Molecular mechanisms of long noncoding RNAs and their role in disease pathogenesis
LncRNAs are long non-coding regulatory RNAs that are longer than 200 nucleotides. One of the major functions of lncRNAs is the regulation of specific gene expression at multiple steps including, recruitment and expression of basal transcription machinery, post-transcriptional modifications and epige...
Saved in:
| Published in: | Oncotarget Vol. 9; no. 26; p. 18648 |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
06.04.2018
|
| Subjects: | |
| ISSN: | 1949-2553, 1949-2553 |
| Online Access: | Get more information |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | LncRNAs are long non-coding regulatory RNAs that are longer than 200 nucleotides. One of the major functions of lncRNAs is the regulation of specific gene expression at multiple steps including, recruitment and expression of basal transcription machinery, post-transcriptional modifications and epigenetics [1]. Emerging evidence suggests that lncRNAs also play a critical role in maintaining tissue homeostasis during physiological and pathological conditions, lipid homeostasis, as well as epithelial and smooth muscle cell homeostasis, a topic that has been elegantly reviewed [2-5]. While aberrant expression of lncRNAs has been implicated in several disease conditions, there is paucity of information about their contribution to the etiology of diseases [6]. Several studies have compared the expression of lncRNAs under normal and cancerous conditions and found differential expression of several lncRNAs, suggesting thereby an involvement of lncRNAs in disease processes [7, 8]. Furthermore, the ability of lncRNAs to influence epigenetic changes also underlies their role in disease pathogenesis since epigenetic regulation is known to play a critical role in many human diseases [1]. LncRNAs thus are not only involved in homeostatic functioning but also play a vital role in the progression of many diseases, thereby underscoring their potential as novel therapeutic targets for the alleviation of a variety of human disease conditions. |
|---|---|
| AbstractList | LncRNAs are long non-coding regulatory RNAs that are longer than 200 nucleotides. One of the major functions of lncRNAs is the regulation of specific gene expression at multiple steps including, recruitment and expression of basal transcription machinery, post-transcriptional modifications and epigenetics [1]. Emerging evidence suggests that lncRNAs also play a critical role in maintaining tissue homeostasis during physiological and pathological conditions, lipid homeostasis, as well as epithelial and smooth muscle cell homeostasis, a topic that has been elegantly reviewed [2-5]. While aberrant expression of lncRNAs has been implicated in several disease conditions, there is paucity of information about their contribution to the etiology of diseases [6]. Several studies have compared the expression of lncRNAs under normal and cancerous conditions and found differential expression of several lncRNAs, suggesting thereby an involvement of lncRNAs in disease processes [7, 8]. Furthermore, the ability of lncRNAs to influence epigenetic changes also underlies their role in disease pathogenesis since epigenetic regulation is known to play a critical role in many human diseases [1]. LncRNAs thus are not only involved in homeostatic functioning but also play a vital role in the progression of many diseases, thereby underscoring their potential as novel therapeutic targets for the alleviation of a variety of human disease conditions.LncRNAs are long non-coding regulatory RNAs that are longer than 200 nucleotides. One of the major functions of lncRNAs is the regulation of specific gene expression at multiple steps including, recruitment and expression of basal transcription machinery, post-transcriptional modifications and epigenetics [1]. Emerging evidence suggests that lncRNAs also play a critical role in maintaining tissue homeostasis during physiological and pathological conditions, lipid homeostasis, as well as epithelial and smooth muscle cell homeostasis, a topic that has been elegantly reviewed [2-5]. While aberrant expression of lncRNAs has been implicated in several disease conditions, there is paucity of information