Prenatal Exposure to PM2.5 Oxidative Potential and Lung Function in Infants and Preschool- Age Children: A Prospective Study

Fine particulate matter (PM2.5) has been found to be detrimental to respiratory health of children, but few studies have examined the effects of prenatal PM2.5 oxidative potential (OP) on lung function in infants and preschool children.BACKGROUNDFine particulate matter (PM2.5) has been found to be d...

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Published in:Environmental health perspectives Vol. 131; no. 1; pp. 17004 - 224
Main Authors: Marsal, Anouk, Slama, Rémy, Lyon-Caen, Sarah, Borlaza, Lucille Joanna S., Jaffrezo, Jean-Luc, Boudier, Anne, Darfeuil, Sophie, Elazzouzi, Rhabira, Gioria, Yoann, Lepeule, Johanna, Chartier, Ryan, Pin, Isabelle, Quentin, Joane, Bayat, Sam, Uzu, Gaëlle, Siroux, Valérie
Format: Journal Article
Language:English
Published: National Institute of Environmental Health Sciences 01.01.2023
Environmental Health Perspectives
Subjects:
Environmental Sciences
Human health and pathology
Life Sciences
Pulmonology and respiratory tract
Santé publique et épidémiologie
ISSN:0091-6765, 1552-9924, 1552-9924
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Abstract Fine particulate matter (PM2.5) has been found to be detrimental to respiratory health of children, but few studies have examined the effects of prenatal PM2.5 oxidative potential (OP) on lung function in infants and preschool children.BACKGROUNDFine particulate matter (PM2.5) has been found to be detrimental to respiratory health of children, but few studies have examined the effects of prenatal PM2.5 oxidative potential (OP) on lung function in infants and preschool children.We estimated the associations of personal exposure to PM2.5 and OP during pregnancy on offspring objective lung function parameters and compared the strengths of associations between both exposure metrics.OBJECTIVESWe estimated the associations of personal exposure to PM2.5 and OP during pregnancy on offspring objective lung function parameters and compared the strengths of associations between both exposure metrics.We used data from 356 mother-child pairs from the SEPAGES cohort. PM filters collected twice during a week were analyzed for OP, using the dithiothreitol (DTT) and the ascorbic acid (AA) assays, quantifying the exposure of each pregnant woman. Lung function was assessed with tidal breathing analysis (TBFVL) and nitrogen multiple-breath washout (N2MBW) test, performed at 6 wk, and airwave oscillometry (AOS) performed at 3 y. Associations of prenatal PM2.5 mass and OP with lung function parameters were estimated using multiple linear regressions.METHODSWe used data from 356 mother-child pairs from the SEPAGES cohort. PM filters collected twice during a week were analyzed for OP, using the dithiothreitol (DTT) and the ascorbic acid (AA) assays, quantifying the exposure of each pregnant woman. Lung function was assessed with tidal breathing analysis (TBFVL) and nitrogen multiple-breath washout (N2MBW) test, performed at 6 wk, and airwave oscillometry (AOS) performed at 3 y. Associations of prenatal PM2.5 mass and OP with lung function parameters were estimated using multiple linear regressions.In neonates, an interquartile (IQR) increase in OPvDTT (0.89 nmol/min/m3) was associated with a decrease in functional residual capacity (FRC) measured by N2MBW [β=-2.26mL; 95% confidence interval (CI): -4.68, 0.15]. Associations with PM2.5 showed similar patterns in comparison with OPvDTT but of smaller magnitude. Lung clearance index (LCI) and TBFVL parameters did not show any clear association with the exposures considered. At 3 y, increased frequency-dependent resistance of the lungs (Rrs7-19) from AOS tended to be associated with higher OPvDTT (β=0.09 hPa×s/L; 95% CI: -0.06, 0.24) and OPvAA (IQR=1.14 nmol/min/m3; β=0.12 hPa×s/L; 95% CI: -0.04, 0.27) but not with PM2.5 (IQR=6.9 μg/m3; β=0.02 hPa×s/L; 95% CI: -0.13, 0.16). Results for FRC and Rrs7-19 remained similar in OP models adjusted on PM2.5.RESULTSIn neonates, an interquartile (IQR) increase in OPvDTT (0.89 nmol/min/m3) was associated with a decrease in functional residual capacity (FRC) measured by N2MBW [β=-2.26mL; 95% confidence interval (CI): -4.68, 0.15]. Associations with PM2.5 showed similar patterns in comparison with OPvDTT but of smaller magnitude. Lung clearance index (LCI) and TBFVL parameters did not show any clear association with the exposures considered. At 3 y, increased frequency-dependent resistance of the lungs (Rrs7-19) from AOS tended to be associated with higher OPvDTT (β=0.09 hPa×s/L; 95% CI: -0.06, 0.24) and OPvAA (IQR=1.14 nmol/min/m3; β=0.12 hPa×s/L; 95% CI: -0.04, 0.27) but not with PM2.5 (IQR=6.9 μg/m3; β=0.02 hPa×s/L; 95% CI: -0.13, 0.16). Results for FRC and Rrs7-19 remained similar in OP models adjusted on PM2.5.Prenatal exposure to OPvDTT was associated with several offspring lung function parameters over time, all related to lung volumes. https://doi.org/10.1289/EHP11155.DISCUSSIONPrenatal exposure to OPvDTT was associated with several offspring lung function parameters over time, all related to lung volumes. https://doi.org/10.1289/EHP11155.
