Effectiveness of treating post‐traumatic stress disorder in patients with co‐occurring substance use disorder with prolonged exposure, eye movement desensitization and reprocessing or imagery rescripting: A randomized controlled trial

Post-traumatic stress disorder (PTSD) and substance use disorder (SUD) are highly co-occurring and evidence for the optimal ways of treating PTSD in SUD patients is mixed. Our aim was to compare three different PTSD treatments, each added simultaneously to SUD treatment, with SUD treatment alone in...

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Vydáno v:Addiction (Abingdon, England) Ročník 120; číslo 11; s. 2231 - 2244
Hlavní autoři: Lortye, Sera, Will, Joanne P., Marquenie, Loes A., Lommerse, Nick M., Faber, Nathalie, Goudriaan, Anna E., Arntz, Arnoud, de Waal, Marleen M.
Médium: Journal Article
Jazyk:angličtina
Vydáno: England Blackwell Publishing Ltd 01.11.2025
Témata:
Addictions
Adult
Clinical trials
Combined Modality Therapy
Desensitization
Diagnostic and Statistical Manual
Disorders
Drug addiction
Drug use
Eye movement desensitization
Eye Movement Desensitization Reprocessing - methods
Eye movements
Female
Humans
Imagery
Imagery, Psychotherapy - methods
Implosive Therapy - methods
Male
Medical diagnosis
Medical treatment
Mental disorders
Middle Aged
Netherlands
Patients
Post traumatic stress disorder
Psychotherapy
Remission
Remission (Medicine)
Severity
Single-Blind Method
Stress Disorders, Post-Traumatic - complications
Stress Disorders, Post-Traumatic - therapy
Substance abuse treatment
Substance use
Substance use disorder
Substance-Related Disorders - complications
Substance-Related Disorders - epidemiology
Substance-Related Disorders - therapy
Trauma
Treatment methods
Treatment Outcome
Netherlands
substance use disorder (SUD)
prolonged exposure (PE)
eye movement desensitization and reprocessing (EMDR)
post‐traumatic stress disorder (PTSD)
imagery rescripting (ImRs)
treatment effectiveness
ISSN:0965-2140, 1360-0443, 1360-0443
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Shrnutí:Post-traumatic stress disorder (PTSD) and substance use disorder (SUD) are highly co-occurring and evidence for the optimal ways of treating PTSD in SUD patients is mixed. Our aim was to compare three different PTSD treatments, each added simultaneously to SUD treatment, with SUD treatment alone in patients with co-occurring SUD-PTSD. These PTSD treatments were: Prolonged Exposure (PE), Eye Movement Desensitization and Reprocessing (EMDR) and Imagery Rescripting (ImRs). A single-blind 4-arm randomized controlled trial with follow-up at 3 months. Two addiction treatment centers in the Netherlands, providing intra- and extramural care. 209 patients with SUD and co-morbid PTSD were included [mean age 37.5 (standard deviation, SD = 11.99), female sex = 46.4%, mean Clinically Administered PTSD Scale (CAPS) score = 37.35 (SD = 9.28)]. Participants were randomized to either simultaneous SUD + PE (n = 53), SUD + EMDR (n = 50), SUD + ImRs (n = 55) or to SUD treatment only (n = 51), with the active PTSD treatments consisting of 12 sessions each within 3 months. Standard protocols were used. The primary outcome was clinician-administered PTSD symptom severity as measured by Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (CAPS-5) at 3 month follow-up. Secondary outcomes included loss of PTSD diagnosis, full remission of PSTD and SUD-severity, also recorded at 3 months. Compared with SUD only, the mean differences in CAPS-5 score were B = -5.41 [95% confidence interval (CI) = 10.88, 0.05, P = 0.052] for SUD + PE, B = -7.97 (95% CI = -13.57, -2.37, P = 0.006) for SUD + EMDR and B = -10.03 (95% CI = -15.29, -4.77, P < 0.001) for SUD + ImRs. When adjusted for baseline covariates, mean differences were B = -5.81 (95% CI = -11.48, -0.15, P = 0.044) for SUD + PE, B = -8.85 (95% CI = -14.60, -3.10, P = 0.003) for SUD + EMDR and B = -10.75 (95% CI = -15.94, -5.56, P = <0.001) for SUD + ImRs. No between-group differences in SUD outcomes were found. Among people with co-occurring substance use disorder (SUD) and post-traumatic stress disorder (PTSD), trauma-focused PTSD treatment as add-on to SUD treatment appears to be effective in decreasing PTSD severity compared with manualized SUD only treatment and does not appear to increase SUD severity.
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ISSN:0965-2140
1360-0443
1360-0443
DOI:10.1111/add.70097