about their contribution to the etiology of diseases [6]. Several studies have compared the expression of lncRNAs under normal and cancerous conditions and found differential expression of several lncRNAs, suggesting thereby an involvement of lncRNAs in disease processes [7, 8]. Furthermore, the ability of lncRNAs to influence epigenetic changes also underlies their role in disease pathogenesis since epigenetic regulation is known to play a critical role in many human diseases [1]. LncRNAs thus are not only involved in homeostatic functioning but also play a vital role in the progression of many diseases, thereby underscoring their potential as novel therapeutic targets for the alleviation of a variety of human disease conditions. LncRNAs are long non-coding regulatory RNAs that are longer than 200 nucleotides. One of the major functions of lncRNAs is the regulation of specific gene expression at multiple steps including, recruitment and expression of basal transcription machinery, post-transcriptional modifications and epigenetics [1]. Emerging evidence suggests that lncRNAs also play a critical role in maintaining tissue homeostasis during physiological and pathological conditions, lipid homeostasis, as well as epithelial and smooth muscle cell homeostasis, a topic that has been elegantly reviewed [2-5]. While aberrant expression of lncRNAs has been implicated in several disease conditions, there is paucity of information about their contribution to the etiology of diseases [6]. Several studies have compared the expression of lncRNAs under normal and cancerous conditions and found differential expression of several lncRNAs, suggesting thereby an involvement of lncRNAs in disease processes [7, 8]. Furthermore, the ability of lncRNAs to influence epigenetic changes also underlies their role in disease pathogenesis since epigenetic regulation is known to play a critical role in many human diseases [1]. LncRNAs thus are not only involved in homeostatic functioning but also play a vital role in the progression of many diseases, thereby underscoring their potential as novel therapeutic targets for the alleviation of a variety of human disease conditions. |
| Author | Niu, Fang Liao, Ke Callen, Shannon Bendi, Sunil Fox, Howard S Buch, Shilpa Humburg, Bree A Hu, Guoku |
| Author_xml | – sequence: 1 givenname: Guoku surname: Hu fullname: Hu, Guoku organization: Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA – sequence: 2 givenname: Fang surname: Niu fullname: Niu, Fang organization: Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA – sequence: 3 givenname: Bree A surname: Humburg fullname: Humburg, Bree A organization: Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA – sequence: 4 givenname: Ke surname: Liao fullname: Liao, Ke organization: Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA – sequence: 5 givenname: Sunil surname: Bendi fullname: Bendi, Sunil organization: Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA – sequence: 6 givenname: Shannon surname: Callen fullname: Callen, Shannon organization: Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA – sequence: 7 givenname: Howard S surname: Fox fullname: Fox, Howard S organization: Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA – sequence: 8 givenname: Shilpa surname: Buch fullname: Buch, Shilpa organization: Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29719633$$D View this record in MEDLINE/PubMed |
| BookMark | eNpNUDtPwzAYtFARLaU_gAV5ZEmxPztxPVYVL6mAVMEcOfHn1iixS5wM_HtaUSRuuRvuId0lGYUYkJBrzuZ8UQi4i6GOvem22M9BCqbOyIRrqTPIczH6p8dkltInOyCXagH6goxBK64LISZk8xIbrIfGdLTFemeCT22i0dEmhi0Nxw3rD2rzukzUBEv7HfqOdocU9YFan9AkpHvT7-IWAyafrsi5M03C2Ymn5OPh_n31lK3fHp9Xy3VWCy5VZpyUrEZhFhqcAS0dA255rZR10sjcOQkFVBWXR7DcVTrXUHCreFGxysKU3P727rv4NWDqy9anGpvGBIxDKoEJCVooxQ_Wm5N1qFq05b7zrem-y78f4AekzGN4 |
