USP33-mediated stabilization of c-Myc drives glycolytic reprogramming and promotes ovarian cancer progression

Ovarian cancer (OC) is one of the most lethal gynecological malignancies, characterized by late-stage presentation, high recurrence rates, and a lack of effective early diagnostic markers. Recent evidence suggests that deubiquitinating enzymes (DUBs) play pivotal roles in tumor development and metab...

Full description

Saved in:

Bibliographic Details
Published in:	Biochimica et biophysica acta. General subjects Vol. 1869; no. 9; p. 130830
Main Authors:	Chen, Dejia, Zhao, Yue, Zhang, Xiaobo, Shi, Xiaocheng, Liu, Yiming, Lou, Ge
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.08.2025
Subjects:	Apoptosis C-Myc Cell Line, Tumor Cell Movement Cell Proliferation Deubiquitination Disease Progression Female Gene Expression Regulation, Neoplastic Glycolysis Humans Metabolic reprogramming Ovarian cancer Ovarian Neoplasms - genetics Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Protein Stability Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism SP33 Ubiquitin Thiolesterase - genetics Ubiquitin Thiolesterase - metabolism C-Myc Glycolysis SP33 Metabolic reprogramming Deubiquitination Ovarian cancer
ISSN:	0304-4165, 1872-8006, 1872-8006
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!