An in vivo screening platform identifies senolytic compounds that target p16INK4a+ fibroblasts in lung fibrosis

The appearance of senescent cells in age-related diseases has spurred the search for compounds that can target senescent cells in tissues ("senolytics"). However, a major caveat with current senolytic screens is the use of cell lines as targets where senescence is induced in vitro, which d...

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Bibliographic Details
Published in:	The Journal of clinical investigation Vol. 134; no. 9; pp. 1 - 16
Main Authors:	Lee, Jin Young, Reyes, Nabora S., Ravishankar, Supriya, Zhou, Minqi, Krasilnikov, Maria, Ringler, Christian, Pohan, Grace, Wilson, Chris, Ang, Kenny Kean-Hooi, Wolters, Paul J., Tsukui, Tatsuya, Sheppard, Dean, Arkin, Michelle R., Peng, Tien
Format:	Journal Article
Language:	English
Published:	United States American Society for Clinical Investigation 01.05.2024
Subjects:	Age Aging Animal models Biomarkers Cell lines Cells Fibroblasts Fibrosis Gene expression High-throughput screening Hsp90 protein INK4a protein Lung diseases Lungs p16 Protein Pulmonary fibrosis Pulmonology Senescence Pulmonology Aging Cellular senescence Fibrosis Drug screens
ISSN:	1558-8238, 0021-9738, 1558-8238
Online Access:	Get full text
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