Development of a one-step centrifugal extraction method for simultaneous determination of multiple types of pesticides and their metabolites in urine, serum, and breast milk

•A one-step centrifugal-assisted CIPS method was developed in biological samples.•Centrifugal-assisted technique enhances performance in sample preparation.•Multiplexed tSIM method was used for highly sensitive and accurate quantification.•The greenness profile and practicality of this method were a...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of Chromatography A Vol. 1763; p. 466432
Main Authors:	Zhang, Chi, Zhan, Zhipeng, Li, Jingguang, Wu, Yongning, Chen, Dawei, Li, Hong
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 22.11.2025
Subjects:	Advanced instrumental analysis Biomonitoring Centrifugation - methods Centrifuge Chromatography, Liquid - methods Female Humans Limit of Detection Linear Models Milk, Human - chemistry Multiplexed method Pesticide Residues - analysis Pesticide Residues - blood Pesticide Residues - isolation & purification Pesticide Residues - urine Pesticides - analysis Pesticides - blood Pesticides - isolation & purification Pesticides - metabolism Pesticides - urine Reproducibility of Results Sample preparation Centrifuge Biomonitoring Advanced instrumental analysis Sample preparation Multiplexed method
ISSN:	0021-9673, 1873-3778, 1873-3778
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Abstract	•A one-step centrifugal-assisted CIPS method was developed in biological samples.•Centrifugal-assisted technique enhances performance in sample preparation.•Multiplexed tSIM method was used for highly sensitive and accurate quantification.•The greenness profile and practicality of this method were assessed. An efficient and highly sensitive analytical method was developed for the simultaneous determination of neonicotinoids, benzopyrazoles, diamide insecticides and chlorothalonil fungicide and their metabolites in biological samples (urine, serum and breast milk). The method combines centrifugal-assisted cold-induced phase separation (CIPS) with liquid chromatography and high-resolution mass spectrometry (LCHRMS) in multiplexed-targeted single-ion monitoring (MSX-tSIM) mode to ensure high sensitivity and accuracy. Sample preparation parameters such as solvent selection and acetonitrile/water ratio were optimized to improve analyte recovery and minimize matrix effects. The method exhibited excellent accuracy, precision, and low limit of quantification (LLOQ) in the range of 0.01–0.2 µg/L, with recoveries ranging from 72.6 % to 109.6 % in a variety of biological matrices. The method showed good linearity (R² > 0.993) and was suitable for the detection of trace pesticide levels in complex biological samples. Biomonitoring of pooled samples revealed widespread neonicotinoids contamination, with fipronil metabolites detected only in serum and breast milk, raising concerns about the potential accumulation of pesticide metabolites in the human body, especially in susceptible populations. This method provides a cost-effective and environmentally friendly alternative to traditional methods, facilitates large-scale human biomonitoring studies, and supports pesticide exposure risk assessment.
AbstractList	An efficient and highly sensitive analytical method was developed for the simultaneous determination of neonicotinoids, benzopyrazoles, diamide insecticides and chlorothalonil fungicide and their metabolites in biological samples (urine, serum and breast milk). The method combines centrifugal-assisted cold-induced phase separation (CIPS) with liquid chromatography and high-resolution mass spectrometry (LCHRMS) in multiplexed-targeted single-ion monitoring (MSX-tSIM) mode to ensure high sensitivity and accuracy. Sample preparation parameters such as solvent selection and acetonitrile/water ratio were optimized to improve analyte recovery and minimize matrix effects. The method exhibited excellent accuracy, precision, and low limit of quantification (LLOQ) in the range of 0.01-0.2 µg/L, with recoveries ranging from 72.6 % to 109.6 % in a variety of biological matrices. The method showed good linearity (R² > 0.993) and was suitable for the detection of trace pesticide levels in complex biological samples. Biomonitoring of pooled samples revealed widespread neonicotinoids contamination, with fipronil metabolites detected only in serum and breast milk, raising concerns about the potential accumulation of pesticide metabolites in the human body, especially in susceptible populations. This method provides a cost-effective and environmentally friendly alternative to traditional methods, facilitates large-scale human biomonitoring studies, and supports pesticide exposure risk assessment.An efficient and highly sensitive analytical method was developed for the simultaneous determination of neonicotinoids, benzopyrazoles, diamide insecticides and chlorothalonil fungicide and their metabolites in biological samples (urine, serum and breast milk). The method combines centrifugal-assisted cold-induced phase separation (CIPS) with liquid chromatography and high-resolution mass spectrometry (LCHRMS) in multiplexed-targeted single-ion monitoring (MSX-tSIM) mode to ensure high sensitivity and accuracy. Sample preparation parameters such as solvent selection and acetonitrile/water ratio were optimized to improve analyte recovery and minimize matrix effects. The method exhibited excellent accuracy, precision, and low limit of quantification (LLOQ) in the range of 0.01-0.2 µg/L, with recoveries ranging from 72.6 % to 109.6 % in a variety of biological matrices. The method showed good linearity (R² > 0.993) and was suitable for the detection of trace pesticide levels in complex biological samples. Biomonitoring of pooled samples revealed widespread neonicotinoids contamination, with fipronil metabolites detected only in serum and breast milk, raising concerns about the potential accumulation of pesticide metabolites in the human body, especially in susceptible populations. This method provides a cost-effective and environmentally friendly alternative to traditional methods, facilitates large-scale human biomonitoring studies, and supports pesticide exposure risk assessment. •A one-step centrifugal-assisted CIPS method was developed in biological samples.•Centrifugal-assisted technique enhances performance in sample preparation.•Multiplexed tSIM method was used for highly sensitive and accurate quantification.•The greenness profile and practicality of this method were assessed. An efficient and highly sensitive analytical method was developed for the simultaneous determination of neonicotinoids, benzopyrazoles, diamide insecticides and chlorothalonil fungicide and their metabolites in biological samples (urine, serum and breast milk). The method combines centrifugal-assisted cold-induced phase separation (CIPS) with liquid chromatography and high-resolution mass spectrometry (LCHRMS) in multiplexed-targeted single-ion monitoring (MSX-tSIM) mode to ensure high sensitivity and accuracy. Sample preparation parameters such as solvent selection and acetonitrile/water ratio were optimized to improve analyte recovery and minimize matrix effects. The method exhibited excellent accuracy, precision, and low limit of quantification (LLOQ) in the range of 0.01–0.2 µg/L, with recoveries ranging from 72.6 % to 109.6 % in a variety of biological matrices. The method showed good linearity (R² > 0.993) and was suitable for the detection of trace pesticide levels in complex biological samples. Biomonitoring of pooled samples revealed widespread neonicotinoids contamination, with fipronil metabolites detected only in serum and breast milk, raising concerns about the potential accumulation of pesticide metabolites in the human body, especially in susceptible populations. This method provides a cost-effective and environmentally friendly alternative to traditional methods, facilitates large-scale human biomonitoring studies, and supports pesticide exposure risk assessment. An efficient and highly sensitive analytical method was developed for the simultaneous determination of neonicotinoids, benzopyrazoles, diamide insecticides and chlorothalonil fungicide and their metabolites in biological samples (urine, serum and breast milk). The method combines centrifugal-assisted cold-induced phase separation (CIPS) with liquid chromatography and high-resolution mass spectrometry (LCHRMS) in multiplexed-targeted single-ion monitoring (MSX-tSIM) mode to ensure high sensitivity and accuracy. Sample preparation parameters such as solvent selection and acetonitrile/water ratio were optimized to improve analyte recovery and minimize matrix effects. The method exhibited excellent accuracy, precision, and low limit of quantification (LLOQ) in the range of 0.01-0.2 µg/L, with recoveries ranging from 72.6 % to 109.6 % in a variety of biological matrices. The method showed good linearity (R² > 0.993) and was suitable for the detection of trace pesticide levels in complex biological samples. Biomonitoring of pooled samples revealed widespread neonicotinoids contamination, with fipronil metabolites detected only in serum and breast milk, raising concerns about the potential accumulation of pesticide metabolites in the human body, especially in susceptible populations. This method provides a cost-effective and environmentally friendly alternative to traditional methods, facilitates large-scale human biomonitoring studies, and supports pesticide exposure risk assessment.