AbstractList BACKGROUND: Fine particulate matter (PM 2:5) has been found to be detrimental to respiratory health of children, but few studies have examined the effects of prenatal PM 2:5 oxidative potential (OP) on lung function in infants and preschool children. OBJECTIVES: We estimated the associations of personal exposure to PM 2:5 and OP during pregnancy on offspring objective lung function parameters and compared the strengths of associations between both exposure metrics. METHODS: We used data from 356 mother-child pairs from the SEPAGES cohort. PM filters collected twice during a week were analyzed for OP, using the dithiothreitol (DTT) and the ascorbic acid (AA) assays, quantifying the exposure of each pregnant woman. Lung function was assessed with tidal breathing analysis (TBFVL) and nitrogen multiple-breath washout (N 2 MBW) test, performed at 6 wk, and airwave oscillometry (AOS) performed at 3 y. Associations of prenatal PM 2:5 mass and OP with lung function parameters were estimated using multiple linear regressions. RESULTS: In neonates, an interquartile (IQR) increase in OP DTT v (0:89 nmol=min=m 3) was associated with a decrease in functional residual capacity (FRC) measured by N 2 MBW [b = − 2:26 mL; 95% confidence interval (CI): −4:68, 0.15]. Associations with PM 2:5 showed similar patterns in comparison with OP DTT v but of smaller magnitude. Lung clearance index (LCI) and TBFVL parameters did not show any clear association with the exposures considered. At 3 y, increased frequency-dependent resistance of the lungs (Rrs 7-19) from AOS tended to be associated with higher OP DTT v
Fine particulate matter (PM2.5) has been found to be detrimental to respiratory health of children, but few studies have examined the effects of prenatal PM2.5 oxidative potential (OP) on lung function in infants and preschool children.BACKGROUNDFine particulate matter (PM2.5) has been found to be detrimental to respiratory health of children, but few studies have examined the effects of prenatal PM2.5 oxidative potential (OP) on lung function in infants and preschool children.We estimated the associations of personal exposure to PM2.5 and OP during pregnancy on offspring objective lung function parameters and compared the strengths of associations between both exposure metrics.OBJECTIVESWe estimated the associations of personal exposure to PM2.5 and OP during pregnancy on offspring objective lung function parameters and compared the strengths of associations between both exposure metrics.We used data from 356 mother-child pairs from the SEPAGES cohort. PM filters collected twice during a week were analyzed for OP, using the dithiothreitol (DTT) and the ascorbic acid (AA) assays, quantifying the exposure of each pregnant woman. Lung function was assessed with tidal breathing analysis (TBFVL) and nitrogen multiple-breath washout (N2MBW) test, performed at 6 wk, and airwave oscillometry (AOS) performed at 3 y. Associations of prenatal PM2.5 mass and OP with lung function parameters were estimated using multiple linear regressions.METHODSWe used data from 356 mother-child pairs from the SEPAGES cohort. PM filters collected twice during a week were analyzed for OP, using the dithiothreitol (DTT) and the ascorbic acid (AA) assays, quantifying the exposure of each pregnant woman. Lung function was assessed with tidal breathing analysis (TBFVL) and nitrogen multiple-breath washout (N2MBW) test, performed at 6 wk, and