Multiple Positive Sweat Chloride Tests in an Infant Asymptomatic for Cystic Fibrosis

[...]one study reported that the percentage of infants diagnosed with CF increased with increasing IRT values (CF diagnosed in 1.6% of infants with IRT values <100 ng/mL, and in 48% of infants with IRT values >150 ng/mL).14 However, circulating trypsinogen levels cannot be used as a screening...

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Vydané v:Laboratory medicine Ročník 43; číslo 2; s. 1 - 5
Hlavní autori: Cotten, Steven W., Bender, Laura M., Willis, Monte S.
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Chicago Oxford University Press 01.02.2012
Predmet:
Antibiotics
Cystic fibrosis
Diabetes
Fluorides
Hypothyroidism
Medical screening
Mutation
Newborn babies
Pancreas
ISSN:0007-5027, 1943-7730
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Shrnutí:[...]one study reported that the percentage of infants diagnosed with CF increased with increasing IRT values (CF diagnosed in 1.6% of infants with IRT values <100 ng/mL, and in 48% of infants with IRT values >150 ng/mL).14 However, circulating trypsinogen levels cannot be used as a screening test for CF in all age groups. Positive cultures or acquisition of Pseudomonas aeruginosa infection should be treated with anti-pseudomonal antibiotics and increased airway clearance even in the absence of symptoms.25 For evaluation of pulmonary function, the CF foundation recommends a baseline chest x-ray be obtained within the first 3-6 months of life and once again within the first 2 years of life in the presence or absence of symptoms.25 Patient Follow-Up and Treatment In addition to salt supplementation, the patient was started on a regimen of CF multivitamins and pancreatic enzyme supplementation (one-half capsule with feedings).
Bibliografia:SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 14
ISSN:0007-5027
1943-7730
DOI:10.1309/LM19FQYQEFOWUT9X