| CitedBy_id | crossref_primary_10_1007_s12035_023_03626_y crossref_primary_10_3389_fgene_2019_00680 crossref_primary_10_1186_s12864_022_08805_0 crossref_primary_10_1016_j_cca_2022_12_010 crossref_primary_10_1007_s11033_025_10975_5 crossref_primary_10_1038_s41419_022_04717_9 crossref_primary_10_1111_jcmm_17014 crossref_primary_10_3390_genes16040420 crossref_primary_10_1038_s41598_023_37898_0 crossref_primary_10_4331_wjbc_v11_i2_62 crossref_primary_10_1097_MD_0000000000033075 crossref_primary_10_7554_eLife_81360 crossref_primary_10_1097_MD_0000000000027178 crossref_primary_10_1007_s12038_023_00349_z crossref_primary_10_1016_j_lfs_2019_116731 crossref_primary_10_3390_biom10071044 crossref_primary_10_1016_j_chembiol_2021_03_003 crossref_primary_10_3390_cancers13122979 crossref_primary_10_1186_s12864_020_07055_2 crossref_primary_10_3892_mmr_2019_9906 crossref_primary_10_1016_j_jpsychires_2023_06_017 crossref_primary_10_1016_j_imlet_2020_08_001 crossref_primary_10_1016_j_cca_2025_120265 crossref_primary_10_1016_j_arr_2019_01_001 crossref_primary_10_3390_ijms20194898 crossref_primary_10_3389_fphar_2020_00641 crossref_primary_10_1089_cbr_2020_4429 crossref_primary_10_1016_j_jid_2021_09_031 crossref_primary_10_1155_2021_9978882 crossref_primary_10_1016_j_cca_2018_10_002 crossref_primary_10_1016_j_humgen_2025_201469 crossref_primary_10_1080_09674845_2019_1675847 crossref_primary_10_3389_fonc_2021_822745 crossref_primary_10_1038_s41598_020_80291_4 crossref_primary_10_3389_fgene_2020_628539 crossref_primary_10_1111_jcmm_14087 crossref_primary_10_3389_fgene_2023_1024444 crossref_primary_10_1016_j_arr_2024_102556 crossref_primary_10_1080_09168451_2019_1673695 crossref_primary_10_1515_hmbci_2023_0012 crossref_primary_10_1371_journal_pone_0258194 crossref_primary_10_3390_cells8091015 crossref_primary_10_3390_biom15091255 crossref_primary_10_1016_j_gene_2019_03_066 crossref_primary_10_3390_genes9090437 crossref_primary_10_1016_j_trsl_2020_11_010 crossref_primary_10_1002_jcb_29542 crossref_primary_10_1016_j_brainresbull_2020_04_017 crossref_primary_10_1016_j_jconrel_2023_04_001 crossref_primary_10_1111_iep_70003 crossref_primary_10_1016_j_biopha_2020_110570 crossref_primary_10_1111_1759_7714_13928 crossref_primary_10_1002_jcb_28611 crossref_primary_10_1016_j_fsi_2018_07_020 crossref_primary_10_1016_j_jbi_2018_11_013 crossref_primary_10_3390_ijms25105507 crossref_primary_10_1002_cbf_3748 crossref_primary_10_1096_fj_202400973RR crossref_primary_10_1093_bfgp_elad049 crossref_primary_10_1016_j_ijbiomac_2024_130426 crossref_primary_10_2217_rme_2020_0174 crossref_primary_10_1155_2022_9273628 crossref_primary_10_1007_s10142_024_01444_6 crossref_primary_10_3892_or_2021_8137 crossref_primary_10_1093_jb_mvy118 crossref_primary_10_3390_ijms21186658 crossref_primary_10_1016_j_psj_2024_104376 crossref_primary_10_3390_ijms21041193 crossref_primary_10_1002_jcb_28701 crossref_primary_10_1155_2022_5038124 crossref_primary_10_1186_s13045_018_0673_6 crossref_primary_10_3389_fcvm_2023_1155767 crossref_primary_10_3389_fonc_2021_687629 crossref_primary_10_1155_2019_7159592 crossref_primary_10_1007_s12029_021_00744_5 crossref_primary_10_1016_j_prp_2023_154852 crossref_primary_10_3390_cells13110898 crossref_primary_10_1007_s10528_021_10055_w crossref_primary_10_1128_JVI_00698_21 crossref_primary_10_3390_jcm13103016 crossref_primary_10_1186_s40364_021_00307_7 crossref_primary_10_1016_j_critrevonc_2025_104892 crossref_primary_10_1016_j_drup_2020_100683 crossref_primary_10_1186_s12967_022_03550_0 crossref_primary_10_2174_1574893618666230914160213 crossref_primary_10_1016_j_molimm_2020_10_022 crossref_primary_10_1158_2326_6066_CIR_19_0696 crossref_primary_10_1016_j_prp_2018_12_026 crossref_primary_10_1016_j_bbagrm_2024_195061 crossref_primary_10_1186_s12964_024_01475_3 crossref_primary_10_1039_C8RA05724A crossref_primary_10_3389_fcimb_2020_00361 crossref_primary_10_3390_biom11081132 crossref_primary_10_1016_j_biopha_2020_110362 crossref_primary_10_1016_j_gene_2018_09_031 crossref_primary_10_1007_s11033_018_4276_7 crossref_primary_10_3389_fimmu_2020_01747 crossref_primary_10_3390_cancers13061274 crossref_primary_10_3389_fonc_2020_614455 crossref_primary_10_3389_fphar_2022_873271 crossref_primary_10_1007_s00284_021_02590_x crossref_primary_10_1016_j_cellsig_2019_109509 crossref_primary_10_1016_j_psj_2024_103715 crossref_primary_10_1134_S199075082460016X crossref_primary_10_1016_j_virusres_2020_197907 crossref_primary_10_1016_j_canlet_2022_215763 crossref_primary_10_1016_j_jid_2019_04_021 crossref_primary_10_1016_j_canlet_2022_215645 crossref_primary_10_1016_j_prp_2024_155540 crossref_primary_10_1186_s12920_021_00994_z crossref_primary_10_3389_fgene_2021_625019 crossref_primary_10_3390_ncrna7020035 crossref_primary_10_1038_s41398_019_0448_z crossref_primary_10_1016_j_sleep_2023_11_014 crossref_primary_10_1007_s12672_025_02092_3 crossref_primary_10_1007_s00262_021_02937_0 crossref_primary_10_1016_j_biopha_2019_108655 crossref_primary_10_1089_dna_2018_4420 crossref_primary_10_1186_s13578_019_0345_4 crossref_primary_10_1016_j_mce_2020_111064 |