airwave oscillometry (AOS) performed at 3 y. Associations of prenatal PM2.5 mass and OP with lung function parameters were estimated using multiple linear regressions.In neonates, an interquartile (IQR) increase in OPvDTT (0.89 nmol/min/m3) was associated with a decrease in functional residual capacity (FRC) measured by N2MBW [β=-2.26mL; 95% confidence interval (CI): -4.68, 0.15]. Associations with PM2.5 showed similar patterns in comparison with OPvDTT but of smaller magnitude. Lung clearance index (LCI) and TBFVL parameters did not show any clear association with the exposures considered. At 3 y, increased frequency-dependent resistance of the lungs (Rrs7-19) from AOS tended to be associated with higher OPvDTT (β=0.09 hPa×s/L; 95% CI: -0.06, 0.24) and OPvAA (IQR=1.14 nmol/min/m3; β=0.12 hPa×s/L; 95% CI: -0.04, 0.27) but not with PM2.5 (IQR=6.9 μg/m3; β=0.02 hPa×s/L; 95% CI: -0.13, 0.16). Results for FRC and Rrs7-19 remained similar in OP models adjusted on PM2.5.RESULTSIn neonates, an interquartile (IQR) increase in OPvDTT (0.89 nmol/min/m3) was associated with a decrease in functional residual capacity (FRC) measured by N2MBW [β=-2.26mL; 95% confidence interval (CI): -4.68, 0.15]. Associations with PM2.5 showed similar patterns in comparison with OPvDTT but of smaller magnitude. Lung clearance index (LCI) and TBFVL parameters did not show any clear association with the exposures considered. At 3 y, increased frequency-dependent resistance of the lungs (Rrs7-19) from AOS tended to be associated with higher OPvDTT (β=0.09 hPa×s/L; 95% CI: -0.06, 0.24) and OPvAA (IQR=1.14 nmol/min/m3; β=0.12 hPa×s/L; 95% CI: -0.04, 0.27) but not with PM2.5 (IQR=6.9 μg/m3; β=0.02 hPa×s/L; 95% CI: -0.13, 0.16). Results for FRC and Rrs7-19 remained similar in OP models adjusted on PM2.5.Prenatal exposure to OPvDTT was associated with several offspring lung function parameters over time, all related to lung volumes. https://doi.org/10.1289/EHP11155.DISCUSSIONPrenatal exposure to OPvDTT was associated with several offspring lung function parameters over time, all related to lung volumes. https://doi.org/10.1289/EHP11155.
Author Chartier, Ryan
Quentin, Joane
Uzu, Gaëlle
Gioria, Yoann
Darfeuil, Sophie
Lepeule, Johanna
Pin, Isabelle
Marsal, Anouk
Bayat, Sam
Siroux, Valérie
Borlaza, Lucille Joanna S.
Jaffrezo, Jean-Luc
Boudier, Anne
Elazzouzi, Rhabira
Slama, Rémy
Lyon-Caen, Sarah
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  givenname: Anouk
  orcidid: 0000-0003-0898-1467
  surname: Marsal
  fullname: Marsal, Anouk
  organization: Université Grenoble Alpes, Centre national de la recherche scientifique (CNRS), INRAE, IRD, INP-G, IGE (UMR 5001), Grenoble, France, Agence de l’environnement et de la Maîtrise de l’Energie, Angers, France
– sequence: 2
  givenname: Rémy
  surname: Slama
  fullname: Slama, Rémy
  organization: Team of Environmental Epidemiology Applied to the Development and Respiratory Health, Institute for Advanced Biosciences, Inserm U 1209, CNRS UMR 5309, Université Grenoble Alpes, 38000 Grenoble, France
– sequence: 3
  givenname: Sarah
  surname: Lyon-Caen
  fullname: Lyon-Caen, Sarah
  organization: Team of Environmental Epidemiology Applied to the Development and Respiratory Health, Institute for Advanced Biosciences, Inserm U 1209, CNRS UMR 5309, Université Grenoble Alpes, 38000 Grenoble, France
– sequence: 4
  givenname: Lucille Joanna S.
  surname: Borlaza
  fullname: Borlaza, Lucille Joanna S.