ArticleNumber	466432
Author	Zhang, Chi Li, Hong Zhan, Zhipeng Li, Jingguang Wu, Yongning Chen, Dawei
Author_xml	– sequence: 1 givenname: Chi surname: Zhang fullname: Zhang, Chi organization: NHC Key Laboratory of Food Safety Risk Assessment, Chinese Academy of Medical Science Research Unit (No. 2019RU014), China National Center for Food Safety Risk Assessment, Beijing 100021, China – sequence: 2 givenname: Zhipeng surname: Zhan fullname: Zhan, Zhipeng email: zhanzhipeng@jzmu.edu.cn organization: School of Public Health, Jinzhou Medical University, Jinzhou 121001, China – sequence: 3 givenname: Jingguang surname: Li fullname: Li, Jingguang email: lijg@cfsa.net.cn organization: NHC Key Laboratory of Food Safety Risk Assessment, Chinese Academy of Medical Science Research Unit (No. 2019RU014), China National Center for Food Safety Risk Assessment, Beijing 100021, China – sequence: 4 givenname: Yongning surname: Wu fullname: Wu, Yongning email: wuyongning@cfsa.ent.cn organization: NHC Key Laboratory of Food Safety Risk Assessment, Chinese Academy of Medical Science Research Unit (No. 2019RU014), China National Center for Food Safety Risk Assessment, Beijing 100021, China – sequence: 5 givenname: Dawei orcidid: 0000-0002-4015-2557 surname: Chen fullname: Chen, Dawei email: chendw@cfsa.net.cn organization: NHC Key Laboratory of Food Safety Risk Assessment, Chinese Academy of Medical Science Research Unit (No. 2019RU014), China National Center for Food Safety Risk Assessment, Beijing 100021, China – sequence: 6 givenname: Hong surname: Li fullname: Li, Hong email: lih@jzmu.edu.cn organization: School of Public Health, Jinzhou Medical University, Jinzhou 121001, China
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/41061598$$D View this record in MEDLINE/PubMed
BookMark	eNp9kc1u3SAQhVGVqrlJ-wZVxbKL-BaMbexNpSr9ixQpm3SNMAy93BpwAUfJQ-Udi-O0y65GDN8cmHPO0IkPHhB6S8meEtp9OO7VIQYn9zWp233TdQ2rX6Ad7TmrGOf9CdoRUtNq6Dg7RWcpHQmhnPD6FTptKOloO_Q79PgZ7mAKswOfcTBY4vJKlTLMWJVWtGb5KScM9zlKlW3w2EE-BI1NiDhZt0xZeghLwhoyRGe9fKKK1Hpn5wlwfpghrZ1SslVWl5P0GucD2LjqyTFMNpeu9XiJ1sMFThAXd_GEjRFkytjZ6ddr9NLIKcGb53qOfnz9cnv5vbq--XZ1-em6UoyyXEnQY9OYriUDkyCpKX7IsacDAVBA2oaPgwQuGdM975ghLRSX9GiMHDQlIztH7zfdOYbfS_m1cDYpmKZtV8HqdiC861pa0HfP6DI60GKO1sn4IP5aXIBmA1QMKUUw_xBKxJqkOIotSbEmKbYky9jHbQzKnncWokjKglegbQSVhQ72_wJ_ACDUrUo
Cites_doi	10.1016/j.jchromb.2014.06.008 10.1016/0956-9618(94)80031-6 10.1016/j.jchromb.2017.03.005 10.1016/j.microc.2020.105350 10.1016/j.foodcont.2021.108576 10.1016/j.chemosphere.2023.139863 10.1016/j.scitotenv.2024.177830 10.1021/acs.jafc.0c05769 10.1016/j.foodchem.2019.125748 10.1016/j.chroma.2023.464547 10.1021/acs.jafc.2c00824 10.1016/j.aca.2015.05.032 10.1016/j.jchromb.2020.122369 10.1016/j.microc.2022.107539 10.1016/j.trac.2024.117909 10.1016/j.trac.2024.117903 10.1016/j.talanta.2020.122047 10.1016/j.envint.2016.11.026 10.1016/j.chroma.2024.465054 10.1016/j.scitotenv.2023.163044 10.1016/j.scitotenv.2024.173511 10.1016/S0956-9618(96)00161-0 10.1016/j.jes.2021.03.029 10.1016/j.talanta.2014.10.036 10.1021/acs.analchem.1c04415 10.1016/j.foodchem.2020.127113 10.1016/j.chroma.2018.11.030 10.1016/j.talanta.2021.122358 10.1021/acs.jafc.9b00113 10.1080/00986440701193845 10.1021/acs.analchem.0c01887 10.1016/j.jchromb.2024.124084 10.1016/j.foodchem.2019.03.001 10.1016/j.foodchem.2022.134755 10.1016/j.foodcont.2017.12.021 10.1016/j.foodchem.2024.139715 10.1016/S1570-0232(02)00035-1 10.1021/acs.analchem.4c00518
ContentType	Journal Article
Copyright	2025 Elsevier B.V. Copyright © 2025 Elsevier B.V. All rights reserved.
Copyright_xml	– notice: 2025 Elsevier B.V. – notice: Copyright © 2025 Elsevier B.V. All rights reserved.
