Redondoviridae, a Family of Small, Circular DNA Viruses of the Human Oro-Respiratory Tract Associated with Periodontitis and Critical Illness
The global virome is largely uncharacterized but is now being unveiled by metagenomic DNA sequencing. Exploring the human respiratory virome, in particular, can provide insights into oro-respiratory diseases. Here, we use metagenomics to identify a family of small circular DNA viruses-named Redondov...
Uloženo v:
| Vydáno v: | Cell host & microbe Ročník 25; číslo 5; s. 719 |
|---|---|
| Hlavní autoři: | , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
United States
08.05.2019
|
| Témata: | |
| ISSN: | 1934-6069, 1934-6069 |
| On-line přístup: | Zjistit podrobnosti o přístupu |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Abstract | The global virome is largely uncharacterized but is now being unveiled by metagenomic DNA sequencing. Exploring the human respiratory virome, in particular, can provide insights into oro-respiratory diseases. Here, we use metagenomics to identify a family of small circular DNA viruses-named Redondoviridae-associated with human diseases. We first identified two redondovirus genomes from bronchoalveolar lavage samples from human lung donors. We then queried thousands of metagenomic samples and recovered 17 additional complete redondovirus genomes. Detections were exclusively in human samples and mostly from respiratory tract and oro-pharyngeal sites, where Redondoviridae was the second most prevalent eukaryotic DNA virus family. Redondovirus sequences were associated with periodontal disease, and abundances decreased with treatment. Some critically ill patients in a medical intensive care unit were found to harbor high levels of redondoviruses in respiratory samples. These results suggest that redondoviruses colonize human oro-respiratory sites and can bloom in several human disorders. |
|---|---|
| AbstractList | The global virome is largely uncharacterized but is now being unveiled by metagenomic DNA sequencing. Exploring the human respiratory virome, in particular, can provide insights into oro-respiratory diseases. Here, we use metagenomics to identify a family of small circular DNA viruses-named Redondoviridae-associated with human diseases. We first identified two redondovirus genomes from bronchoalveolar lavage samples from human lung donors. We then queried thousands of metagenomic samples and recovered 17 additional complete redondovirus genomes. Detections were exclusively in human samples and mostly from respiratory tract and oro-pharyngeal sites, where Redondoviridae was the second most prevalent eukaryotic DNA virus family. Redondovirus sequences were associated with periodontal disease, and abundances decreased with treatment. Some critically ill patients in a medical intensive care unit were found to harbor high levels of redondoviruses in respiratory samples. These results suggest that redondoviruses colonize human oro-respiratory sites and can bloom in several human disorders.The global virome is largely uncharacterized but is now being unveiled by metagenomic DNA sequencing. Exploring the human respiratory virome, in particular, can provide insights into oro-respiratory diseases. Here, we use metagenomics to identify a family of small circular DNA viruses-named Redondoviridae-associated with human diseases. We first identified two redondovirus genomes from bronchoalveolar lavage samples from human lung donors. We then queried thousands of metagenomic samples and recovered 17 additional complete redondovirus genomes. Detections were exclusively in human samples and mostly from respiratory tract and oro-pharyngeal sites, where Redondoviridae was the second most prevalent eukaryotic DNA virus family. Redondovirus sequences were associated with periodontal disease, and abundances decreased with