Relevant Ongoing Clinical Trials to Investigate Local‐Regional Treatment Strategies for Peritoneal Surface Malignancies
ABSTRACT Background and Objectives The multimodal therapy of peritoneal metastases of common cancers (i.e. colorectal, gastric, and ovarian), including CRS plus HIPEC, is still subject to several clinical studies. Methods This paper presents the ongoing studies regarding HIPEC, as found on clinicalt...
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| Vydané v: | Journal of surgical oncology Ročník 130; číslo 6; s. 1349 - 1357 |
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| Hlavní autori: | , , |
| Médium: | Journal Article |
| Jazyk: | English |
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United States
Wiley Subscription Services, Inc
01.11.2024
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| ISSN: | 0022-4790, 1096-9098, 1096-9098 |
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| Abstract | ABSTRACT
Background and Objectives
The multimodal therapy of peritoneal metastases of common cancers (i.e. colorectal, gastric, and ovarian), including CRS plus HIPEC, is still subject to several clinical studies.
Methods
This paper presents the ongoing studies regarding HIPEC, as found on clinicaltrials.gov. The emphasis was set on Phase III recruiting trials, including the newest information from principal investigators who answered the call of the authors.
Results
Ninety trials have been identified, and the protocols of 15 studies have been presented in detail.
Conclusions
There are interesting ongoing trials investigating the role of CRS plus HIPEC. |
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| AbstractList | Background and ObjectivesThe multimodal therapy of peritoneal metastases of common cancers (i.e. colorectal, gastric, and ovarian), including CRS plus HIPEC, is still subject to several clinical studies.MethodsThis paper presents the ongoing studies regarding HIPEC, as found on clinicaltrials.gov. The emphasis was set on Phase III recruiting trials, including the newest information from principal investigators who answered the call of the authors.ResultsNinety trials have been identified, and the protocols of 15 studies have been presented in detail.ConclusionsThere are interesting ongoing trials investigating the role of CRS plus HIPEC. The multimodal therapy of peritoneal metastases of common cancers (i.e. colorectal, gastric, and ovarian), including CRS plus HIPEC, is still subject to several clinical studies. This paper presents the ongoing studies regarding HIPEC, as found on clinicaltrials.gov. The emphasis was set on Phase III recruiting trials, including the newest information from principal investigators who answered the call of the authors. Ninety trials have been identified, and the protocols of 15 studies have been presented in detail. There are interesting ongoing trials investigating the role of CRS plus HIPEC. ABSTRACT Background and Objectives The multimodal therapy of peritoneal metastases of common cancers (i.e. colorectal, gastric, and ovarian), including CRS plus HIPEC, is still subject to several clinical studies. Methods This paper presents the ongoing studies regarding HIPEC, as found on clinicaltrials.gov. The emphasis was set on Phase III recruiting trials, including the newest information from principal investigators who answered the call of the authors. Results Ninety trials have been identified, and the protocols of 15 studies have been presented in detail. Conclusions There are interesting ongoing trials investigating the role of CRS plus HIPEC. The multimodal therapy of peritoneal metastases of common cancers (i.e. colorectal, gastric, and ovarian), including CRS plus HIPEC, is still subject to several clinical studies.BACKGROUND AND OBJECTIVESThe multimodal therapy of peritoneal metastases of common cancers (i.e. colorectal, gastric, and ovarian), including CRS plus HIPEC, is still subject to several clinical studies.This paper presents the ongoing studies regarding HIPEC, as found on clinicaltrials.gov. The emphasis was set on Phase III recruiting trials, including the newest information from principal investigators who answered the call of the authors.METHODSThis paper presents the ongoing studies regarding HIPEC, as found on clinicaltrials.gov. The emphasis was set on Phase III recruiting trials, including the newest information from principal investigators who answered the call of the authors.Ninety trials have been identified, and the protocols of 15 studies have been presented in detail.RESULTSNinety trials have been identified, and the protocols of 15 studies have been presented in detail.There are interesting ongoing trials investigating the role of CRS plus HIPEC.CONCLUSIONSThere are interesting ongoing trials investigating the role of CRS plus HIPEC. |