DBID	AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8
DOI	10.1016/j.chroma.2025.466432
DatabaseName	CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic
DatabaseTitleList	MEDLINE - Academic MEDLINE
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Chemistry
EISSN	1873-3778
ExternalDocumentID	41061598 10_1016_j_chroma_2025_466432 S0021967325007769
Genre	Journal Article
GroupedDBID	--- --K --M -~X .~1 0R~ 1B1 1RT 1~. 1~5 4.4 457 4G. 5GY 5RE 5VS 7-5 71M 8P~ 9JN AABNK AAEDT AAEDW AAHBH AAIKJ AAKOC AALRI AAOAW AAQFI AARLI AATTM AAXKI AAXUO AAYWO ABFNM ABFRF ABJNI ABMAC ACDAQ ACGFO ACGFS ACLOT ACRLP ACVFH ADBBV ADCNI ADECG ADEZE AEBSH AEFWE AEIPS AEKER AENEX AEUPX AFJKZ AFPUW AFTJW AFZHZ AGHFR AGUBO AGYEJ AIEXJ AIGII AIIUN AIKHN AITUG AJSZI AKBMS AKRWK AKYEP ALMA_UNASSIGNED_HOLDINGS AMRAJ ANKPU APXCP AXJTR BKOJK BLXMC DU5 EBS EFJIC EFKBS EFLBG EO8 EO9 EP2 EP3 F5P FDB FLBIZ FNPLU FYGXN G-Q GBLVA IH2 IHE J1W KOM M36 M41 MO0 N9A O-L O9- OAUVE OZT P-8 P-9 P2P PC. Q38 ROL RPZ SCC SCH SDF SDG SDP SES SEW SPC SPCBC SSK SSZ T5K WH7 XPP YK3 ZMT ~02 ~G- ~HD ~KM .GJ 29K 53G 9DU AAYJJ AAYXX ABDPE ABXDB ACNNM AHHHB AI. AJQLL ASPBG AVWKF AZFZN CITATION D-I EJD FEDTE FGOYB HMU HVGLF HZ~ H~9 OHT SCB UQL VH1 WUQ ZGI ZKB ZXP CGR CUY CVF ECM EIF NPM 7X8
ID	FETCH-LOGICAL-c313t-aedb44f65093aea1f377ab8190eece0547b9ae7a33d8763f05e967dbffa9d10b3
ISICitedReferencesCount	0
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=001593303900001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	0021-9673 1873-3778
IngestDate	Thu Oct 09 19:01:18 EDT 2025 Mon Nov 03 02:00:56 EST 2025 Thu Nov 27 00:56:41 EST 2025 Wed Dec 10 14:25:22 EST 2025
IsPeerReviewed	true
IsScholarly	true
Keywords	Centrifuge Biomonitoring Advanced instrumental analysis Sample preparation Multiplexed method
Language	English
License	Copyright © 2025 Elsevier B.V. All rights reserved.
LinkModel	OpenURL
MergedId	FETCHMERGED-LOGICAL-c313t-aedb44f65093aea1f377ab8190eece0547b9ae7a33d8763f05e967dbffa9d10b3
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ORCID	0000-0002-4015-2557
PMID	41061598
PQID	3259076651
PQPubID	23479
ParticipantIDs	proquest_miscellaneous_3259076651 pubmed_primary_41061598 crossref_primary_10_1016_j_chroma_2025_466432 elsevier_sciencedirect_doi_10_1016_j_chroma_2025_466432
PublicationCentury	2000
PublicationDate	2025-11-22
PublicationDateYYYYMMDD	2025-11-22
PublicationDate_xml	– month: 11 year: 2025 text: 2025-11-22 day: 22
PublicationDecade	2020
PublicationPlace	Netherlands
PublicationPlace_xml	– name: Netherlands
PublicationTitle	Journal of Chromatography A
PublicationTitleAlternate	J Chromatogr A
PublicationYear	2025
Publisher	Elsevier B.V
Publisher_xml	– name: Elsevier B.V
References	Chen, Zhao, Miao, Wu (bib0028) 2015; 134 Chen, De Longhi, Gammacurta, Marchal, Darriet (bib0030) 1736 Bustamante, Bravo, Ruiz, Grimalt, Garí (bib0043) 2024; 1730 Li, Zeng, Liao, Tsunoda, Zhang, Xie, Wang, Li, Hu, Deng, Song (bib0008) 2020; 159 Chen, Miao, Zhao, Wu (bib0027) 2019; 1587 Chen, Yan, Lv, Zhao, Wu (bib0029) 2018; 88 Turnipseed (bib0020) 2024; 2024 Nam, Ji, Kang, Kim, Yang, Bok, Bae, Hong, Lee (bib0036) 2024; 96 Li, Ren, Zhang, Li, Zhao, Chen, Wu (bib0017) 2020; 328 Gao, Poma, Malarvannan, Dumitrascu, Bastiaensen, Wang, Covaci (bib0004) 2022; 111 Varenina, Bilandžić, Luburić, Kolanović, Varga (bib0023) 2022; 133 Chen, Liu, Barrett, Han, Lv, Li, Li, Zhao, Wu (bib0010) 2020; 68 Liu, Chen, Lyu, Wu, Li, Zhao, Wu (bib0011) 2022; 70 Xi, Onysio, Kacer, Nagorzanski, Shin, Cwiertny, Thompson (bib0002) 2024; 957 Rehm, Hankele, Ulbrich, Bigler (bib0037) 2021; 232 Gu, Gu, Zheng, Wiehl, Kopchick (bib0035) 1994; 4 Li, Chen, Lv, Li, Zhao, Wu (bib0015) 2020; 309 Bottinelli, Nicoli, Bévalot, Cartiser, Roger, Chikh, Kuuranne, Fanton, Guitton (bib0024) 2021; 225 Zhang, Mo, Lou, Ying, Wang, Dai (bib0042) 2023; 878 Barr, Needham (bib0007) 2002; 778 Wambua, Roman, Vidanage, Vidal, Calafat, Ospina (bib0005) 2023; 340 Oence, Gu (bib0013) 1996; 6 Chen, Miao, Zhao, Wu (bib0026) 2017; 1051 Wu, Ding (bib0038) 2023; 405 European Commission, 2019. Analytical quality control and method validation procedures for pesticide residues analysis in food and feed. SANTE/12682/2019. Zhang, Zhao, Pan, Zaya, Lyu, Li, Li, Zhao, Wu, Chen (bib0012) 2024; 941 Zhang, Wang, Zhang, Dai, Ding, Guo, Chen, Lu, Wu, Zhou (bib0044) 2024; 1237 Guerrini, Sunyer-Caldú, Gil-Solsona, Escribano, Vinaixa, Gago-Ferrero, Ramírez (bib0022) 2024; 180 Kaufmann (bib0025) 2020; 1158 Suwanvecho, Krčmová, Švec (bib0031) 2024; 180 Hewelt-Belka, Garwolińska, Belka, Bączek, Namieśnik, Kot-Wasik (bib0032) 2019; 288 de Barros Rodrigues, da Silva, Chong-Silva, Chong-Neto (bib0001) 2024 Mercier, Rouillon-Bartoletti, Dimeglio, Gilles, Lecorgne, Bonvallot, Le Bot (bib0006) 2022; 180 Pena-Pereira, Wojnowski, Tobiszewski (bib0039) 2020; 92 Manousi, Wojnowski, Plotka-Wasylka, Samanidou (bib0040) 2023; 25 Li, Chen, Lv, Li, Zhao, Wu (bib0019) 2019; 67 (bib0033) 2011 Hu, Ye, Li, Yan, Chen, Zhao (bib0018) 2024; 454 Gu, Zhang (bib0014) 2007; 194 Su, Lu, Li, Liu (bib0009) 2024; 1714 Yamamuro, Ohta, Aoyama, Watanabe (bib0041) 2014; 969 Yusa, Millet, Coscolla, Roca (bib0003) 2015; 891 Liu, Chen, Lyu, Li, Zhao, Wu (bib0016) 2022; 94 Andra, Austin, Patel, Dolios, Awawda, Arora (bib0021) 2017; 100 Andra (10.1016/j.chroma.2025.466432_bib0021) 2017; 100 Pena-Pereira (10.1016/j.chroma.2025.466432_bib0039) 2020; 92 Oence (10.1016/j.chroma.2025.466432_bib0013) 1996; 6 de Barros Rodrigues (10.1016/j.chroma.2025.466432_bib0001) 2024 Su (10.1016/j.chroma.2025.466432_bib0009) 2024; 1714 Barr (10.1016/j.chroma.2025.466432_bib0007) 2002; 778 Li (10.1016/j.chroma.2025.466432_bib0015) 2020; 309 Suwanvecho (10.1016/j.chroma.2025.466432_bib0031) 2024; 180 Zhang (10.1016/j.chroma.2025.466432_bib0042) 