treatment. Some critically ill patients in a medical intensive care unit were found to harbor high levels of redondoviruses in respiratory samples. These results suggest that redondoviruses colonize human oro-respiratory sites and can bloom in several human disorders. The global virome is largely uncharacterized but is now being unveiled by metagenomic DNA sequencing. Exploring the human respiratory virome, in particular, can provide insights into oro-respiratory diseases. Here, we use metagenomics to identify a family of small circular DNA viruses-named Redondoviridae-associated with human diseases. We first identified two redondovirus genomes from bronchoalveolar lavage samples from human lung donors. We then queried thousands of metagenomic samples and recovered 17 additional complete redondovirus genomes. Detections were exclusively in human samples and mostly from respiratory tract and oro-pharyngeal sites, where Redondoviridae was the second most prevalent eukaryotic DNA virus family. Redondovirus sequences were associated with periodontal disease, and abundances decreased with treatment. Some critically ill patients in a medical intensive care unit were found to harbor high levels of redondoviruses in respiratory samples. These results suggest that redondoviruses colonize human oro-respiratory sites and can bloom in several human disorders. |
| Author | Fitzgerald, Ayannah S Collman, Ronald G Khatib, Layla A Abbas, Arwa A Taylor, Louis J Leiby, Jacob S Dothard, Marisol I Bushman, Frederic D |
| Author_xml | – sequence: 1 givenname: Arwa A surname: Abbas fullname: Abbas, Arwa A organization: Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA – sequence: 2 givenname: Louis J surname: Taylor fullname: Taylor, Louis J organization: Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA – sequence: 3 givenname: Marisol I surname: Dothard fullname: Dothard, Marisol I organization: Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA – sequence: 4 givenname: Jacob S surname: Leiby fullname: Leiby, Jacob S organization: Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA – sequence: 5 givenname: Ayannah S surname: Fitzgerald fullname: Fitzgerald, Ayannah S organization: Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA – sequence: 6 givenname: Layla A surname: Khatib fullname: Khatib, Layla A organization: Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA – sequence: 7 givenname: Ronald G surname: Collman fullname: Collman, Ronald G email: collmanr@pennmedicine.upenn.edu organization: Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA. Electronic address: collmanr@pennmedicine.upenn.edu – sequence: 8 givenname: Frederic D surname: Bushman fullname: Bushman, Frederic D email: bushman@pennmedicine.upenn.edu organization: Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA. Electronic address: bushman@pennmedicine.upenn.edu |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31071295$$D View this record in MEDLINE/PubMed |
| BookMark | eNpNkE1LxDAYhIMo7of-AQ-So4dtTZo0uz0uq6uCqPh1Xd4mb9ksabMmrbI_wv9sRQVPMzAPMzAjst_4Bgk54SzljKvzTarXvk4zxouUyZQxvkeGvBAyUUwV-__8gIxi3DCW52zKD8lA8F6zIh-Sz0c0vjH-3QZrACcU6BJq63bUV_SpBucmdGGD7hwEenE3p682dBHjd9yukV53NTT0PvjkEePWBmh92NHnALql8xi9ttCioR-2XdMHDNb3a61tbaTQGLoIvdXg6I1zDcZ4RA4qcBGPf3VMXpaXz4vr5Pb-6mYxv0204DlPJIOZVLnIihLBIGrBmBaCQaVKBZKLWSmn0gA3JU4l5pIZUWksK6WMKVWRjcnZT-82-LcOY7uqbdToHDTou7jKMtF_x6T8Rk9_0a6s0ay2wdYQdqu_C7MvcSF3tQ |
