Prior vaccination promotes early activation of memory T cells and enhances immune responses during SARS-CoV-2 breakthrough infection

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection of vaccinated individuals is increasingly common but rarely results in severe disease, likely due to the enhanced potency and accelerated kinetics of memory immune responses. However, there have been few opportunities to rigorous...

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Bibliographic Details
Published in:	Nature immunology Vol. 24; no. 10; pp. 1711 - 1724
Main Authors:	Painter, Mark M., Johnston, Timothy S., Lundgreen, Kendall A., Santos, Jefferson J. S., Qin, Juliana S., Goel, Rishi R., Apostolidis, Sokratis A., Mathew, Divij, Fulmer, Bria, Williams, Justine C., McKeague, Michelle L., Pattekar, Ajinkya, Goode, Ahmad, Nasta, Sean, Baxter, Amy E., Giles, Josephine R., Skelly, Ashwin N., Felley, Laura E., McLaughlin, Maura, Weaver, Joellen, Kuthuru, Oliva, Dougherty, Jeanette, Adamski, Sharon, Long, Sherea, Kee, Macy, Clendenin, Cynthia, da Silva Antunes, Ricardo, Grifoni, Alba, Weiskopf, Daniela, Sette, Alessandro, Huang, Alexander C., Rader, Daniel J., Hensley, Scott E., Bates, Paul, Greenplate, Allison R., Wherry, E. John
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01.10.2023 Nature Publishing Group
Subjects:	631/250/2152/1566 631/250/2152/1566/1571 631/250/2152/2153/1291 631/250/590/2293 692/699/255/2514 Antigens Biomedical and Life Sciences Biomedicine CD8 antigen Cell activation Cell differentiation Coronaviruses COVID-19 Flow cytometry Immune response Immunological memory Immunology Infections Infectious Diseases Kinetics Lymphocytes Lymphocytes T Memory cells Severe acute respiratory syndrome coronavirus 2 Vaccine efficacy Vaccines
ISSN:	1529-2908, 1529-2916, 1529-2916
Online Access:	Get full text
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