Precision cancer therapy: profiting from tumor specific defects in the DNA damage tolerance system

DNA damage tolerance (DDT) enables replication to continue in the presence of a damaged template and constitutes a key step in DNA interstrand crosslink repair. In this way DDT minimizes replication stress inflicted by a wide range of endogenous and exogenous agents, and provides a critical first li...

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Bibliographic Details

Published in:	Oncotarget Vol. 9; no. 27; p. 18832
Main Authors:	Buoninfante, Olimpia Alessandra, Pilzecker, Bas, Aslam, Muhammad Assad, Zavrakidis, Ioannis, van der Wiel, Rianne, van de Ven, Marieke, van den Berk, Paul C M, Jacobs, Heinz
Format:	Journal Article
Language:	English
Published:	United States 10.04.2018
Subjects:	precision cancer medicine DNA damage tolerance cancer target cisplatin chemotherapy
ISSN:	1949-2553, 1949-2553
Online Access:	Get more information
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