2023; 878 Gu (10.1016/j.chroma.2025.466432_bib0035) 1994; 4 Xi (10.1016/j.chroma.2025.466432_bib0002) 2024; 957 Manousi (10.1016/j.chroma.2025.466432_bib0040) 2023; 25 Gao (10.1016/j.chroma.2025.466432_bib0004) 2022; 111 Li (10.1016/j.chroma.2025.466432_bib0019) 2019; 67 Li (10.1016/j.chroma.2025.466432_bib0008) 2020; 159 Hu (10.1016/j.chroma.2025.466432_bib0018) 2024; 454 Chen (10.1016/j.chroma.2025.466432_bib0029) 2018; 88 Kaufmann (10.1016/j.chroma.2025.466432_bib0025) 2020; 1158 Nam (10.1016/j.chroma.2025.466432_bib0036) 2024; 96 Yusa (10.1016/j.chroma.2025.466432_bib0003) 2015; 891 Chen (10.1016/j.chroma.2025.466432_bib0010) 2020; 68 Rehm (10.1016/j.chroma.2025.466432_bib0037) 2021; 232 Chen (10.1016/j.chroma.2025.466432_bib0028) 2015; 134 Hewelt-Belka (10.1016/j.chroma.2025.466432_bib0032) 2019; 288 Guerrini (10.1016/j.chroma.2025.466432_bib0022) 2024; 180 Zhang (10.1016/j.chroma.2025.466432_bib0012) 2024; 941 Mercier (10.1016/j.chroma.2025.466432_bib0006) 2022; 180 Li (10.1016/j.chroma.2025.466432_bib0017) 2020; 328 Wu (10.1016/j.chroma.2025.466432_bib0038) 2023; 405 Varenina (10.1016/j.chroma.2025.466432_bib0023) 2022; 133 Bottinelli (10.1016/j.chroma.2025.466432_bib0024) 2021; 225 Bustamante (10.1016/j.chroma.2025.466432_bib0043) 2024; 1730 Wambua (10.1016/j.chroma.2025.466432_bib0005) 2023; 340 Turnipseed (10.1016/j.chroma.2025.466432_bib0020) 2024; 2024 (10.1016/j.chroma.2025.466432_bib0033) 2011 Zhang (10.1016/j.chroma.2025.466432_bib0044) 2024; 1237 Gu (10.1016/j.chroma.2025.466432_bib0014) 2007; 194 Liu (10.1016/j.chroma.2025.466432_bib0011) 2022; 70 Liu (10.1016/j.chroma.2025.466432_bib0016) 2022; 94 Yamamuro (10.1016/j.chroma.2025.466432_bib0041) 2014; 969 10.1016/j.chroma.2025.466432_bib0034 Chen (10.1016/j.chroma.2025.466432_bib0027) 2019; 1587 Chen (10.1016/j.chroma.2025.466432_bib0026) 2017; 1051 Chen (10.1016/j.chroma.2025.466432_bib0030) 1736
References_xml	– volume: 957 year: 2024 ident: bib0002 article-title: Small volume solid phase extraction method for comprehensive analysis of neonicotinoids, their metabolites, and related pesticides in water publication-title: Sci. Total Environ. – year: 2024 ident: bib0001 article-title: Pesticides and human health publication-title: J. de Pediatria – volume: 180 year: 2022 ident: bib0006 article-title: Simultaneous determination of selected pesticides and/or their metabolites in urine by off-line solid phase extraction and ultra high-performance liquid chromatography/hybrid quadrupole time-of-flight mass spectrometry publication-title: Microchem. J. – volume: 288 start-page: 154 year: 2019 end-page: 161 ident: bib0032 article-title: A new dilution-enrichment sample preparation strategy for expanded metabolome monitoring of human breast milk that overcomes the simultaneous presence of low- and high-abundance lipid species publication-title: Food Chem. – volume: 340 year: 2023 ident: bib0005 article-title: Online solid phase extraction high-performance liquid chromatography – Isotope dilution – Tandem mass spectrometry quantification of organophosphate pesticides, synthetic pyrethroids, and selected herbicide metabolites in human urine publication-title: Chemosphere – volume: 100 start-page: 32 year: 2017 end-page: 61 ident: bib0021 article-title: Trends in the application of high-resolution mass spectrometry for human biomonitoring: an analytical primer to studying the environmental chemical space of the human exposome publication-title: Environ. Int. – volume: 159 year: 2020 ident: bib0008 article-title: Magnetic nanoparticle-assisted in situ ionic liquid dispersive liquid-liquid microextraction of pyrethroid pesticides in urine samples publication-title: Microchem. J. – volume: 4 start-page: 258 year: 1994 end-page: 260 ident: bib0035 article-title: Phase separation of acetonitrile-water mixture in protein purification publication-title: Separat. Technol. – volume: 1237 year: 2024 ident: bib0044 article-title: Simultaneous determination of twelve neonicotinoids and six metabolites in human urine with isotope-dilution UPLC-Q-Orbitrap HRMS publication-title: J. Chromatogr. B – volume: 778 start-page: 5 year: 2002 end-page: 29 ident: bib0007 article-title: Analytical methods for biological monitoring of exposure to pesticides: a review publication-title: J. Chromatogr. B – volume: 67 start-page: 2732 year: 2019 end-page: 2740 ident: bib0019 article-title: Enhanced sensitivity and effective cleanup strategy for analysis of neonicotinoids in complex dietary samples and the application in the total diet study publication-title: J. Agric. Food Chem. – volume: 454 year: 2024 ident: bib0018 article-title: Enhanced selectivity for convenient extraction of acidic mycotoxins using a miniaturized centrifugal integrated cold-induced phase separation: determination of fumonisins and ochratoxins in cereals as a proof-of-concept study publication-title: Food Chem. – volume: 328 year: 2020 ident: bib0017 article-title: A highly-efficient and cost-effective pretreatment method for selective extraction and detection of perchlorate in tea and dairy products publication-title: Food Chem. – volume: 232 year: 2021 ident: bib0037 article-title: Simultaneous quantification of progestogens in plasma and serum by UHPLC-HRMS employing multiplexed targeted single ion monitoring publication-title: Talanta – volume: 133 year: 2022 ident: bib0023 article-title: High resolution mass spectrometry method for the determination of 13 antibiotic groups in bovine, swine, poultry and fish meat: an effective screening and confirmation analysis approach for routine laboratories publication-title: Food Control – volume: 88 start-page: 1 year: 2018 end-page: 8 ident: bib0029 article-title: Parallel reaction monitoring to improve