Aberrant Glycosylation in Pancreatic Ductal Adenocarcinoma 3D Organoids Is Mediated by KRAS Mutations

Aberrant glycosylation in tumor cells is a hallmark during carcinogenesis. KRAS gene mutations are the most well-known oncogenic abnormalities but their association with glycan alterations in pancreatic ductal adenocarcinoma (PDAC) is largely unknown. We employed patient-derived 3D organoids to cult...

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Veröffentlicht in:	Journal of oncology Jg. 2024; S. 1 - 12
Hauptverfasser:	Nakahashi, Hiromitsu, Oda, Tatsuya, Shimomura, Osamu, Akashi, Yoshimasa, Takahashi, Kazuhiro, Miyazaki, Yoshihiro, Furuta, Tomoaki, Kuroda, Yukihito, Louphrasitthiphol, Pakavarin, Mathis, Bryan J., Tateno, Hiroaki
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Egypt Hindawi 2024 John Wiley & Sons, Inc
Schlagworte:	Gene expression Glycosylation Lectins Morphology Mutation Pancreatic cancer Patients Proteins
ISSN:	1687-8450, 1687-8450, 1687-8469
Online-Zugang:	Volltext
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