Auditory P300 event-related potential and acoustic features of voice and speech in adolescents at risk for suicide: A pilot study

Suicide remains a leading cause of external mortality, posing a significant yet preventable challenge. This study explores potential associations between suicide risk and neurophysiological (Auditory P300 Event-Related Potential) and acoustic voice and speech parameters in adolescents. The study emp...

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Veröffentlicht in:Journal of neurolinguistics Jg. 77; S. 101296
Hauptverfasser: Figueroa Saavedra, Carla, Huenupán Quinán, Fernando, Guillén Cañas, Virginia, Méndez Bustos, Pablo, Alarcón Acuña, Enzo, Pérez, Hernán Emilio
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Elsevier Ltd 01.02.2026
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ISSN:0911-6044
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Abstract Suicide remains a leading cause of external mortality, posing a significant yet preventable challenge. This study explores potential associations between suicide risk and neurophysiological (Auditory P300 Event-Related Potential) and acoustic voice and speech parameters in adolescents. The study employed a cross-sectional design. Thirty secondary school students underwent auditory assessment, P300 measurement (PEATS Eclipse EP25), and acoustic analysis of voice and speech. Suicide risk was determined using the Okasha Suicidality Scale and the Beck Depression Inventory. Acoustic analysis was performed using Praat software for phonetic research, a Focusrite Scarlett interface, and a condenser microphone to assess fundamental frequency (F0), jitter, shimmer, and formants (F1, F2, F3). Data were analyzed using IBM SPSS Statistics version 26.0 and MATLAB R2022a (MathWorks Inc.) for signal processing and feature extraction, applying both descriptive and inferential statistical methods. Adolescents at risk for suicide exhibited significantly longer P300 latencies in both ears compared to their non-risk peers (p < 0.05), while no significant differences were observed in P300 amplitude. Regarding voice analysis, significant group differences were found in the F1, F2, and F3 formants during the open-ended question task (p < 0.05), suggesting alterations in speech articulation. However, vowel production parameters did not differ notably between groups. Adolescents at risk for suicide demonstrated delayed neurophysiological processing (increased P300 latency) and altered speech articulation during spontaneous speech tasks. These findings highlight the potential of integrating P300 and acoustic analysis of voice and speech as complementary markers in assessing cognitive and emotional functioning in suicide risk detection. •P300 latency was longer in adolescents at suicidal risk.•Voice formants differed in spontaneous emotional speech tasks.•No amplitude differences were found in P300 responses.•Combined P300 and voice features improved risk classification.
AbstractList Suicide remains a leading cause of external mortality, posing a significant yet preventable challenge. This study explores potential associations between suicide risk and neurophysiological (Auditory P300 Event-Related Potential) and acoustic voice and speech parameters in adolescents. The study employed a cross-sectional design. Thirty secondary school students underwent auditory assessment, P300 measurement (PEATS Eclipse EP25), and acoustic analysis of voice and speech. Suicide risk was determined using the Okasha Suicidality Scale and the Beck Depression Inventory. Acoustic analysis was performed using Praat software for phonetic research, a Focusrite Scarlett interface, and a condenser microphone to assess fundamental frequency (F0), jitter, shimmer, and formants (F1, F2, F3). Data were analyzed using IBM SPSS Statistics version 26.0 and MATLAB R2022a (MathWorks Inc.) for signal processing and feature extraction, applying both descriptive and inferential statistical methods. Adolescents at risk for suicide exhibited significantly longer P300 latencies in both ears compared to their non-risk peers (p < 0.05), while no significant differences were observed in P300 amplitude. Regarding voice analysis, significant group differences were found in the F1, F2, and F3 formants during the open-ended question task (p < 0.05), suggesting alterations in speech articulation. However, vowel production parameters did not differ notably between groups. Adolescents at risk for suicide demonstrated delayed neurophysiological processing (increased P300 latency) and altered speech articulation during spontaneous speech tasks. These findings highlight the potential of integrating P300 and acoustic analysis of voice and speech as complementary markers in assessing cognitive and emotional functioning in suicide risk detection. •P300 latency was longer in adolescents at suicidal risk.•Voice formants differed in spontaneous emotional speech tasks.•No amplitude differences were found in P300 responses.•Combined P300 and voice features improved risk classification.
ArticleNumber 101296
Author Figueroa Saavedra, Carla
Pérez, Hernán Emilio
Guillén Cañas, Virginia
Alarcón Acuña, Enzo
Méndez Bustos, Pablo
Huenupán Quinán, Fernando
Author_xml – sequence: 1
  givenname: Carla
  orcidid: 0000-0002-4184-8951
  surname: Figueroa Saavedra
  fullname: Figueroa Saavedra, Carla
  email: cfigueroa002@ikasle.ehu.eus, carla.figueroa@uautonoma.cl
  organization: Carrera de Fonoaudiología, Facultad de Ciencias de la Salud, Universidad Autónoma de Chile, Temuco, Chile
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  givenname: Fernando
  surname: Huenupán Quinán
  fullname: Huenupán Quinán, Fernando
  organization: Departamento de Ingeniería Eléctrica, Facultad de Ingeniería y Ciencias, Universidad de La Frontera, Temuco, Chile
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  givenname: Virginia
  surname: Guillén Cañas
  fullname: Guillén Cañas, Virginia
  email: virginia.guillen@ehu.eus
  organization: Departamento de Neurociencias, Facultad de Medicina y Enfermería, Universidad del País Vasco (UPV/EHU), Leioa, Spain
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  givenname: Pablo
  surname: Méndez Bustos
  fullname: Méndez Bustos, Pablo
  organization: Departamento de Psicología, Universidad Católica del Maule, Talca, Chile
– sequence: 5
  givenname: Enzo
  surname: Alarcón Acuña
  fullname: Alarcón Acuña, Enzo
  email: enzo.alarcon@uautonoma.cl
  organization: Carrera de Fonoaudiología, Facultad de Ciencias de la Salud, Universidad Autónoma de Chile, Temuco, Chile
– sequence: 6
  givenname: Hernán Emilio
  surname: Pérez
  fullname: Pérez, Hernán Emilio
  email: hperez@udec.cl
  organization: Facultad de Humanidades y Artes, Universidad de Concepción, Concepción, Chile
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Keywords Suicide risk
Speech
Acoustic parameters
Voice
P300
Language English
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Snippet Suicide remains a leading cause of external mortality, posing a significant yet preventable challenge. This study explores potential associations between...
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StartPage 101296
SubjectTerms Acoustic parameters
P300
Speech
Suicide risk
Voice
Title Auditory P300 event-related potential and acoustic features of voice and speech in adolescents at risk for suicide: A pilot study
URI https://dx.doi.org/10.1016/j.jneuroling.2025.101296
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