5-HTTLPR polymorphism, mood disorders and MDMA use in a 3-year follow-up study

A 3-year longitudinal prospective study was conducted to compare the incidence of substance use disorders (SUD) and non-substance use disorders (NSUD) among ecstasy users and two control groups: one of cannabis users and the other of non-drug users. The 5-HTTLPR polymorphism related to NSUD was also...

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Vydáno v:Addiction biology Ročník 15; číslo 1; s. 15 - 22
Hlavní autoři: Martín-Santos, Rocío, Torrens, Marta, Poudevida, Sandra, Langohr, Klaus, Cuyás, Elisabet, Pacifici, Roberta, Farré, Magí, Pichini, Simona, de la Torre, Rafael
Médium: Journal Article Publikace
Jazyk:angličtina
Vydáno: United States 01.01.2010
Témata:
Adolescent
Adult
Afecte (Psicologia)
Affective disorders
Alleles
Amphetamine-Related Disorders - epidemiology
Amphetamine-Related Disorders - genetics
Anàlisi multivariant
Cannabis
Comorbidity
Cross-Sectional Studies
Cànnabis
Drogues
Ecstasy (Drug)
Estadística aplicada
Estadística biosanitària
Estadística matemàtica
Female
Genetic Predisposition to Disease - genetics
Genotype
Humans
Incidence
Longitudinal Studies
Male
Marijuana Abuse - epidemiology
Marijuana Abuse - genetics
Matemàtiques i estadística
Mood Disorders - epidemiology
Mood Disorders - genetics
N-Methyl-3,4-methylenedioxyamphetamine
Polymorphism, Genetic - genetics
Prospective Studies
Serotonin Plasma Membrane Transport Proteins - genetics
Substance abuse
Young Adult
Àrees temàtiques de la UPC
Èxtasi
ISSN:1369-1600, 1355-6215, 1369-1600
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Popis
Shrnutí:A 3-year longitudinal prospective study was conducted to compare the incidence of substance use disorders (SUD) and non-substance use disorders (NSUD) among ecstasy users and two control groups: one of cannabis users and the other of non-drug users. The 5-HTTLPR polymorphism related to NSUD was also studied. A total of 94 subjects were included: 37 ecstasy users, 23 cannabis users and 34 non-drug users. SUD and NSUD disorders were diagnosed according to the fourth edition of the Diagnostic and Statistical Manual of Mental Health Disorders criteria using the Psychiatric Research Interview for Substance and Mental Disorders. Incidence Rates (IR) are presented. The 5-HTTLPR polymorphism was analyzed. Hardy-Weinberg equilibrium was studied. The results of the study showed that the highest IR of SUD was cannabis abuse/dependence in both the ecstasy (IR: 48.6/100 person-year) and cannabis (IR: 2.5/100 person-year) groups. There were no new cases of SUD in non-drug users at follow-up. The highest IR of NSUD was primary mood disorder in both the ecstasy (IR: 4.2/100 person-year) and in the non-drug (IR: 1.3/100 person-year) groups (P < 0.282). There were no new cases of NSUD in the cannabis group at follow-up. 5-HTTLPR polymorphism was associated with lifetime of primary mood disorders in ecstasy group (P = 0.018). Ecstasy use was associated with a higher rate of cannabis abuse/dependence disorders and mood disorders than cannabis use. In the ecstasy users, 5-HTTLPR polymorphism may result in a high vulnerability to primary mood disorders.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1369-1600
1355-6215
1369-1600
DOI:10.1111/j.1369-1600.2009.00180.x