the detection performance of carcinogenic 4-methylimidazole in food by liquid chromatography-high resolution mass spectrometry coupled with dispersive micro solid-phase extraction publication-title: Food Control – year: 1736 ident: bib0030 article-title: Quantitation of trace polyfunctional thiols in wine by liquid chromatography quadrupole Orbitrap high-resolution mass spectrometry in parallel reaction monitoring publication-title: J. Chromatogr. A – volume: 92 start-page: 10076 year: 2020 end-page: 10082 ident: bib0039 article-title: AGREE-analytical GREEnness metric approach and software publication-title: Anal. Chem. – volume: 1714 year: 2024 ident: bib0009 article-title: Establishment of a modified QuEChERS extraction and liquid chromatography-tandem mass spectrometry method for multiple pesticide residues followed by determination of the residue levels and exposure assessment in livestock urine publication-title: J. Chromatogr. A – volume: 194 start-page: 828 year: 2007 end-page: 834 ident: bib0014 article-title: Partition coefficients of some antibiotics, peptides and amino acids in liquid-liquid partitioning of the acetonitrile-water system at subzero temperatures publication-title: Chem. Eng. Commun. – volume: 878 year: 2023 ident: bib0042 article-title: Occurrence, distribution and potential risk to infants of neonicotinoids in breast milk: a case study in Hangzhou, China publication-title: Sci. Total Environ. – volume: 94 start-page: 4227 year: 2022 end-page: 4235 ident: bib0016 article-title: Generic enrichment of organic contaminants in Human biomonitoring: application in monitoring early life exposures to fipronil via breast milk publication-title: Anal. Chem. – volume: 6 start-page: 261 year: 1996 end-page: 264 ident: bib0013 article-title: Liquid-liquid equilibrium of the acetonitrile-water system for protein purification publication-title: Separat. Technol. – volume: 405 year: 2023 ident: bib0038 article-title: Evaluation of matrix effects for pesticide residue analysis by QuEChERs Nationwide Biomonitoring of Neonicotinoid coupled with UHPLC-MS/MS in complex herbal matrix publication-title: Food Chem. – volume: 891 start-page: 15 year: 2015 end-page: 31 ident: bib0003 article-title: Analytical methods for human biomonitoring of pesticides. A review publication-title: Anal. Chim. Acta – volume: 111 start-page: 153 year: 2022 end-page: 163 ident: bib0004 article-title: Development of an analytical method based on solid-phase extraction and LC-MS/MS for the monitoring of current-use pesticides and their metabolites in human urine publication-title: J. Environ. Sci. – volume: 309 year: 2020 ident: bib0015 article-title: One-step cold-induced aqueous two-phase system for the simultaneous determination of fipronil and its metabolites in dietary samples by liquid chromatography–high resolution mass spectrometry and the application in Total Diet Study publication-title: Food Chem. – volume: 1587 start-page: 73 year: 2019 end-page: 78 ident: bib0027 article-title: A simple liquid chromatography-high resolution mass spectrometry method for the determination of glyphosate and aminomethylphosphonic acid in human urine using cold-induced phase separation and hydrophilic pipette tip solid-phase extraction publication-title: J. Chromatogr. A – volume: 1051 start-page: 92 year: 2017 end-page: 96 ident: bib0026 article-title: Dispersive micro solid phase extraction of amantadine, rimantadine and memantine in chicken muscle with magnetic cation exchange polymer publication-title: J. Chromatogr. B – volume: 96 start-page: 10219 year: 2024 end-page: 10227 ident: bib0036 article-title: Wideband PRM: highly accurate and sensitive method for high-throughput targeted proteomics publication-title: Anal. Chem. – volume: 25 start-page: 7598 year: 2023 end-page: 7604 ident: bib0040 article-title: Blue applicability grade index (BAGI) and software: a new tool for the evaluation of method practicality publication-title: Green Chem.: Int. J. Green Chem. Resour.: GC – volume: 180 year: 2024 ident: bib0022 article-title: Early-life chemical exposome: comprehensive strategies for wide-scope screening of organic compounds publication-title: TrAC Trends Analyt. Chem. – volume: 1730 year: 2024 ident: bib0043 article-title: Method optimization for a simultaneous determination of neonicotinoid, carbamate/thiocarbamate, triazole, organophosphate and pyrethroid pesticides and their metabolites in urine using UPLC-MS/MS publication-title: J. Chromatogr. A – reference: European Commission, 2019. Analytical quality control and method validation procedures for pesticide residues analysis in food and feed. SANTE/12682/2019. – volume: 180 year: 2024 ident: bib0031 article-title: Centrifugal-assisted sample preparation techniques: innovations and applications in bioanalysis publication-title: TrAC Trends Analyt. Chem. – year: 2011 ident: bib0033 article-title: Committee for Medicinal Products for Human Use, Guideline on Bioanalytical Method Validation – volume: 70 start-page: 4467 year: 2022 end-page: 4474 ident: bib0011 article-title: Occurrence of phenylpyrazole and diamide insecticides in lactating women and their health risks for infants publication-title: J. Agric. Food Chem. – volume: 941 year: 2024 ident: bib0012 article-title: The mother-offspring transfer of chlorothalonil through human breast milk: a multi-city cross-sectional study publication-title: Sci. Total Environ. – volume: 1158 year: 2020 ident: bib0025 article-title: The use of UHPLC, IMS, and HRMS in multiresidue analytical methods: a critical review publication-title: J. Chromatogr. B – volume: 68 start-page: 13906 year: 2020 end-page: 13915 ident: bib0010 article-title: Nationwide biomonitoring of neonicotinoid