Ferroptosis induction, androgen biosynthesis disruption and prostate cancer suppression by androgen and vitamin D combination

Prostate cancer regression by hormonal vitamin D3(calcitriol) is clinically untenable despite its well-documented anticancer effects in experimental models, since supraphysiologic dosing of calcitriol required in clinical settings causes hypercalcemia and other toxicities. We show that subnanomolar/...

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Veröffentlicht in:	Biochimica et biophysica acta. General subjects Jg. 1869; H. 8; S. 130828
Hauptverfasser:	Park, Bobae, Khadka, Subash, Ahn, Jungmi, Vaquiz, Jacqueline, Igbekoyi, Okunola, Song, Chung S., Chatterjee, Bandana
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Netherlands Elsevier B.V 01.07.2025
Schlagworte:	Androgen Androgen inactivation Androgens - biosynthesis Androgens - pharmacology Animals Calcitriol - pharmacology Cell Line, Tumor Cell Proliferation - drug effects Combination treatment Ferritinophagy Ferroptosis - drug effects Humans Lipid peroxidation Male Mice Mice, Nude Prostate cancer Prostatic Neoplasms - drug therapy Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Vitamin D Vitamin D - pharmacology Xenograft Model Antitumor Assays DHEA Combination treatment Ferritinophagy ALOX-5 LC3B AKR1D1 Lipid peroxidation MDA PTGS2 CYP17A1 Vitamin D 5α-DHT RNA-seq GSH FTH-1 Androgen MLKL NCOA4 AKR1C3 AKR1C2 GPX 4 PARP-1 D3 AR CYP24A1 HSD3β1 Androgen inactivation Δ4-AED Prostate cancer CRPC
ISSN:	0304-4165, 1872-8006, 1872-8006
Online-Zugang:	Volltext
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