| CitedBy_id | crossref_primary_10_3390_v12090995 crossref_primary_10_1007_s00284_023_03537_0 crossref_primary_10_1038_s41588_024_02022_z crossref_primary_10_1128_msystems_01169_23 crossref_primary_10_1186_s12879_024_09523_6 crossref_primary_10_1053_j_seminhematol_2020_05_001 crossref_primary_10_35366_102966 crossref_primary_10_31435_ijitss_3_47__2025_3545 crossref_primary_10_3390_ijms20235861 crossref_primary_10_3390_v15010236 crossref_primary_10_3390_microorganisms12091797 crossref_primary_10_1099_jgv_0_001706 crossref_primary_10_1016_j_heliyon_2023_e14086 crossref_primary_10_3389_fmicb_2022_963488 crossref_primary_10_1016_j_coviro_2022_101248 crossref_primary_10_1128_MRA_00273_21 crossref_primary_10_1038_s41467_020_18474_w crossref_primary_10_1093_ve_veac087 crossref_primary_10_1080_17476348_2021_1893168 crossref_primary_10_1038_s41564_025_02115_3 crossref_primary_10_3390_v12030327 crossref_primary_10_1007_s10096_025_05140_6 crossref_primary_10_1016_j_chom_2019_04_010 crossref_primary_10_1038_s41522_024_00554_0 crossref_primary_10_3390_jcm13010171 crossref_primary_10_1038_s41392_023_01722_y crossref_primary_10_1038_s41579_021_00536_5 crossref_primary_10_1016_j_crmeth_2021_100091 crossref_primary_10_3390_v11121092 crossref_primary_10_1038_s41467_023_36336_z crossref_primary_10_1172_JCI150473 crossref_primary_10_1038_s41577_024_01100_x crossref_primary_10_3390_diagnostics15111431 crossref_primary_10_1128_JVI_00817_21 crossref_primary_10_3389_fvets_2025_1617147 crossref_primary_10_3390_ijms24076303 crossref_primary_10_7717_peerj_16947 crossref_primary_10_1038_s43705_023_00338_1 crossref_primary_10_1080_19490976_2024_2351478 crossref_primary_10_3389_fmicb_2022_895537 crossref_primary_10_1186_s13059_020_02020_4 crossref_primary_10_3390_v17010086 crossref_primary_10_1038_s41579_023_00963_6 crossref_primary_10_1128_spectrum_04798_22 crossref_primary_10_3390_v15091821 crossref_primary_10_3390_ijms24043897 crossref_primary_10_1128_JVI_00582_20 crossref_primary_10_1111_jeb_13927 crossref_primary_10_1128_spectrum_01610_22 crossref_primary_10_1016_j_virusres_2021_198501 crossref_primary_10_1128_jvi_01112_25 crossref_primary_10_1371_journal_pone_0289923 crossref_primary_10_3389_fimmu_2022_932228 crossref_primary_10_1007_s40496_020_00251_9 crossref_primary_10_1016_j_ijid_2025_107896 crossref_primary_10_1371_journal_pntd_0012536 crossref_primary_10_3389_fimmu_2022_885341 crossref_primary_10_1128_spectrum_00702_23 crossref_primary_10_3389_fmicb_2023_1190172 crossref_primary_10_1371_journal_pone_0291027 crossref_primary_10_3389_fpls_2020_558403 crossref_primary_10_3390_v13040533 crossref_primary_10_1111_prd_12435 crossref_primary_10_1186_s12985_025_02742_6 crossref_primary_10_1016_j_healun_2021_04_014 crossref_primary_10_1099_jgv_0_001526 crossref_primary_10_3390_v14112482 crossref_primary_10_1111_1348_0421_13033 crossref_primary_10_3390_microorganisms9071357 crossref_primary_10_3389_fimmu_2022_1005107 crossref_primary_10_1016_j_jcv_2020_104586 crossref_primary_10_3390_v16020228 crossref_primary_10_3390_vaccines13090895 |
| ContentType | Journal Article |
| Copyright | Copyright © 2019 Elsevier Inc. All rights reserved. |
| Copyright_xml | – notice: Copyright © 2019 Elsevier Inc. All rights reserved. |
| DBID | CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1016/j.chom.2019.04.001 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | no_fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 1934-6069 |
| ExternalDocumentID | 31071295 |
| Genre | Journal Article |
| GrantInformation_xml | – fundername: NHLBI NIH HHS grantid: R01 HL113252 – fundername: NIAID NIH HHS grantid: T32 AI007324 – fundername: NHLBI NIH HHS grantid: R61 HL137063 – fundername: NHLBI NIH HHS grantid: R33 HL137063 – fundername: NCI NIH HHS grantid: P01 CA077760 |
| GroupedDBID | --- --K 0R~ 1~5 29B 2WC 4.4 457 4G. 53G 5GY 62- 6J9 7-5 AACTN AAEDT AAEDW AAKRW AAMRU AAVLU AAXUO ABJNI ABMAC ACGFO ACGFS ADBBV ADEZE ADVLN AEFWE AENEX AEXQZ AFTJW AGCQF AGKMS AITUG AKAPO AKRWK ALMA_UNASSIGNED_HOLDINGS AMRAJ APXCP ASPBG AVWKF AZFZN BAWUL CGR CS3 CUY CVF DIK DU5 E3Z EBS ECM EIF EJD F5P FCP FDB FEDTE HVGLF IHE IXB JIG M41 NPM O-L O9- OK1 P2P RIG ROL RPZ SES SSZ TR2 UNMZH 7X8 AALRI AAYWO ABDGV ACVFH ADCNI AEUPX AFPUW AIGII AKBMS AKYEP EFKBS |