  organization: Université Grenoble Alpes, Centre national de la recherche scientifique (CNRS), INRAE, IRD, INP-G, IGE (UMR 5001), Grenoble, France
– sequence: 5
  givenname: Jean-Luc
  surname: Jaffrezo
  fullname: Jaffrezo, Jean-Luc
  organization: Université Grenoble Alpes, Centre national de la recherche scientifique (CNRS), INRAE, IRD, INP-G, IGE (UMR 5001), Grenoble, France
– sequence: 6
  givenname: Anne
  surname: Boudier
  fullname: Boudier, Anne
  organization: Team of Environmental Epidemiology Applied to the Development and Respiratory Health, Institute for Advanced Biosciences, Inserm U 1209, CNRS UMR 5309, Université Grenoble Alpes, 38000 Grenoble, France, Pediatric Department, CHU Grenoble Alpes, Grenoble, France
– sequence: 7
  givenname: Sophie
  surname: Darfeuil
  fullname: Darfeuil, Sophie
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– sequence: 8
  givenname: Rhabira
  surname: Elazzouzi
  fullname: Elazzouzi, Rhabira
  organization: Université Grenoble Alpes, Centre national de la recherche scientifique (CNRS), INRAE, IRD, INP-G, IGE (UMR 5001), Grenoble, France
– sequence: 9
  givenname: Yoann
  surname: Gioria
  fullname: Gioria, Yoann
  organization: Team of Environmental Epidemiology Applied to the Development and Respiratory Health, Institute for Advanced Biosciences, Inserm U 1209, CNRS UMR 5309, Université Grenoble Alpes, 38000 Grenoble, France
– sequence: 10
  givenname: Johanna
  surname: Lepeule
  fullname: Lepeule, Johanna
  organization: Team of Environmental Epidemiology Applied to the Development and Respiratory Health, Institute for Advanced Biosciences, Inserm U 1209, CNRS UMR 5309, Université Grenoble Alpes, 38000 Grenoble, France
– sequence: 11
  givenname: Ryan
  surname: Chartier
  fullname: Chartier, Ryan
  organization: RTI International, Research Triangle Park, North Carolina, USA
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  givenname: Isabelle
  surname: Pin
  fullname: Pin, Isabelle
  organization: Team of Environmental Epidemiology Applied to the Development and Respiratory Health, Institute for Advanced Biosciences, Inserm U 1209, CNRS UMR 5309, Université Grenoble Alpes, 38000 Grenoble, France, Pediatric Department, CHU Grenoble Alpes, Grenoble, France
– sequence: 13
  givenname: Joane
  surname: Quentin
  fullname: Quentin, Joane
  organization: Team of Environmental Epidemiology Applied to the Development and Respiratory Health, Institute for Advanced Biosciences, Inserm U 1209, CNRS UMR 5309, Université Grenoble Alpes, 38000 Grenoble, France, Department of Pulmonology and Physiology, CHU Grenoble Alpes, Grenoble, France
– sequence: 14
  givenname: Sam
  surname: Bayat
  fullname: Bayat, Sam
  organization: Department of Pulmonology and Physiology, CHU Grenoble Alpes, Grenoble, France, Université Grenoble Alpes, Inserm UA07 STOBE Laboratory, Grenoble, France
– sequence: 15
  givenname: Gaëlle
  surname: Uzu
  fullname: Uzu, Gaëlle
  organization: Université Grenoble Alpes, Centre national de la recherche scientifique (CNRS), INRAE, IRD, INP-G, IGE (UMR 5001), Grenoble, France
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  givenname: Valérie
  surname: Siroux
  fullname: Siroux, Valérie
  organization: Team of Environmental Epidemiology Applied to the Development and Respiratory Health, Institute for Advanced Biosciences, Inserm U 1209, CNRS UMR 5309, Université Grenoble Alpes, 38000 Grenoble, France
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Snippet Fine particulate matter (PM2.5) has been found to be detrimental to respiratory health of children, but few studies have examined the effects of prenatal PM2.5...
BACKGROUND: Fine particulate matter (PM 2:5) has been found to be detrimental to respiratory health of children, but few studies have examined the effects of...
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SubjectTerms Environmental Sciences
Human health and pathology
Life Sciences
Pulmonology and respiratory tract
Santé publique et épidémiologie
Title Prenatal Exposure to PM2.5 Oxidative Potential and Lung Function in Infants and Preschool- Age Children: A Prospective Study
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