USP33-mediated stabilization of c-Myc drives glycolytic reprogramming and promotes ovarian cancer progression

Ovarian cancer (OC) is one of the most lethal gynecological malignancies, characterized by late-stage presentation, high recurrence rates, and a lack of effective early diagnostic markers. Recent evidence suggests that deubiquitinating enzymes (DUBs) play pivotal roles in tumor development and metab...

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Veröffentlicht in:	Biochimica et biophysica acta. General subjects Jg. 1869; H. 9; S. 130830
Hauptverfasser:	Chen, Dejia, Zhao, Yue, Zhang, Xiaobo, Shi, Xiaocheng, Liu, Yiming, Lou, Ge
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Netherlands Elsevier B.V 01.08.2025
Schlagworte:	Apoptosis C-Myc Cell Line, Tumor Cell Movement Cell Proliferation Deubiquitination Disease Progression Female Gene Expression Regulation, Neoplastic Glycolysis Humans Metabolic reprogramming Ovarian cancer Ovarian Neoplasms - genetics Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Protein Stability Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism SP33 Ubiquitin Thiolesterase - genetics Ubiquitin Thiolesterase - metabolism C-Myc Glycolysis SP33 Metabolic reprogramming Deubiquitination Ovarian cancer
ISSN:	0304-4165, 1872-8006, 1872-8006
Online-Zugang:	Volltext
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