Autoimmune endocrine diseases

The endocrine system is interested by several autoimmune diseases, characterized by different impact and severity, according to the organs involved. Autoimmune thyroid disorders (i.e. Hashimoto's thyroiditis and Graves' disease) and type 1 diabetes mellitus are the most common autoimmune e...

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Bibliographic Details
Published in:Minerva endocrinologica Vol. 43; no. 3; p. 305
Main Authors: Ruggeri, Rosaria M, Giuffrida, Giuseppe, Campennì, Alfredo
Format: Journal Article
Language:English
Published: Italy 01.09.2018
Subjects:
Autoimmune Diseases - complications
Autoimmune Diseases - diagnosis
Autoimmune Diseases - genetics
Autoimmune Diseases - therapy
Comorbidity
Endocrine System Diseases - complications
Endocrine System Diseases - diagnosis
Endocrine System Diseases - genetics
Endocrine System Diseases - therapy
Genetic Predisposition to Disease
Humans
ISSN:1827-1634, 1827-1634
Online Access:Get more information
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Summary:The endocrine system is interested by several autoimmune diseases, characterized by different impact and severity, according to the organs involved. Autoimmune thyroid disorders (i.e. Hashimoto's thyroiditis and Graves' disease) and type 1 diabetes mellitus are the most common autoimmune endocrine disorders, while hypophysitis, adrenalitis (90% of cases of primary hypocortisolism or Addison's disease), POF and hypoparathyroidism represent quite rare conditions. Autoimmune endocrine diseases can also coexist in the same individuals and cluster in families. Some of these associations are nosologically codified in the so-called autoimmune polyglandular syndromes, but autoimmune endocrinopathies can also be accompanied by other non-endocrine autoimmune disorders (i.e. connective tissue, skin or gastrointestinal diseases). Pathophysiology generally results from a complex interplay among genetic predisposition and environmental/endogenous factors. In the diagnostic process, measurement of organ-specific autoantibodies, both with a causative role or as an epiphenomenon, is often fundamental and integrates the assessment of hormone axes and the targeted imaging studies.
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ISSN:1827-1634
1827-1634
DOI:10.23736/S0391-1977.17.02757-2