Engineered MOFs and Enzymes for the Synthesis of Active Pharmaceutical Ingredients

The latest strategies in the design and synthesis of metal‐organic frameworks as heterogeneous catalysts in organic synthesis are compared with biocatalyzed transformations, as a step forward to a more convenient industrial production of pharmaceuticals. Relevant C−C and C−N bond forming reactions t...

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Bibliographic Details
Published in:ChemCatChem Vol. 11; no. 23; pp. 5671 - 5685
Main Author: Cirujano, Francisco G.
Format: Journal Article
Language:English
Published: Weinheim Wiley Subscription Services, Inc 05.12.2019
Subjects:
Chemical reactions
Chemical synthesis
Enzyme mimics
Enzymes
Heterogeneous catalysts
Metal-organic frameworks
MOFs
Organic synthesis
Pharmaceuticals
ISSN:1867-3880, 1867-3899
Online Access:Get full text
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Summary:The latest strategies in the design and synthesis of metal‐organic frameworks as heterogeneous catalysts in organic synthesis are compared with biocatalyzed transformations, as a step forward to a more convenient industrial production of pharmaceuticals. Relevant C−C and C−N bond forming reactions that are both chemo‐ and bio‐ catalyzed by synthetic MOFs and in vitro evolved and/or promiscuous enzymes with the aim of obtaining key bioactive scaffolds in a sustainable, competitive and cost‐efficient manner, are thoroughly discussed in this mini review. Catalysis for Pharma! Engineered enzymes and MOFs are compared as novel catalysts in the organic synthesis of interesting scaffolds in the context of cost‐efficient pharmaceutical processes.
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ISSN:1867-3880
1867-3899
DOI:10.1002/cctc.201900131