| ContentType | Journal Article |
| DBID | NPM 7X8 |
| DOI | 10.18632/oncotarget.24307 |
| DatabaseName | PubMed MEDLINE - Academic |
| DatabaseTitle | PubMed MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic PubMed |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | no_fulltext_linktorsrc |
| EISSN | 1949-2553 |
| ExternalDocumentID | 29719633 |
| Genre | Journal Article Review |
| GroupedDBID | --- 53G ADBBV ADRAZ AENEX ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL DIK FRJ GX1 HYE KQ8 M48 M~E NPM OK1 PGMZT RPM 7X8 |
| ID | FETCH-LOGICAL-c3147-af440ce3a892fa294f021d1c77df4a45ff4262bb14444405fb959261d716b0bd2 |
| IEDL.DBID | 7X8 |
| ISSN | 1949-2553 |
| IngestDate | Thu Jul 10 23:34:51 EDT 2025 Wed Feb 19 02:42:07 EST 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | false |
| IsScholarly | true |
| Issue | 26 |
| Keywords | cancer long non-coding RNA CNS disorder therapy |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c3147-af440ce3a892fa294f021d1c77df4a45ff4262bb14444405fb959261d716b0bd2 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 |
| OpenAccessLink | https://pubmed.ncbi.nlm.nih.gov/PMC5915100 |
| PMID | 29719633 |
| PQID | 2034293771 |
| PQPubID | 23479 |
| ParticipantIDs | proquest_miscellaneous_2034293771 pubmed_primary_29719633 |
| PublicationCentury | 2000 |
| PublicationDate | 2018-Apr-06 |
| PublicationDateYYYYMMDD | 2018-04-06 |
| PublicationDate_xml | – month: 04 year: 2018 text: 2018-Apr-06 day: 06 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Oncotarget |
| PublicationTitleAlternate | Oncotarget |
| PublicationYear | 2018 |
| References | 23776533 - PLoS One. 2013 Jun 11;8(6):e65711 21151960 - PLoS Genet. 2010 Dec 02;6(12):e1001233 2197983 - Annu Rev Biochem. 1990;59:543-68 14527995 - Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12247-52 27666543 - Nat Commun. 2016 Sep 26;7:12791 26975529 - Nat Commun. 2016 Mar 15;7:10982 17553964 - Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10679-84 23756188 - Brain Res Bull. 2013 Aug;97:69-80 27276568 - N Engl J Med. 2016 Jun 9;374(23):2287-9 26816378 - Science. 2016 Jan 15;351(6270):271-5 26142536 - Biochim Biophys Acta. 2016 Jan;1859(1):184-91 25640239 - Cell. 2015 Feb 12;160(4):595-606 23771028 - Hum Mol Genet. 2013 Nov 1;22(21):4318-28 25619660 - Neurobiol Aging. 2015 Mar;36(3):1601.e7-16 16286533 - Obes Res. 2005 Oct;13(10):1841-2 26191476 - Springerplus. 2015 Jul 16;4:349 25419621 - Viruses. 2014 Nov 20;6(11):4505-35 27514530 - J Exp Clin Cancer Res. 2016 Aug 11;35(1):125 27606977 - Pigment Cell Melanoma Res. 2016 Nov;29(6):619-626 17510325 - Science. 2007 Jun 8;316(5830):1484-8 28241429 - Int J Mol Sci. 2017 Feb 22;18(2) 2859520 - Mol Cell Biol. 1985 Mar;5(3):493-500 26977388 - Mol Metab. 2015 Dec 29;5(3):164-70 27694840 - Nat Struct Mol Biol. 2016 Nov;23 (11):1011-1019 29158793 - J Cancer. 2017 Sep 15;8(16):3212-3225 23028363 - PLoS Genet. 2012 Sep;8(9):e1002956 27250026 - Oncotarget. 2016 Jun 28;7(26):40418-40436 28024296 - Nature. 2017 Jan 12;541(7636):228-232 25149110 - J Mol Cell Cardiol. 2014 Nov;76:55-70 24651478 - PLoS Comput Biol. 2014 Mar 20;10(3):e1003517 22081608 - J Biol Chem. 2011 Dec 30;286(52):45093-102 22202438 - Neurobiol Dis. 2012 May;46(2):245-54 26578685 - FASEB J. 2016 Mar;30(3):1187-97 2722860 - J Biol Chem. 1989 Jun 15;264(17):10057-64 3899100 - Biochem J. 1985 Jul 1;229(1):1-17 27618650 - Nat Med. 2016 Oct;22(10 ):1131-1139 24005575 - Hum Genet. 2014 Jan;133(1):59-67 17237763 - Nature. 2007 Feb 8;445(7128):666-70 28542387 - PLoS One. 2017 May 19;12 (5):e0177843 25846769 - Oncol Rep. 2015 Jun;33(6):3045-52 28418892 - Oncotarget. 2017 Jun 13;8(24):39859-39876 27816050 - Aging (Albany NY). 2016 Nov 3;8(11):2948-2960 16915236 - Nature. 