insecticides in breast milk and health risk assessment to nursing infants in the Chinese population publication-title: J. Agric. Food Chem. – volume: 969 start-page: 85 year: 2014 end-page: 94 ident: bib0041 article-title: Simultaneous determination of neonicotinoid insecticides in human serum and urine using diatomaceous earth-assisted extraction and liquid chromatography–tandem mass spectrometry publication-title: J. Chromatogr. B – volume: 2024 year: 2024 ident: bib0020 article-title: Analysis of chemical contaminants in fish using high resolution mass spectrometry – A review publication-title: Trends Environ. Analyt. Chem. – volume: 225 year: 2021 ident: bib0024 article-title: Development and validation of a method for quantification of human insulin and its synthetic analogues in plasma and post-mortem sera by LC-MS/HRMS publication-title: Talanta – volume: 134 start-page: 144 year: 2015 end-page: 152 ident: bib0028 article-title: A novel dispersive micro solid phase extraction using PCX as the sorbent for the determination of melamine and cyromazine in milk and milk powder by UHPLC-HRMS/MS publication-title: Talanta – volume: 969 start-page: 85 year: 2014 ident: 10.1016/j.chroma.2025.466432_bib0041 article-title: Simultaneous determination of neonicotinoid insecticides in human serum and urine using diatomaceous earth-assisted extraction and liquid chromatography–tandem mass spectrometry publication-title: J. Chromatogr. B doi: 10.1016/j.jchromb.2014.06.008 – volume: 4 start-page: 258 year: 1994 ident: 10.1016/j.chroma.2025.466432_bib0035 article-title: Phase separation of acetonitrile-water mixture in protein purification publication-title: Separat. Technol. doi: 10.1016/0956-9618(94)80031-6 – volume: 1051 start-page: 92 year: 2017 ident: 10.1016/j.chroma.2025.466432_bib0026 article-title: Dispersive micro solid phase extraction of amantadine, rimantadine and memantine in chicken muscle with magnetic cation exchange polymer publication-title: J. Chromatogr. B doi: 10.1016/j.jchromb.2017.03.005 – volume: 2024 issue: 42 year: 2024 ident: 10.1016/j.chroma.2025.466432_bib0020 article-title: Analysis of chemical contaminants in fish using high resolution mass spectrometry – A review publication-title: Trends Environ. Analyt. Chem. – ident: 10.1016/j.chroma.2025.466432_bib0034 – volume: 159 year: 2020 ident: 10.1016/j.chroma.2025.466432_bib0008 article-title: Magnetic nanoparticle-assisted in situ ionic liquid dispersive liquid-liquid microextraction of pyrethroid pesticides in urine samples publication-title: Microchem. J. doi: 10.1016/j.microc.2020.105350 – volume: 133 year: 2022 ident: 10.1016/j.chroma.2025.466432_bib0023 article-title: High resolution mass spectrometry method for the determination of 13 antibiotic groups in bovine, swine, poultry and fish meat: an effective screening and confirmation analysis approach for routine laboratories publication-title: Food Control doi: 10.1016/j.foodcont.2021.108576 – volume: 340 year: 2023 ident: 10.1016/j.chroma.2025.466432_bib0005 article-title: Online solid phase extraction high-performance liquid chromatography – Isotope dilution – Tandem mass spectrometry quantification of organophosphate pesticides, synthetic pyrethroids, and selected herbicide metabolites in human urine publication-title: Chemosphere doi: 10.1016/j.chemosphere.2023.139863 – volume: 957 year: 2024 ident: 10.1016/j.chroma.2025.466432_bib0002 article-title: Small volume solid phase extraction method for comprehensive analysis of neonicotinoids, their metabolites, and related pesticides in water publication-title: Sci. Total Environ. doi: 10.1016/j.scitotenv.2024.177830 – volume: 68 start-page: 13906 year: 2020 ident: 10.1016/j.chroma.2025.466432_bib0010 article-title: Nationwide biomonitoring of neonicotinoid insecticides in breast milk and health risk assessment to nursing infants in the Chinese population publication-title: J. Agric. Food Chem. doi: 10.1021/acs.jafc.0c05769 – volume: 309 year: 2020 ident: 10.1016/j.chroma.2025.466432_bib0015 article-title: One-step cold-induced aqueous two-phase system for the simultaneous determination of fipronil and its metabolites in dietary samples by liquid chromatography–high resolution mass spectrometry and the application in Total Diet Study publication-title: Food Chem. doi: 10.1016/j.foodchem.2019.125748 – volume: 1714 year: 2024 ident: 10.1016/j.chroma.2025.466432_bib0009 article-title: Establishment of a modified QuEChERS extraction and liquid chromatography-tandem mass spectrometry method for multiple pesticide residues followed by determination of the residue levels and exposure assessment in livestock urine publication-title: J. Chromatogr. A doi: 10.1016/j.chroma.2023.464547 – volume: 70 start-page: 4467 year: 2022 ident: 10.1016/j.chroma.2025.466432_bib0011 article-title: Occurrence of phenylpyrazole and diamide insecticides in lactating women and their health risks for infants publication-title: J. Agric. Food Chem. doi: 10.1021/acs.jafc.2c00824 – volume: 891 start-page: 15 year: 2015 ident: 10.1016/j.chroma.2025.466432_bib0003 article-title: Analytical methods for human biomonitoring of pesticides. A review publication-title: Anal. Chim. Acta doi: 10.1016/j.aca.2015.05.032 – year: 1736 ident: 10.1016/j.chroma.2025.466432_bib0030 article-title: Quantitation of trace polyfunctional thiols in wine by liquid chromatography quadrupole Orbitrap high-resolution mass spectrometry in parallel reaction monitoring publication-title: J. Chromatogr. A – volume: 1158 year: 2020 ident: 10.1016/j.chroma.2025.466432_bib0025 article-title: The use of UHPLC, IMS, and HRMS in multiresidue analytical methods: a critical review publication-title: J. Chromatogr. B doi: 10.1016/j.jchromb.2020.122369 – volume: 180 year: 2022 ident: 10.1016/j.chroma.2025.466432_bib0006 article-title: Simultaneous determination of selected pesticides and/or their metabolites in urine by off-line solid phase extraction and ultra high-performance liquid chromatography/hybrid quadrupole time-of-flight mass spectrometry publication-title: Microchem. J. doi: 10.1016/j.microc.2022.107539 – volume: 180 year: 2024 ident: 10.1016/j.chroma.2025.466432_bib0031 article-title: Centrifugal-assisted sample preparation techniques: innovations and applications in bioanalysis publication-title: TrAC Trends Analyt. Chem. doi: 10.1016/j.trac.2024.117909 – volume: 180 year: 2024 ident: 10.1016/j.chroma.2025.466432_bib0022 article-title: Early-life chemical exposome: comprehensive strategies for wide-scope screening of organic compounds publication-title: TrAC Trends Analyt. Chem. doi: 10.1016/j.trac.2024.117903 – volume: 225 year: 2021 ident: 10.1016/j.chroma.2025.466432_bib0024 article-title: Development and validation of a method for quantification of human insulin and its synthetic analogues in plasma and post-mortem sera by LC-MS/HRMS publication-title: Talanta doi: 10.1016/j.talanta.2020.122047 – volume: 100 start-page: 32 year: 2017 ident: 10.1016/j.chroma.2025.466432_bib0021 article-title: Trends in the application of high-resolution mass spectrometry for human biomonitoring: an analytical primer to studying the environmental chemical space of the human exposome publication-title: Environ. Int. doi: 10.1016/j.envint.2016.11.026 – volume: 1730 year: 2024 ident: 10.1016/j.chroma.2025.466432_bib0043 article-title: Method optimization for a simultaneous determination of neonicotinoid, carbamate/thiocarbamate, triazole, organophosphate and pyrethroid pesticides and their metabolites in urine using UPLC-MS/MS publication-title: J. Chromatogr. A doi: 10.1016/j.chroma.2024.465054 – volume: 878 year: 2023 ident: 10.1016/j.chroma.2025.466432_bib0042 article-title: Occurrence, distribution and potential risk to infants of neonicotinoids in breast milk: a case study in Hangzhou, China publication-title: Sci. Total Environ. doi: 10.1016/j.scitotenv.2023.163044 – volume: 941 year: 2024 ident: 10.1016/j.chroma.2025.466432_bib0012 article-title: The mother-offspring transfer of chlorothalonil through human breast milk: a multi-city cross-sectional study publication-title: Sci. Total Environ. doi: 10.1016/j.scitotenv.2024.173511 – volume: 6 start-page: 261 year: 1996 ident: 10.1016/j.chroma.2025.466432_bib0013 article-title: Liquid-liquid equilibrium of the acetonitrile-water system for protein purification publication-title: Separat. Technol. doi: 10.1016/S0956-9618(96)00161-0 – volume: 111 start-page: 153 year: 2022 ident: 10.1016/j.chroma.2025.466432_bib0004 article-title: Development of an analytical method based on solid-phase extraction and LC-MS/MS for the monitoring of current-use pesticides and their metabolites in human urine publication-title: J. Environ. Sci. doi: 10.1016/j.jes.2021.03.029 – volume: 134 start-page: 144 year: 2015 ident: 10.1016/j.chroma.2025.466432_bib0028 article-title: A novel dispersive micro solid phase extraction using PCX as the sorbent for the determination of melamine and cyromazine in milk and milk powder by UHPLC-HRMS/MS publication-title: Talanta doi: 10.1016/j.talanta.2014.10.036 – volume: 25 start-page: 7598 year: 2023 ident: 10.1016/j.chroma.2025.466432_bib0040 article-title: Blue applicability grade index (BAGI) and software: a new tool for the evaluation of method practicality publication-title: Green Chem.: Int. J. Green Chem. Resour.: GC – volume: 94 start-page: 4227 issue: 10 year: 2022 ident: 10.1016/j.chroma.2025.466432_bib0016 article-title: Generic enrichment of organic contaminants in Human biomonitoring: application in monitoring early life exposures to fipronil via breast milk publication-title: Anal. Chem. doi: 10.1021/acs.analchem.1c04415 – volume: 328 year: 2020 ident: 10.1016/j.chroma.2025.466432_bib0017 article-title: A highly-efficient and cost-effective pretreatment method for selective extraction and detection of perchlorate in tea and dairy products publication-title: Food Chem. doi: 10.1016/j.foodchem.2020.127113 – volume: 1587 start-page: 73 year: 2019 ident: 10.1016/j.chroma.2025.466432_bib0027 article-title: A simple liquid chromatography-high resolution mass spectrometry method for the determination of glyphosate and aminomethylphosphonic acid in human urine using cold-induced phase separation and hydrophilic pipette tip solid-phase extraction publication-title: J. Chromatogr. A doi: 10.1016/j.chroma.2018.11.030 – volume: 232 year: 2021 ident: 10.1016/j.chroma.2025.466432_bib0037 article-title: Simultaneous quantification of progestogens in plasma and serum by UHPLC-HRMS employing multiplexed targeted single ion monitoring publication-title: Talanta doi: 10.1016/j.talanta.2021.122358 – volume: 67 start-page: 2732 year: 2019 ident: 10.1016/j.chroma.2025.466432_bib0019 article-title: Enhanced sensitivity and effective cleanup strategy for analysis of neonicotinoids in complex dietary samples and the application in the total diet study publication-title: J. Agric. Food Chem. doi: 10.1021/acs.jafc.9b00113 – year: 2024 ident: 10.1016/j.chroma.2025.466432_bib0001 article-title: Pesticides and human health publication-title: J. de Pediatria – volume: 194 start-page: 828 year: 2007 ident: 10.1016/j.chroma.2025.466432_bib0014 article-title: Partition coefficients of some antibiotics, peptides and amino acids in liquid-liquid partitioning of the acetonitrile-water system at subzero temperatures publication-title: Chem. Eng. Commun. doi: 10.1080/00986440701193845 – volume: 92 start-page: 10076 year: 2020 ident: 10.1016/j.chroma.2025.466432_bib0039 