Neuroimaging findings in 4342 hospitalized COVID‐19 subjects: A multicenter report from the United States and Europe

To determine the incidence of acute neuroimaging (NI) findings and comorbidities in the coronavirus disease of 2019 (COVID-19)-infected subjects in seven U.S. and four European hospitals. This is a retrospective study of COVID-19-positive subjects with the following inclusion criteria: age >18, l...

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Published in:Journal of neuroimaging Vol. 33; no. 5; pp. 752 - 763
Main Authors: Faro, Scott H., Manmatharayan, Arichena, Leiby, Benjamin, Jain, Neelu, Mohamed, Feroze B., Talekar, Kiran S., Doshi, Amish, Jambor, Ivan, Chang, Sanders, Finkelstein, Mark, Kremer, Stephane, Lersy, Francois, Lindgren, Brenden, Figueiredo, Nathalia M., Gerevini, Simonetta, Napolitano, Angela, Jain, Rajan, Dogra, Siddhanth, Pillai, Jay J., Ryan, Dan, Jager, Rolf, Carletti, Francesco, Mian, Asim, Kaliev, Artem, Anand, Pria, Takahashi, Courtney, Murat, Ak, Colen, Rivka, Mansueto, Giancarlo, Pizzini, Francesca
Format: Journal Article
Language:English
Published: United States Wiley Subscription Services, Inc 01.09.2023
Subjects:
Comorbidity
Complications
Coronary artery disease
Coronaviruses
COVID-19
Demographics
Diabetes
Diabetes mellitus
Encephalitis
Encephalomyelitis
Heart diseases
Hemorrhage
Hospitalization
Hypertension
Ischemia
Kidney diseases
Medical imaging
Neuroimaging
Neurological complications
Stroke
Substantia alba
Thromboembolism
Thrombosis
Viral diseases
United States > US
Europe
COVID-19
brain
neuroimaging
ISSN:1051-2284, 1552-6569, 1552-6569
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Summary:To determine the incidence of acute neuroimaging (NI) findings and comorbidities in the coronavirus disease of 2019 (COVID-19)-infected subjects in seven U.S. and four European hospitals. This is a retrospective study of COVID-19-positive subjects with the following inclusion criteria: age >18, lab-confirmed COVID-19 infection, and acute NI findings (NI+) attributed to COVID-19 on CT or MRI brain. NI+ and comorbidities in total hospitalized COVID-19-positive (TN) subjects were assessed. A total of 37,950 COVID-19-positive subjects were reviewed and 4342 underwent NI. NI+ incidence in subjects with NI was 10.1% (442/4342) including 7.9% (294/3701) in the United States and 22.8% (148/647) in Europe. NI+ incidence in TN was 1.16% (442/37,950). In NI (4342), incidence of ischemic stroke was 6.4% followed by intracranial hemorrhage (ICH) (3.8%), encephalitis (0.5%), sinus venous thrombosis (0.2%), and acute disseminated encephalomyelitis (ADEM) (0.2%). White matter involvement was seen in 57% of NI+. Hypertension was the most common comorbidity (54%) before cardiac disease (28.8%) and diabetes mellitus (27.7%). Cardiac disease (p < .025), diabetes (p < .014), and chronic kidney disease (p < .012) were more common in the United States. This multicenter, multinational study investigated the incidence and spectrum of NI+ in 37,950 hospitalized adult COVID-19 subjects including regional differences in incidences of NI+, associated comorbidities, and other demographics. NI+ incidence in TN was 1.16% including 0.95% in the United States and 2.09% in Europe. ICH, encephalitis, and ADEM were common in Europe, while ischemic strokes were more common in the United States. In this cohort, incidence and distribution of NI+ helped characterize the neurological complications of COVID-19.
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ISSN:1051-2284
1552-6569
1552-6569
DOI:10.1111/jon.13140