2006 Sep 14;443(7108):167-72 23399020 - FEBS J. 2013 Apr;280(7):1709-16 27466303 - Ann Clin Lab Sci. 2016 Jul;46(4):418-24 7589512 - FEBS Lett. 1995 Oct 23;374(1):57-61 21171977 - Orphanet J Rare Dis. 2010 Dec 20;5:40 27362246 - Arch Iran Med. 2016 Jul;19(7):508-17 26586396 - Tumour Biol. 2016 Jan;37(1):163-75 27109570 - Pflugers Arch. 2016 Jun;468(6):1071-87 24890811 - Cancer Sci. 2014 Aug;105(8):951-5 16467349 - Hum Mol Genet. 2006 Mar 15;15(6):965-77 28635106 - CNS Neurosci Ther. 2017 Aug;23 (8):645-656 21785702 - Int J Alzheimers Dis. 2011;2011:929042 23354591 - Cancer Lett. 2013 Jun 10;333(2):213-21 28978995 - Nat Rev Rheumatol. 2017 Nov;13(11):657-669 24115003 - Bioessays. 2013 Dec;35(12):1093-100 27431376 - Oncol Rep. 2016 Sep;36(3):1207-18 22576688 - Int J Oncol. 2012 Jul;41(1):276-84 27618117 - Biomolecules. 2016 Sep 08;6(3) 23835777 - J Cardiovasc Transl Res. 2013 Dec;6(6):876-83 26318290 - Neurobiol Aging. 2015 Nov;36(11):2925-2931 22580042 - Biochim Biophys Acta. 2012 Jul;1823(7):1170-7 28102845 - Cell Death Dis. 2017 Jan 19;8(1):e2569 22996644 - Dis Model Mech. 2013 Mar;6(2):424-33 27659713 - Eur J Med Genet. 2016 Nov;59(11):584-589 23435381 - Nat Struct Mol Biol. 2013 Apr;20(4):440-6 24429688 - Circulation. 2014 Mar 4;129(9):1009-21 15972963 - Am J Pathol. 2005 Jul;167(1):175-91 25123267 - Tumour Biol. 2014 Nov;35(11):11435-42 20541999 - Mol Cell. 2010 Jun 11;38(5):662-74 28611183 - Sci Signal. 2017 Jun 13;10 (483):null 20843979 - Cold Spring Harb Perspect Biol. 2010 Oct;2(10):a003574 18501714 - FEBS Lett. 2008 Jun 11;582(13):1919-27 18957214 - Neuron. 2008 Oct 23;60(2):201-14 24373479 - Eur Urol. 2014 Jun;65(6):1140-51 26633036 - PLoS Genet. 2015 Dec 03;11(12):e1005680 18974356 - Science. 2008 Oct 31;322(5902):750-6 28138111 - Clin Psychopharmacol Neurosci. 2017 Feb 28;15(1):53-58 17604720 - Cell. 2007 Jun 29;129(7):1311-23 24275495 - Nucleic Acids Res. 2014 Jan;42(Database issue):D68-73 26701265 - Genes Dev. 2016 Jan 1;30(1):34-51 20068297 - Cytogenet Genome Res. 2009;126(3):259-70 16914571 - Clin Cancer Res. 2006 Aug 15;12(16):4851-8 27453777 - Transl Neurodegener. 2016 Jul 22;5:14 19182780 - Nature. 2009 Mar 12;458(7235):223-7 28540248 - Transl Androl Urol. 2017 Apr;6(2):326-330 27732939 - Oncotarget. 2017 Jan 17;8(3):5508-5522 11247792 - Am J Physiol Heart Circ Physiol. 2001 Apr;280(4):H1782-92 26138586 - Tumour Biol. 2015 Dec;36(12):9545-52 27546335 - J Neurochem. 2016 Oct;139 Suppl 1:216-231 16537902 - Mol Cell Biol. 2006 Apr;26(7):2560-9 24680897 - Int J Biochem Cell Biol. 2014 Sep;54:318-30 26322075 - Front Genet. 2015 Aug 10;6:263 20368139 - Hum Genomics. 2010 Feb;4(3):170-93 22959273 - Mol Cell. 2012 Oct 26;48(2):219-30 12162957 - J Mol Biol. 2002 Aug 16;321(3):433-45 23160002 - Nat Chem Biol. 2013 Jan;9(1):59-64 25829178 - Nucleic Acids Res. 2015 Apr 30;43(8):4363-4 24495014 - FEBS J. 2014 Apr;281(7):1750-8 17074884 - J Cell Biol. 2006 Nov 6;175(3):427-39 27248326 - Oncotarget. 2016 Jul 12;7(28):43256-43266 26880762 - J Immunol. 2016 Mar 15;196 (6):2799-2808 23064229 - Nature. 2012 Nov 15;491(7424):454-7 25883552 - Front Cell Neurosci. 2015 Apr 01;9:114 27221610 - Mol Neurobiol. 2017 Mar;54(2):1577-1586 27191888 - Oncotarget. 2016 Jun 21;7(25):37957-37965 26621851 - Oncotarget. 2016 Jan 19;7(3):3201-16 8636375 - J Clin Endocrinol Metab. 1996 Apr;81(4):1607-12 20307503 - Brain Res. 2010 Jun 18;1338:36-47 24648007 - Oncol Rep. 2014 May;31(5):1993-2000 24530304 - Mol Cell. 2014 Mar 20;53(6):1005-19 25432725 - Neurol Clin. 2015 Feb;33(1):101-14 21925379 - Mol Cell. 2011 Sep 16;43(6):904-14 12461786 - J Cell Biochem. 2003 Jan 1;88(1):165-80 22266873 - Oncogene. 2012 Oct 25;31(43):4577-87 24667321 - Biochim Biophys Acta. 2014 Oct;1842(10):1910-1922 25777523 - Bioinformatics. 2015 Jul 15;31(14):2241-51 18039709 - Nucleic Acids Res. 2008 Feb;36(2):423-34 24525122 - Biochem Biophys Res Commun. 2014 Mar 7;445(2):388-93 20179156 - Physiol Genomics. 2010 May;41(3):269-74 23102265 - Mol Cell. 2012 Oct 26;48(2):155-7 22955987 - Genome Res. 2012 Sep;22(9):1760-74 28376901 - Radiat Oncol. 2017 Apr 4;12 (1):65 22735187 - EMBO J. 2012 Jun 26;31(14):3038-62 21151178 - Oncogene. 2011 Apr 21;30(16):1956-62 27780933 - Oncotarget. 2016 Nov 15;7(46):74484-74495 21550244 - Trends Cell Biol. 2011 Jun;21(6):354-61 24703882 - Biochim Biophys Acta. 2014 Jul;1843(7):1414-26 15985428 - J Biol Chem. 2005 Aug 19;280(33):29625-36 23697773 - Circ Res. 2013 Jul 19;113(3):266-78 6197186 - Cell. 1983 Dec;35(3 Pt 2):849-57 18045242 - J Neurochem. 