article-title: AGREE-analytical GREEnness metric approach and software publication-title: Anal. Chem. doi: 10.1021/acs.analchem.0c01887 – volume: 1237 year: 2024 ident: 10.1016/j.chroma.2025.466432_bib0044 article-title: Simultaneous determination of twelve neonicotinoids and six metabolites in human urine with isotope-dilution UPLC-Q-Orbitrap HRMS publication-title: J. Chromatogr. B doi: 10.1016/j.jchromb.2024.124084 – volume: 288 start-page: 154 year: 2019 ident: 10.1016/j.chroma.2025.466432_bib0032 article-title: A new dilution-enrichment sample preparation strategy for expanded metabolome monitoring of human breast milk that overcomes the simultaneous presence of low- and high-abundance lipid species publication-title: Food Chem. doi: 10.1016/j.foodchem.2019.03.001 – volume: 405 year: 2023 ident: 10.1016/j.chroma.2025.466432_bib0038 article-title: Evaluation of matrix effects for pesticide residue analysis by QuEChERs Nationwide Biomonitoring of Neonicotinoid coupled with UHPLC-MS/MS in complex herbal matrix publication-title: Food Chem. doi: 10.1016/j.foodchem.2022.134755 – volume: 88 start-page: 1 year: 2018 ident: 10.1016/j.chroma.2025.466432_bib0029 article-title: Parallel reaction monitoring to improve the detection performance of carcinogenic 4-methylimidazole in food by liquid chromatography-high resolution mass spectrometry coupled with dispersive micro solid-phase extraction publication-title: Food Control doi: 10.1016/j.foodcont.2017.12.021 – year: 2011 ident: 10.1016/j.chroma.2025.466432_bib0033 – volume: 454 year: 2024 ident: 10.1016/j.chroma.2025.466432_bib0018 article-title: Enhanced selectivity for convenient extraction of acidic mycotoxins using a miniaturized centrifugal integrated cold-induced phase separation: determination of fumonisins and ochratoxins in cereals as a proof-of-concept study publication-title: Food Chem. doi: 10.1016/j.foodchem.2024.139715 – volume: 778 start-page: 5 year: 2002 ident: 10.1016/j.chroma.2025.466432_bib0007 article-title: Analytical methods for biological monitoring of exposure to pesticides: a review publication-title: J. Chromatogr. B doi: 10.1016/S1570-0232(02)00035-1 – volume: 96 start-page: 10219 year: 2024 ident: 10.1016/j.chroma.2025.466432_bib0036 article-title: Wideband PRM: highly accurate and sensitive method for high-throughput targeted proteomics publication-title: Anal. Chem. doi: 10.1021/acs.analchem.4c00518
SSID	ssj0017072 ssj0029838
Score	2.4910612
Snippet	•A one-step centrifugal-assisted CIPS method was developed in biological samples.•Centrifugal-assisted technique enhances performance in sample... An efficient and highly sensitive analytical method was developed for the simultaneous determination of neonicotinoids, benzopyrazoles, diamide insecticides...
SourceID	proquest pubmed crossref elsevier
SourceType	Aggregation Database Index Database Publisher
StartPage	466432
SubjectTerms	Advanced instrumental analysis Biomonitoring Centrifugation - methods Centrifuge Chromatography, Liquid - methods Female Humans Limit of Detection Linear Models Milk, Human - chemistry Multiplexed method Pesticide Residues - analysis Pesticide Residues - blood Pesticide Residues - isolation & purification Pesticide Residues - urine Pesticides - analysis Pesticides - blood Pesticides - isolation & purification Pesticides - metabolism Pesticides - urine Reproducibility of Results Sample preparation
Title	Development of a one-step centrifugal extraction method for simultaneous determination of multiple types of pesticides and their metabolites in urine, serum, and breast milk
URI	https://dx.doi.org/10.1016/j.chroma.2025.466432 https://www.ncbi.nlm.nih.gov/pubmed/41061598 https://www.proquest.com/docview/3259076651
Volume	1763
WOSCitedRecordID	wos001593303900001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVESC databaseName: Elsevier SD Freedom Collection Journals 2021 customDbUrl: eissn: 1873-3778 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0029838 issn: 0021-9673 databaseCode: AIEXJ dateStart: 19950106 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1db9MwFLW6Dom9IL7ZgMlIvHWpmjiJk8epGoIJqj0M6FvkJPaWMdIobaf9KX4M_4h77TjJmArsgZeotVLHyTn1vbk-vpeQt5GSvmBhDK8luef4CqsBipQ5MF96EdgnFesV3S8f-WwWzefxyWDw0-6FubrkZRldX8fVf4Ua2gBs3Dp7B7jbTqEBPgPocATY4fhPwPdkQGbz46KUDmBZjbQQs1BrMAojmJPrpky4KSKt9YbLAgWGopQojM2tUsY6la34EOO2WgJSYY6OrMjl0ioxixr7A2bh3mattcVwvineKGtTVBlPTVEMvxp9Ly6_bfCPMW0vuNNNSu0u5tqGuKfnRb9NL7OcF5VsbDGqjLRU4Ris89ladM1f19rwLMqz0hruJu7hBbgB0OuHQrW4JDSFUNq53E6XZjrG3PkmfHrLUpigxcU40zczxiuMu9NvJub-zWC2MkarkLtITC8J9pKYXrbItseDOBqS7cMPR_PjdmmLT3ib4MyLI2Z8heZe7OZOrUC8PbRNztOmlyPtJJ0-JA8a9OihYeUjMpDlY3J_aosKPiE_euykC0UFteykPXbSjp3UsJMCO2mfnfQGO7Ery06q2YktHTspUI5qdtIeO2lRUs3OA6q5eaBPM8ykyMyn5PO7o9Ppe6epGOJkzGUrR8g89X2FWSGZkMJVjHORotMrZSbh7YSnsZBcMJZjJkY1CSQ89TxVSsS5O0nZMzIs4b5fEKrSQIXgXwcKPGClVJxNssCTXoZBBtd3d4ljoUgqkxgm-RMfdgm3eCWNc2uc1gQY-ZdfvrHwJoAWLuiZJ50wL4gnPAwDGM1zg3s7Fh9jPcC_vTuO8yXZ6f5tr8hwVa_la3Ivu1oVy3qfbPF5tN9QGr7NTj79AlZr5WY
linkProvider	Elsevier
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Development+of+a+one-step+centrifugal+extraction+method+for+simultaneous+determination+of+multiple+types+of+pesticides+and+their+metabolites+in+urine%2C+serum%2C+and+breast+milk&rft.jtitle=Journal+of+Chromatography+A&rft.au=Zhang%2C+Chi&rft.au=Zhan%2C+Zhipeng&rft.au=Li%2C+Jingguang&rft.au=Wu%2C+Yongning&rft.date=2025-11-22&rft.issn=0021-9673&rft.volume=1763&rft.spage=466432&rft_id=info:doi/10.1016%2Fj.chroma.2025.466432&rft.externalDBID=n%2Fa&rft.externalDocID=10_1016_j_chroma_2025_466432
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0021-9673&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0021-9673&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0021-9673&client=summon