Polysaccharides extracted from tucum-do-cerrado fruits (Bactris setosa Mart) have antineoplastic effects in mice while preserving hepatic gluconeogenesis
This study investigated the antitumoral, anti-inflammatory and oxidative effects of polysaccharides from tucum (Bactris setosa, TUC) using the Ehrlich carcinoma as a tumor model. Additionally, the glycogen content, cytochrome P levels, and gluconeogenesis from lactate were assessed in the liver of h...
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| Vydáno v: | International journal of biological macromolecules Ročník 278; číslo Pt 3; s. 134590 |
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| Hlavní autoři: | , , , , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
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Netherlands
Elsevier B.V
01.10.2024
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| ISSN: | 0141-8130, 1879-0003, 1879-0003 |
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| Abstract | This study investigated the antitumoral, anti-inflammatory and oxidative effects of polysaccharides from tucum (Bactris setosa, TUC) using the Ehrlich carcinoma as a tumor model. Additionally, the glycogen content, cytochrome P levels, and gluconeogenesis from lactate were assessed in the liver of healthy animals. Tumor-bearing female mice were orally treated with 50 and 100 mg.kg−1 of TUC or vehicle, once a day, or with 1.5 mg.kg−1 methotrexate via i.p., every 3 days, along 21 days. Both doses of TUC reduced the tumor weight and volume. In the tumor tissue, it decreased GSH and IL-1β levels, and increased LPO, NAG, NO and TNF-α levels. The tumor histology showed necrosis and leukocytes infiltration. The metabolic effects of TUC were investigated by measurement of total cytochrome P (CYP) and glycogen in tumor-bearing mice, and by ex vivo liver perfusion on non-bearing tumor male mice, using lactate as gluconeogenic precursor. Metabolically, the hepatic glucose and pyruvate productions, oxygen uptake, and the total CYP concentration were not modified by TUC. Thus, tucum-do-cerrado polysaccharides have antitumor effects through the modulation of oxidative stress and inflammation, without impairing glucose production from lactate in the liver, the main organ responsible for the metabolism of organic and xenobiotic compounds.
[Display omitted]
•Polysaccharides from the fruit of the tucum-do-cerrado (TUC) are composed mainly of glucomannan and glucuronoarabinoxylan.•TUC have antitumor effects against the Ehrlich mammary tumor model in mice.•TUC treatment modulates oxidative stress and the inflammatory response in the tumor microenvironment.•TUC treatment induces necrosis in mammary tumor tissue.•TUC does not modify hepatic gluconeogenesis from lactate when perfused directly into the isolated liver of mice. |
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| AbstractList | This study investigated the antitumoral, anti-inflammatory and oxidative effects of polysaccharides from tucum (Bactris setosa, TUC) using the Ehrlich carcinoma as a tumor model. Additionally, the glycogen content, cytochrome P levels, and gluconeogenesis from lactate were assessed in the liver of healthy animals. Tumor-bearing female mice were orally treated with 50 and 100 mg.kg-1 of TUC or vehicle, once a day, or with 1.5 mg.kg-1 methotrexate via i.p., every 3 days, along 21 days. Both doses of TUC reduced the tumor weight and volume. In the tumor tissue, it decreased GSH and IL-1β levels, and increased LPO, NAG, NO and TNF-α levels. The tumor histology showed necrosis and leukocytes infiltration. The metabolic effects of TUC were investigated by measurement of total cytochrome P (CYP) and glycogen in tumor-bearing mice, and by ex vivo liver perfusion on non-bearing tumor male mice, using lactate as gluconeogenic precursor. Metabolically, the hepatic glucose and pyruvate productions, oxygen uptake, and the total CYP concentration were not modified by TUC. Thus, tucum-do-cerrado polysaccharides have antitumor effects through the modulation of oxidative stress and inflammation, without impairing glucose production from lactate in the liver, the main organ responsible for the metabolism of organic and xenobiotic compounds.This study investigated the antitumoral, anti-inflammatory and oxidative effects of polysaccharides from tucum (Bactris setosa, TUC) using the Ehrlich carcinoma as a tumor model. Additionally, the glycogen content, cytochrome P levels, and gluconeogenesis from lactate were assessed in the liver of healthy animals. Tumor-bearing female mice were orally treated with 50 and 100 mg.kg-1 of TUC or vehicle, once a day, or with 1.5 mg.kg-1 methotrexate via i.p., every 3 days, along 21 days. Both doses of TUC reduced the tumor weight and volume. In the tumor tissue, it decreased GSH and IL-1β levels, and increased LPO, NAG, NO and TNF-α levels. The tumor histology showed necrosis and leukocytes infiltration. The metabolic effects of TUC were investigated by measurement of total cytochrome P (CYP) and glycogen in tumor-bearing mice, and by ex vivo liver perfusion on non-bearing tumor male mice, using lactate as gluconeogenic precursor. Metabolically, the hepatic glucose and pyruvate productions, oxygen uptake, and the total CYP concentration were not modified by TUC. Thus, tucum-do-cerrado polysaccharides have antitumor effects through the modulation of oxidative stress and inflammation, without impairing glucose production from lactate in the liver, the main organ responsible for the metabolism of organic and xenobiotic compounds. This study investigated the antitumoral, anti-inflammatory and oxidative effects of polysaccharides from tucum (Bactris setosa, TUC) using the Ehrlich carcinoma as a tumor model. Additionally, the glycogen content, cytochrome P levels, and gluconeogenesis from lactate were assessed in the liver of healthy animals. Tumor-bearing female mice were orally treated with 50 and 100 mg.kg−1 of TUC or vehicle, once a day, or with 1.5 mg.kg−1 methotrexate via i.p., every 3 days, along 21 days. Both doses of TUC reduced the tumor weight and volume. In the tumor tissue, it decreased GSH and IL-1β levels, and increased LPO, NAG, NO and TNF-α levels. The tumor histology showed necrosis and leukocytes infiltration. The metabolic effects of TUC were investigated by measurement of total cytochrome P (CYP) and glycogen in tumor-bearing mice, and by ex vivo liver perfusion on non-bearing tumor male mice, using lactate as gluconeogenic precursor. Metabolically, the hepatic glucose and pyruvate productions, oxygen uptake, and the total CYP concentration were not modified by TUC. Thus, tucum-do-cerrado polysaccharides have antitumor effects through the modulation of oxidative stress and inflammation, without impairing glucose production from lactate in the liver, the main organ responsible for the metabolism of organic and xenobiotic compounds. [Display omitted] •Polysaccharides from the fruit of the tucum-do-cerrado (TUC) are composed mainly of glucomannan and glucuronoarabinoxylan.•TUC have antitumor effects against the Ehrlich mammary tumor model in mice.•TUC treatment modulates oxidative stress and the inflammatory response in the tumor microenvironment.•TUC treatment induces necrosis in mammary tumor tissue.•TUC does not modify hepatic gluconeogenesis from lactate when perfused directly into the isolated liver of mice. This study investigated the antitumoral, anti-inflammatory and oxidative effects of polysaccharides from tucum (Bactris setosa, TUC) using the Ehrlich carcinoma as a tumor model. Additionally, the glycogen content, cytochrome P levels, and gluconeogenesis from lactate were assessed in the liver of healthy animals. Tumor-bearing female mice were orally treated with 50 and 100 mg.kg of TUC or vehicle, once a day, or with 1.5 mg.kg methotrexate via i.p., every 3 days, along 21 days. Both doses of TUC reduced the tumor weight and volume. In the tumor tissue, it decreased GSH and IL-1β levels, and increased LPO, NAG, NO and TNF-α levels. The tumor histology showed necrosis and leukocytes infiltration. The metabolic effects of TUC were investigated by measurement of total cytochrome P (CYP) and glycogen in tumor-bearing mice, and by ex vivo liver perfusion on non-bearing tumor male mice, using lactate as gluconeogenic precursor. Metabolically, the hepatic glucose and pyruvate productions, oxygen uptake, and the total CYP concentration were not modified by TUC. Thus, tucum-do-cerrado polysaccharides have antitumor effects through the modulation of oxidative stress and inflammation, without impairing glucose production from lactate in the liver, the main organ responsible for the metabolism of organic and xenobiotic compounds. |