2008 Apr;105(2):351-9 8446635 - Proc Natl Acad Sci U S A. 1993 Mar 1;90(5):2092-6 23990798 - PLoS Genet. 2013;9(8):e1003705 27617288 - Sci Adv. 2016 Sep 02;2(9):e1600220 25033876 - BMC Syst Biol. 2014 Jul 17;8:83 25654223 - Int J Mol Sci. 2015 Feb 03;16(2):3251-66 25233276 - Elife. 2014 Sep 16;3:e03523 25560704 - Nat Rev Endocrinol. 2015 Mar;11(3):151-60 25119045 - Nature. 2014 Oct 2;514(7520):102-106 7855987 - Urology. 1995 Feb;45(2):335-8 27586866 - Sci Rep. 2016 Sep 02;6:30798 20956613 - FASEB J. 2011 Feb;25(2):444-8 26788991 - Oncotarget. 2016 Feb 23;7(8):8601-12 22034492 - Circ Res. 2011 Dec 9;109(12):1332-41 22408643 - Front Genet. 2012 Mar 08;3:32 7849716 - Hum Mol Genet. 1994 Oct;3(10):1877-82 28616363 - Curr Pathobiol Rep. 2017 Mar;5(1):23-34 27460088 - Tumour Biol. 2016 Oct;37(10 ):13385-13390 26979073 - Curr Neurovasc Res. 2016;13(2):115-20 18587408 - Nat Med. 2008 Jul;14(7):723-30 20888417 - Neurobiol Dis. 2011 Feb;41(2):308-17 17970741 - Eur J Neurosci. 2007 Nov;26(9):2444-57 28796922 - Cancer Sci. 2017 Nov;108(11):2107-2114 26471251 - Sci Rep. 2015 Oct 16;5:15184 17362513 - BMC Genomics. 2007 Mar 15;8:74 |
| References_xml | – reference: 23435381 - Nat Struct Mol Biol. 2013 Apr;20(4):440-6 – reference: 16915236 - Nature. 2006 Sep 14;443(7108):167-72 – reference: 23354591 - Cancer Lett. 2013 Jun 10;333(2):213-21 – reference: 26979073 - Curr Neurovasc Res. 2016;13(2):115-20 – reference: 23990798 - PLoS Genet. 2013;9(8):e1003705 – reference: 28796922 - Cancer Sci. 2017 Nov;108(11):2107-2114 – reference: 26578685 - FASEB J. 2016 Mar;30(3):1187-97 – reference: 27618117 - Biomolecules. 2016 Sep 08;6(3): – reference: 26142536 - Biochim Biophys Acta. 2016 Jan;1859(1):184-91 – reference: 22959273 - Mol Cell. 2012 Oct 26;48(2):219-30 – reference: 26191476 - Springerplus. 2015 Jul 16;4:349 – reference: 8446635 - Proc Natl Acad Sci U S A. 1993 Mar 1;90(5):2092-6 – reference: 27362246 - Arch Iran Med. 2016 Jul;19(7):508-17 – reference: 14527995 - Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12247-52 – reference: 27191888 - Oncotarget. 2016 Jun 21;7(25):37957-37965 – reference: 20368139 - Hum Genomics. 2010 Feb;4(3):170-93 – reference: 22580042 - Biochim Biophys Acta. 2012 Jul;1823(7):1170-7 – reference: 27431376 - Oncol Rep. 2016 Sep;36(3):1207-18 – reference: 11247792 - Am J Physiol Heart Circ Physiol. 2001 Apr;280(4):H1782-92 – reference: 23399020 - FEBS J. 2013 Apr;280(7):1709-16 – reference: 20307503 - Brain Res. 2010 Jun 18;1338:36-47 – reference: 15972963 - Am J Pathol. 2005 Jul;167(1):175-91 – reference: 23776533 - PLoS One. 2013 Jun 11;8(6):e65711 – reference: 26880762 - J Immunol. 2016 Mar 15;196 (6):2799-2808 – reference: 12162957 - J Mol Biol. 2002 Aug 16;321(3):433-45 – reference: 21785702 - Int J Alzheimers Dis. 2011;2011:929042 – reference: 24680897 - Int J Biochem Cell Biol. 2014 Sep;54:318-30 – reference: 26975529 - Nat Commun. 2016 Mar 15;7:10982 – reference: 17604720 - Cell. 2007 Jun 29;129(7):1311-23 – reference: 18501714 - FEBS Lett. 2008 Jun 11;582(13):1919-27 – reference: 24703882 - Biochim Biophys Acta. 2014 Jul;1843(7):1414-26 – reference: 27694840 - Nat Struct Mol Biol. 2016 Nov;23 (11):1011-1019 – reference: 18039709 - Nucleic Acids Res. 2008 Feb;36(2):423-34 – reference: 25432725 - Neurol Clin. 2015 Feb;33(1):101-14 – reference: 24275495 - Nucleic Acids Res. 2014 Jan;42(Database issue):D68-73 – reference: 17237763 - Nature. 2007 Feb 8;445(7128):666-70 – reference: 27460088 - Tumour Biol. 2016 Oct;37(10 ):13385-13390 – reference: 20541999 - Mol Cell. 2010 Jun 11;38(5):662-74 – reference: 21151178 - Oncogene. 2011 Apr 21;30(16):1956-62 – reference: 24530304 - Mol Cell. 2014 Mar 20;53(6):1005-19 – reference: 26977388 - Mol Metab. 2015 Dec 29;5(3):164-70 – reference: 27276568 - N Engl J Med. 2016 Jun 9;374(23):2287-9 – reference: 22202438 - Neurobiol Dis. 2012 May;46(2):245-54 – reference: 25233276 - Elife. 2014 Sep 16;3:e03523 – reference: 28611183 - Sci Signal. 2017 Jun 13;10 (483):null – reference: 22735187 - EMBO J. 2012 Jun 26;31(14):3038-62 – reference: 24429688 - Circulation. 2014 Mar 4;129(9):1009-21 – reference: 28138111 - Clin Psychopharmacol Neurosci. 2017 Feb 28;15(1):53-58 – reference: 28241429 - Int J Mol Sci. 2017 Feb 22;18(2): – reference: 12461786 - J Cell Biochem. 