Multiple Positive Sweat Chloride Tests in an Infant Asymptomatic for Cystic Fibrosis

[...]one study reported that the percentage of infants diagnosed with CF increased with increasing IRT values (CF diagnosed in 1.6% of infants with IRT values <100 ng/mL, and in 48% of infants with IRT values >150 ng/mL).14 However, circulating trypsinogen levels cannot be used as a screening...

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Bibliographic Details
Published in:Laboratory medicine Vol. 43; no. 2; pp. 1 - 5
Main Authors: Cotten, Steven W., Bender, Laura M., Willis, Monte S.
Format: Journal Article
Language:English
Published: Chicago Oxford University Press 01.02.2012
Subjects:
Antibiotics
Cystic fibrosis
Diabetes
Fluorides
Hypothyroidism
Medical screening
Mutation
Newborn babies
Pancreas
ISSN:0007-5027, 1943-7730
Online Access:Get full text
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Summary:[...]one study reported that the percentage of infants diagnosed with CF increased with increasing IRT values (CF diagnosed in 1.6% of infants with IRT values <100 ng/mL, and in 48% of infants with IRT values >150 ng/mL).14 However, circulating trypsinogen levels cannot be used as a screening test for CF in all age groups. Positive cultures or acquisition of Pseudomonas aeruginosa infection should be treated with anti-pseudomonal antibiotics and increased airway clearance even in the absence of symptoms.25 For evaluation of pulmonary function, the CF foundation recommends a baseline chest x-ray be obtained within the first 3-6 months of life and once again within the first 2 years of life in the presence or absence of symptoms.25 Patient Follow-Up and Treatment In addition to salt supplementation, the patient was started on a regimen of CF multivitamins and pancreatic enzyme supplementation (one-half capsule with feedings).
Bibliography:SourceType-Scholarly Journals-1
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ISSN:0007-5027
1943-7730
DOI:10.1309/LM19FQYQEFOWUT9X