| ArticleNumber | 134590 |
| Author | Comar, Jurandir Fernando de Assis, Camila Bach Galindo, Claudia Martins de Oliveira, Kauê Marcel Acco, Alexandra Pereira, Gabriela Saidel Stipp, Maria Carolina do Amaral, Luane Aparecida Cordeiro, Lucimara Mach Côrtes Corso, Claudia Rita Faria, Bruna Christ Abboud, Kahlile Youseff Radulski, Débora Rasec de Lima Martins, Juliana Nunes |
| Author_xml | – sequence: 1 givenname: Kauê Marcel surname: de Oliveira fullname: de Oliveira, Kauê Marcel organization: Department of Pharmacology, Federal University of Paraná, Curitiba, PR, Brazil – sequence: 2 givenname: Kahlile Youseff surname: Abboud fullname: Abboud, Kahlile Youseff organization: Department of Biochemistry and Molecular Biology, Federal University of Paraná, Curitiba, PR, Brazil – sequence: 3 givenname: Débora Rasec surname: Radulski fullname: Radulski, Débora Rasec organization: Department of Pharmacology, Federal University of Paraná, Curitiba, PR, Brazil – sequence: 4 givenname: Bruna Christ surname: Faria fullname: Faria, Bruna Christ organization: Department of Pharmacology, Federal University of Paraná, Curitiba, PR, Brazil – sequence: 5 givenname: Claudia Martins surname: Galindo fullname: Galindo, Claudia Martins organization: Department of Pharmacology, Federal University of Paraná, Curitiba, PR, Brazil – sequence: 6 givenname: Gabriela Saidel surname: Pereira fullname: Pereira, Gabriela Saidel organization: Department of Pharmacology, Federal University of Paraná, Curitiba, PR, Brazil – sequence: 7 givenname: Maria Carolina surname: Stipp fullname: Stipp, Maria Carolina organization: Department of Pharmacology, Federal University of Paraná, Curitiba, PR, Brazil – sequence: 8 givenname: Claudia Rita surname: Corso fullname: Corso, Claudia Rita organization: Department of Pharmacology, Federal University of Paraná, Curitiba, PR, Brazil – sequence: 9 givenname: Camila Bach surname: de Assis fullname: de Assis, Camila Bach organization: Department of Pharmacology, Federal University of Paraná, Curitiba, PR, Brazil – sequence: 10 givenname: Juliana Nunes surname: de Lima Martins fullname: de Lima Martins, Juliana Nunes organization: Department of Biochemistry, State University of Maringá, Maringá, PR, Brazil – sequence: 11 givenname: Luane Aparecida surname: do Amaral fullname: do Amaral, Luane Aparecida organization: Postgraduate Program in Health and Development in the Midwest Region, Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil – sequence: 12 givenname: Jurandir Fernando surname: Comar fullname: Comar, Jurandir Fernando organization: Department of Biochemistry, State University of Maringá, Maringá, PR, Brazil – sequence: 13 givenname: Lucimara Mach Côrtes surname: Cordeiro fullname: Cordeiro, Lucimara Mach Côrtes organization: Department of Biochemistry and Molecular Biology, Federal University of Paraná, Curitiba, PR, Brazil – sequence: 14 givenname: Alexandra surname: Acco fullname: Acco, Alexandra email: aleacco@ufpr.br organization: Department of Pharmacology, Federal University of Paraná, Curitiba, PR, Brazil |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/39127269$$D View this record in MEDLINE/PubMed |
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| Issue | Pt 3 |
| Keywords | Soluble dietary fibers Oxidative stress Inflammation Tucum palm fruits Cancer Gluconeogenesis |
| Language | English |
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| SubjectTerms | Cancer Gluconeogenesis Inflammation Oxidative stress Soluble dietary fibers Tucum palm fruits |
| Title | Polysaccharides extracted from tucum-do-cerrado fruits (Bactris setosa Mart) have antineoplastic effects in mice while preserving hepatic gluconeogenesis |
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