2003 Jan 1;88(1):165-80 – reference: 17362513 - BMC Genomics. 2007 Mar 15;8:74 – reference: 23771028 - Hum Mol Genet. 2013 Nov 1;22(21):4318-28 – reference: 2197983 - Annu Rev Biochem. 1990;59:543-68 – reference: 24373479 - Eur Urol. 2014 Jun;65(6):1140-51 – reference: 16286533 - Obes Res. 2005 Oct;13(10):1841-2 – reference: 25419621 - Viruses. 2014 Nov 20;6(11):4505-35 – reference: 27221610 - Mol Neurobiol. 2017 Mar;54(2):1577-1586 – reference: 28978995 - Nat Rev Rheumatol. 2017 Nov;13(11):657-669 – reference: 27659713 - Eur J Med Genet. 2016 Nov;59(11):584-589 – reference: 20068297 - Cytogenet Genome Res. 2009;126(3):259-70 – reference: 28616363 - Curr Pathobiol Rep. 2017 Mar;5(1):23-34 – reference: 27606977 - Pigment Cell Melanoma Res. 2016 Nov;29(6):619-626 – reference: 23028363 - PLoS Genet. 2012 Sep;8(9):e1002956 – reference: 22576688 - Int J Oncol. 2012 Jul;41(1):276-84 – reference: 22996644 - Dis Model Mech. 2013 Mar;6(2):424-33 – reference: 26586396 - Tumour Biol. 2016 Jan;37(1):163-75 – reference: 27732939 - Oncotarget. 2017 Jan 17;8(3):5508-5522 – reference: 21171977 - Orphanet J Rare Dis. 2010 Dec 20;5:40 – reference: 23835777 - J Cardiovasc Transl Res. 2013 Dec;6(6):876-83 – reference: 24667321 - Biochim Biophys Acta. 2014 Oct;1842(10):1910-1922 – reference: 22081608 - J Biol Chem. 2011 Dec 30;286(52):45093-102 – reference: 26633036 - PLoS Genet. 2015 Dec 03;11(12):e1005680 – reference: 3899100 - Biochem J. 1985 Jul 1;229(1):1-17 – reference: 17970741 - Eur J Neurosci. 2007 Nov;26(9):2444-57 – reference: 25883552 - Front Cell Neurosci. 2015 Apr 01;9:114 – reference: 28102845 - Cell Death Dis. 2017 Jan 19;8(1):e2569 – reference: 26471251 - Sci Rep. 2015 Oct 16;5:15184 – reference: 27453777 - Transl Neurodegener. 2016 Jul 22;5:14 – reference: 24525122 - Biochem Biophys Res Commun. 2014 Mar 7;445(2):388-93 – reference: 2859520 - Mol Cell Biol. 1985 Mar;5(3):493-500 – reference: 19182780 - Nature. 2009 Mar 12;458(7235):223-7 – reference: 22034492 - Circ Res. 2011 Dec 9;109(12):1332-41 – reference: 26138586 - Tumour Biol. 2015 Dec;36(12):9545-52 – reference: 21151960 - PLoS Genet. 2010 Dec 02;6(12):e1001233 – reference: 24648007 - Oncol Rep. 2014 May;31(5):1993-2000 – reference: 16467349 - Hum Mol Genet. 2006 Mar 15;15(6):965-77 – reference: 20956613 - FASEB J. 2011 Feb;25(2):444-8 – reference: 25640239 - Cell. 2015 Feb 12;160(4):595-606 – reference: 26788991 - Oncotarget. 2016 Feb 23;7(8):8601-12 – reference: 27250026 - Oncotarget. 2016 Jun 28;7(26):40418-40436 – reference: 18974356 - Science. 2008 Oct 31;322(5902):750-6 – reference: 6197186 - Cell. 1983 Dec;35(3 Pt 2):849-57 – reference: 24890811 - Cancer Sci. 2014 Aug;105(8):951-5 – reference: 2722860 - J Biol Chem. 1989 Jun 15;264(17):10057-64 – reference: 25846769 - Oncol Rep. 2015 Jun;33(6):3045-52 – reference: 7589512 - FEBS Lett. 1995 Oct 23;374(1):57-61 – reference: 25119045 - Nature. 2014 Oct 2;514(7520):102-106 – reference: 24115003 - Bioessays. 2013 Dec;35(12):1093-100 – reference: 27617288 - Sci Adv. 2016 Sep 02;2(9):e1600220 – reference: 26322075 - Front Genet. 2015 Aug 10;6:263 – reference: 18045242 - J Neurochem. 2008 Apr;105(2):351-9 – reference: 28635106 - CNS Neurosci Ther. 2017 Aug;23 (8):645-656 – reference: 27466303 - Ann Clin Lab Sci. 2016 Jul;46(4):418-24 – reference: 18587408 - Nat Med. 2008 Jul;14(7):723-30 – reference: 29158793 - J Cancer. 2017 Sep 15;8(16):3212-3225 – reference: 20888417 - Neurobiol Dis. 2011 Feb;41(2):308-17 – reference: 27109570 - Pflugers Arch. 2016 Jun;468(6):1071-87 – reference: 17510325 - Science. 2007 Jun 8;316(5830):1484-8 – reference: 7855987 - Urology. 1995 Feb;45(2):335-8 – reference: 26816378 - Science. 2016 Jan 15;351(6270):271-5 – reference: 20843979 - Cold Spring Harb Perspect Biol. 2010 Oct;2(10):a003574 – reference: 25123267 - Tumour Biol. 2014 Nov;35(11):11435-42 – reference: 15985428 - J Biol Chem. 2005 Aug 19;280(33):29625-36 – reference: 23697773 - Circ Res. 2013 Jul 19;113(3):266-78 – reference: 22266873 - Oncogene. 2012 Oct 25;31(43):4577-87 – reference: 25560704 - Nat Rev Endocrinol. 2015 Mar;11(3):151-60 – reference: 17074884 - J Cell Biol. 2006 Nov 6;175(3):427-39 – reference: 27514530 - J Exp Clin Cancer Res. 2016 Aug 11;35(1):125 – reference: 25033876 - BMC Syst Biol. 2014 Jul 17;8:83 – reference: 28418892 - Oncotarget. 