Complement system component 3 deficiency modulates the phenotypic profile of murine macrophages

[Display omitted] •The lack of C3 causes morphological alterations in peritoneal macrophages.•The lack of C3 increases the levels of CD11c in macrophages.•The lack of C3 affects the phagocytosis of iC3b-opsonized particles.•The lack of C3 reduces ROS production in TPA-treated macrophages.•The lack o...

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Bibliographic Details
Published in:	Cellular immunology Vol. 405-406; p. 104886
Main Authors:	Francisco da Silva, Tiago, Akemi Amamura, Thaís, Cordeiro Valadão, Iuri, Carvalho Carneiro, Milena, Morais Freitas, Vanessa, Paula Lepique, Ana, Isaac, Lourdes
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Inc 01.11.2024
Subjects:	Animals Antigens, Differentiation - immunology Antigens, Differentiation - metabolism C3 deficiency CD11 Antigens CD11c Antigen - metabolism Complement C3 - deficiency Complement C3 - genetics Complement C3 - immunology Complement C3 - metabolism Complement C5a - immunology Complement C5a - metabolism Complement system Macrophages Macrophages - immunology Macrophages - metabolism Macrophages, Peritoneal - immunology Macrophages, Peritoneal - metabolism Male Mice Mice, Inbred C57BL Mice, Knockout Phagocytosis Phenotype Reactive Oxygen Species - metabolism Tetradecanoylphorbol Acetate - pharmacology C3 Complement system C3 deficiency Macrophages
ISSN:	0008-8749, 1090-2163, 1090-2163
Online Access:	Get full text
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