Xiao‐Ran, Zheng, Yi, Ke, Bo‐Wen, Zhao, Wei
Format:	Journal Article
Language:	English
Published:	England Wiley Subscription Services, Inc 01.11.2025
Subjects:	Adult Adverse events Anesthesia Anesthetics, Intravenous - administration & dosage Anesthetics, Intravenous - adverse effects Anesthetics, Intravenous - pharmacokinetics Anesthetics, Intravenous - pharmacology Area Under Curve Clinical trials Cross-Over Studies Cytochrome P-450 CYP2C19 - metabolism Drug interaction Drug Interactions drug–drug interaction Etomidate Etomidate - administration & dosage Etomidate - adverse effects Etomidate - analogs & derivatives Etomidate - pharmacokinetics Etomidate - pharmacology etomidate analogs Female Fluconazole Fluconazole - administration & dosage Fluconazole - pharmacokinetics Fluconazole - pharmacology Healthy Volunteers Humans intravenous anesthetic Male Midazolam Midazolam - pharmacokinetics Midazolam - pharmacology Middle Aged Myoclonus Omeprazole Omeprazole - pharmacokinetics Omeprazole - pharmacology Pharmacodynamics Pharmacokinetics Phase 1 clinical trial Rifampin Rifampin - pharmacokinetics Rifampin - pharmacology Young Adult pharmacokinetics Phase 1 clinical trial drug–drug interaction intravenous anesthetic etomidate analogs
ISSN:	0091-2700, 1552-4604, 1552-4604
Online Access:	Get full text
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