| ID | FETCH-LOGICAL-c3151-40a8465329beadeec300c330af6b6a4138b474da1dbe74e540d3fcebf66ddb692 |
| IEDL.DBID | 7X8 |
| ISSN | 1934-6069 |
| IngestDate | Sun Sep 28 03:02:28 EDT 2025 Tue Apr 29 09:42:33 EDT 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 5 |
| Keywords | redondoviridae virome vientovirus brisavirus critical illness CRESS DNA periodontitis viral metagenomics oro-respiratory virus redondovirus |
| Language | English |
| License | Copyright © 2019 Elsevier Inc. All rights reserved. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c3151-40a8465329beadeec300c330af6b6a4138b474da1dbe74e540d3fcebf66ddb692 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | http://www.cell.com/article/S1931312819301714/pdf |
| PMID | 31071295 |
| PQID | 2231930449 |
| PQPubID | 23479 |
| ParticipantIDs | proquest_miscellaneous_2231930449 pubmed_primary_31071295 |
| PublicationCentury | 2000 |
| PublicationDate | 2019-05-08 |
| PublicationDateYYYYMMDD | 2019-05-08 |
| PublicationDate_xml | – month: 05 year: 2019 text: 2019-05-08 day: 08 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Cell host & microbe |
| PublicationTitleAlternate | Cell Host Microbe |
| PublicationYear | 2019 |
| References | 31415757 - Cell Host Microbe. 2019 Aug 14;26(2):297 |
| References_xml | – reference: 31415757 - Cell Host Microbe. 2019 Aug 14;26(2):297 |
| SSID | ssj0055071 |
| Score | 2.5481164 |
| Snippet | The global virome is largely uncharacterized but is now being unveiled by metagenomic DNA sequencing. Exploring the human respiratory virome, in particular,... The global virome is largely uncharacterized but is now being unveiled by metagenomic DNA sequencing. Exploring the human respiratory virome, in particular,... |
| SourceID | proquest pubmed |
| SourceType | Aggregation Database Index Database |
| StartPage | 719 |
| SubjectTerms | Adult Aged Aged, 80 and over Critical Illness DNA Virus Infections - virology DNA Viruses - classification DNA Viruses - genetics DNA Viruses - isolation & purification DNA Viruses - pathogenicity DNA, Circular - genetics DNA, Viral - genetics Female Humans Male Metagenomics Middle Aged Mouth - virology Periodontitis - virology Respiratory System - virology Young Adult |
| Title | Redondoviridae, a Family of Small, Circular DNA Viruses of the Human Oro-Respiratory Tract Associated with Periodontitis and Critical Illness |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/31071295 https://www.proquest.com/docview/2231930449 |
| Volume | 25 |
| hasFullText | |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LS8NAEF7UKnjx_agvRvDYYB7bbHKSUi0KWkut0lvZV6BQk5rQgj_C_-zsJrUnQfCSS8gm7H6Z-XZmdj5CrqRE1ip402kqhhsUTkOHq0g7Ohbc9zRDzmxb5j-ybjcaDuNeFXArqrLKhU20hlpl0sTIr9GNIddwKY1vph-OUY0y2dVKQmOV1AKkMgbVbPiTRTCturwyq0wdfGlcHZop67uMFokp7Yptq1PX-51iWlfT2f7vR-6QrYpkQqtExS5Z0eke2ShlJz_3yVdfK6PiMR_nY8V1AziU-heQJfDyzieTBrTHua1QhdtuC97G-azQhbmNfBFs4B-e88zpLxP1MDDnrWCx3FqBCfFCDxGOO1_bubUAnipYiCvAw2Ri7OwBee3cDdr3TiXL4MgA-QHuOHlkurL5sTDV1loGriuDwOVJKEKOTjESlFHFPSU0oxopoQoSqUUShkqJMPYPyVqapfqYgFAaIcE9mciI-okfs0QIqhjloVA4bJ1cLuZ5hLA3uQye6mxWjJYzXSdH5WKNpmV_jhEyVoY0pnnyh6dPyabBgC1hjM5ILcGfXp-TdTnHWckvLJ7w2u09fQOFrdeI |
| linkProvider | ProQuest |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Redondoviridae%2C+a+Family+of+Small%2C+Circular+DNA+Viruses+of+the+Human+Oro-Respiratory+Tract+Associated+with+Periodontitis+and+Critical+Illness&rft.jtitle=Cell+host+%26+microbe&rft.au=Abbas%2C+Arwa+A&rft.au=Taylor%2C+Louis+J&rft.au=Dothard%2C+Marisol+I&rft.au=Leiby%2C+Jacob+S&rft.date=2019-05-08&rft.issn=1934-6069&rft.eissn=1934-6069&rft.volume=25&rft.issue=5&rft.spage=719&rft_id=info:doi/10.1016%2Fj.chom.2019.04.001&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1934-6069&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1934-6069&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1934-6069&client=summon |