| Author | Häusler, S. Blaj, S. Piso, P. |
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| Cites_doi | 10.3390/cancers13143430 10.1016/S1470-2045(20)30599-4 10.1001/jamasurg.2021.1642 10.1002/jso.21519 10.1245/s10434-023-13116-z 10.1200/JCO.22.02867 10.1200/JCO.2023.41.16_suppl.5510 10.3389/fmed.2023.1070362 10.1200/JCO.2003.04.187 10.1056/NEJMoa1708618 |
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| References_xml | – volume: 22 start-page: 256 issue: 2 year: 2021 end-page: 266 article-title: UNICANCER‐GI Group and BIG Renape Group. Cytoreductive Surgery Plus Hyperthermic Intraperitoneal Chemotherapy Versus Cytoreductive Surgery Alone for Colorectal Peritoneal Metastases (PRODIGE 7): A Multicentre, Randomised, Open‐Label, Phase 3 Trial publication-title: The Lancet Oncology – volume: 42 start-page: 146 issue: 2 year: 2024 end-page: 156 article-title: Effect of Hyperthermic Intraperitoneal Chemotherapy on Cytoreductive Surgery in Gastric Cancer With Synchronous Peritoneal Metastases: The Phase III GASTRIPEC‐I Trial publication-title: Journal of Clinical Oncology – volume: 156 start-page: 710 issue: 8 year: 2021 end-page: 720 article-title: Perioperative Systemic Therapy vs Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy Alone for Resectable Colorectal Peritoneal Metastases: A Phase 2 Randomized Clinical Trial publication-title: JAMA surgery – volume: 101 start-page: 457 issue: 6 year: 2010 end-page: 464 article-title: Cytoreductive Surgery Plus Hyperthermic Intraperitoneal Chemotherapy to Treat Gastric Cancer With Ascites and/or Peritoneal Carcinomatosis: Results From a Chinese Center publication-title: Journal of Surgical Oncology – volume: 10 year: 2023 article-title: First Experience with 224Radium‐labeled Microparticles (Radspherin®) After CRS‐HIPEC for Peritoneal Metastasis in Colorectal Cancer (A Phase 1 Study) publication-title: Frontiers in Medicine (Lausanne) – volume: 13 issue: 14 year: 2021 article-title: Preclinical In Vivo‐Models to Investigate HIPEC; Current Methodologies and Challenges publication-title: Cancers – volume: 21 start-page: 3737 issue: 20 year: 2003 end-page: 3743 article-title: Randomized Trial of Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy Versus Systemic Chemotherapy and Palliative Surgery in Patients With Peritoneal Carcinomatosis of Colorectal Cancer publication-title: Journal of Clinical Oncology – volume: 378 start-page: 230 issue: 3 year: 2018 end-page: 240 article-title: Hyperthermic Intraperitoneal Chemotherapy in Ovarian Cancer publication-title: New England Journal of Medicine – volume: 30 start-page: 2678 issue: 5 year: 2023 end-page: 2688 article-title: Perioperative Systemic Therapy Versus Cytoreductive Surgery and HIPEC Alone for Resectable Colorectal Peritoneal Metastases: Patient‐Reported Outcomes of a Randomized Phase II Trial publication-title: Annals of Surgical Oncology – ident: e_1_2_10_11_1 doi: 10.3390/cancers13143430 – ident: e_1_2_10_3_1 doi: 10.1016/S1470-2045(20)30599-4 – ident: e_1_2_10_8_1 doi: 10.1001/jamasurg.2021.1642 – ident: e_1_2_10_4_1 doi: 10.1002/jso.21519 – ident: e_1_2_10_9_1 doi: 10.1245/s10434-023-13116-z – ident: e_1_2_10_5_1 doi: 10.1200/JCO.22.02867 – ident: e_1_2_10_7_1 doi: 10.1200/JCO.2023.41.16_suppl.5510 – ident: e_1_2_10_10_1 doi: 10.3389/fmed.2023.1070362 – ident: e_1_2_10_2_1 doi: 10.1200/JCO.2003.04.187 – ident: e_1_2_10_6_1 doi: 10.1056/NEJMoa1708618 |
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Background and Objectives
The multimodal therapy of peritoneal metastases of common cancers (i.e. colorectal, gastric, and ovarian), including CRS... The multimodal therapy of peritoneal metastases of common cancers (i.e. colorectal, gastric, and ovarian), including CRS plus HIPEC, is still subject to... Background and ObjectivesThe multimodal therapy of peritoneal metastases of common cancers (i.e. colorectal, gastric, and ovarian), including CRS plus HIPEC,... |
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| SubjectTerms | Chemotherapy, Cancer, Regional Perfusion Clinical Trials as Topic Clinical Trials, Phase III as Topic Combined Modality Therapy Cytoreduction Surgical Procedures cytoreductive surgery Humans Hyperthermia, Induced Hyperthermic Intraperitoneal Chemotherapy ongoing studies Peritoneal Neoplasms - secondary Peritoneal Neoplasms - therapy Stomach Neoplasms - pathology |
| Title | Relevant Ongoing Clinical Trials to Investigate Local‐Regional Treatment Strategies for Peritoneal Surface Malignancies |
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