2017 Jun 13;8(24):39859-39876 – reference: 16914571 - Clin Cancer Res. 2006 Aug 15;12(16):4851-8 – reference: 24005575 - Hum Genet. 2014 Jan;133(1):59-67 – reference: 26701265 - Genes Dev. 2016 Jan 1;30(1):34-51 – reference: 24495014 - FEBS J. 2014 Apr;281(7):1750-8 – reference: 25149110 - J Mol Cell Cardiol. 2014 Nov;76:55-70 – reference: 23102265 - Mol Cell. 2012 Oct 26;48(2):155-7 – reference: 7849716 - Hum Mol Genet. 1994 Oct;3(10):1877-82 – reference: 8636375 - J Clin Endocrinol Metab. 1996 Apr;81(4):1607-12 – reference: 24651478 - PLoS Comput Biol. 2014 Mar 20;10(3):e1003517 – reference: 27816050 - Aging (Albany NY). 2016 Nov 3;8(11):2948-2960 – reference: 18957214 - Neuron. 2008 Oct 23;60(2):201-14 – reference: 28540248 - Transl Androl Urol. 2017 Apr;6(2):326-330 – reference: 27586866 - Sci Rep. 2016 Sep 02;6:30798 – reference: 27546335 - J Neurochem. 2016 Oct;139 Suppl 1:216-231 – reference: 23064229 - Nature. 2012 Nov 15;491(7424):454-7 – reference: 23160002 - Nat Chem Biol. 2013 Jan;9(1):59-64 – reference: 27780933 - Oncotarget. 2016 Nov 15;7(46):74484-74495 – reference: 21925379 - Mol Cell. 2011 Sep 16;43(6):904-14 – reference: 21550244 - Trends Cell Biol. 2011 Jun;21(6):354-61 – reference: 26621851 - Oncotarget. 2016 Jan 19;7(3):3201-16 – reference: 20179156 - Physiol Genomics. 2010 May;41(3):269-74 – reference: 27248326 - Oncotarget. 2016 Jul 12;7(28):43256-43266 – reference: 16537902 - Mol Cell Biol. 2006 Apr;26(7):2560-9 – reference: 25829178 - Nucleic Acids Res. 2015 Apr 30;43(8):4363-4 – reference: 26318290 - Neurobiol Aging. 2015 Nov;36(11):2925-2931 – reference: 25619660 - Neurobiol Aging. 2015 Mar;36(3):1601.e7-16 – reference: 28024296 - Nature. 2017 Jan 12;541(7636):228-232 – reference: 28376901 - Radiat Oncol. 2017 Apr 4;12 (1):65 – reference: 22408643 - Front Genet. 2012 Mar 08;3:32 – reference: 17553964 - Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10679-84 – reference: 25777523 - Bioinformatics. 2015 Jul 15;31(14):2241-51 – reference: 22955987 - Genome Res. 2012 Sep;22(9):1760-74 – reference: 27666543 - Nat Commun. 2016 Sep 26;7:12791 – reference: 23756188 - Brain Res Bull. 2013 Aug;97:69-80 – reference: 28542387 - PLoS One. 2017 May 19;12 (5):e0177843 – reference: 25654223 - Int J Mol Sci. 2015 Feb 03;16(2):3251-66 – reference: 27618650 - Nat Med. 2016 Oct;22(10 ):1131-1139 |
| SSID | ssj0000547829 |
| Score | 2.5557802 |
| SecondaryResourceType | review_article |
| Snippet | LncRNAs are long non-coding regulatory RNAs that are longer than 200 nucleotides. One of the major functions of lncRNAs is the regulation of specific gene... |
| SourceID | proquest pubmed |
| SourceType | Aggregation Database Index Database |
| StartPage | 18648 |
| Title | Molecular mechanisms of long noncoding RNAs and their role in disease pathogenesis |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/29719633 https://www.proquest.com/docview/2034293771 |
| Volume | 9 |
| hasFullText | |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LS8QwEA7qevDiA1_riwheo22SbZKTLOLiZcuyKOyt5NEsBW1Xq_5-J9mungTBHnIrDMNkZr6ZyXwIXXHlfJYJRyylinBHPVGGM2JcQo3NjNPOR7IJkedyNlOTruDWdmOVK58YHbVrbKiRA0hn4DqZEOnt4pUE1qjQXe0oNNZRj0EqE6xazOR3jSUJy6oiURlAdUUge2ZdY1NmjN40Yf1BnLe-ppwl4vckMwab0c5_xdxF212aiYdLu9hDa2W9j6bjFRcufinDi9-qfWlx4_FzU89xHQQNkQxP82GLde1w7CLgMICIqxp3vRwcSIybefCRVXuAnkb3j3cPpONUIJalXBDtOU9sybRU1GuquIcg71IrhPNc84H3YUW9MYCz4EsG3qiBApTlAFeZxDh6iDZAnvIYYWFsopW0EiAWtzyR2lKvWCZTYaQzaR9drlRUgM2GRoSuy-ajLX6U1EdHSz0Xi-VyjYIqEZwCO_nD36doC_IXGQdpsjPU83Bjy3O0aT_fq_btIhoDnPlk_AVXb7_o |
| linkProvider | ProQuest |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Molecular+mechanisms+of+long+noncoding+RNAs+and+their+role+in+disease+pathogenesis&rft.jtitle=Oncotarget&rft.au=Hu%2C+Guoku&rft.au=Niu%2C+Fang&rft.au=Humburg%2C+Bree+A&rft.au=Liao%2C+Ke&rft.date=2018-04-06&rft.eissn=1949-2553&rft.volume=9&rft.issue=26&rft.spage=18648&rft_id=info:doi/10.18632%2Foncotarget.24307&rft_id=info%3Apmid%2F29719633&rft_id=info%3Apmid%2F29719633&rft.externalDocID=29719633 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1949-2553&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1949-2553&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1949-2553&client=summon |