Dopamine disruption and autism phenotypes in slc6a3−/− zebrafish: Behavioural and molecular insights

Dopamine plays a crucial role in regulating movement, motivation, attention, and emotions. Disruptions in dopamine metabolism have been linked to various psychiatric disorders, including autism spectrum disorder (ASD). In this study, we generated an slc6a3 knockout zebrafish model using the CRISPR-C...

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Bibliographic Details
Published in:	Progress in neuro-psychopharmacology & biological psychiatry Vol. 143; p. 111528
Main Authors:	Li, Wen, Zhang, Xiaocong, Niu, Xiaoyu, Qin, Nan, Kang, Lulu, Wang, Kai, Wang, Mingyong
Format:	Journal Article
Language:	English
Published:	England Elsevier Inc 20.12.2025
Subjects:	Autism spectrum disorder Behavioural analysis Dopamine dysfunction slc6a3 Zebrafish model AB mpf slc6a3 Behavioural analysis ARRIVE KO Zebrafish model HPLC-ECD IHC Autism spectrum disorder SD RNA-seq TH ANOVA Dopamine dysfunction IACUC qPCR SEM dpf DA ELISA ISH
ISSN:	0278-5846, 1878-4216, 1878-4216
Online Access:	Get full text
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