Division of labor within the DNA damage tolerance system reveals non-epistatic and clinically actionable targets for precision cancer medicine

Crosslink repair depends on the Fanconi anemia pathway and translesion synthesis polymerases that replicate over unhooked crosslinks. Translesion synthesis is regulated via ubiquitination of PCNA, and independently via translesion synthesis polymerase REV1. The division of labor between PCNA-ubiquit...

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Vydané v:	Nucleic acids research Ročník 50; číslo 13; s. 7420 - 7435
Hlavní autori:	Spanjaard, Aldo, Shah, Ronak, de Groot, Daniël, Buoninfante, Olimpia Alessandra, Morris, Ben, Lieftink, Cor, Pritchard, Colin, Zürcher, Lisa M, Ormel, Shirley, Catsman, Joyce J I, de Korte-Grimmerink, Renske, Siteur, Bjørn, Proost, Natalie, Boadum, Terry, van de Ven, Marieke, Song, Ji-Ying, Kreft, Maaike, van den Berk, Paul C M, Beijersbergen, Roderick L, Jacobs, Heinz
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England Oxford University Press 22.07.2022
Predmet:	Animals Cisplatin - therapeutic use DNA Damage DNA Repair DNA Replication DNA-Directed DNA Polymerase - metabolism Genome Integrity, Repair and Humans Mice Neoplasms - drug therapy Neoplasms - genetics Precision Medicine Proliferating Cell Nuclear Antigen - metabolism Ubiquitination
ISSN:	0305-1048, 1362-4962, 1362-4962
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