Division of labor within the DNA damage tolerance system reveals non-epistatic and clinically actionable targets for precision cancer medicine

Crosslink repair depends on the Fanconi anemia pathway and translesion synthesis polymerases that replicate over unhooked crosslinks. Translesion synthesis is regulated via ubiquitination of PCNA, and independently via translesion synthesis polymerase REV1. The division of labor between PCNA-ubiquit...

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Veröffentlicht in:	Nucleic acids research Jg. 50; H. 13; S. 7420 - 7435
Hauptverfasser:	Spanjaard, Aldo, Shah, Ronak, de Groot, Daniël, Buoninfante, Olimpia Alessandra, Morris, Ben, Lieftink, Cor, Pritchard, Colin, Zürcher, Lisa M, Ormel, Shirley, Catsman, Joyce J I, de Korte-Grimmerink, Renske, Siteur, Bjørn, Proost, Natalie, Boadum, Terry, van de Ven, Marieke, Song, Ji-Ying, Kreft, Maaike, van den Berk, Paul C M, Beijersbergen, Roderick L, Jacobs, Heinz
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Oxford University Press 22.07.2022
Schlagworte:	Animals Cisplatin - therapeutic use DNA Damage DNA Repair DNA Replication DNA-Directed DNA Polymerase - metabolism Genome Integrity, Repair and Humans Mice Neoplasms - drug therapy Neoplasms - genetics Precision Medicine Proliferating Cell Nuclear Antigen - metabolism Ubiquitination
ISSN:	0305-1048, 1362-4962, 1362-4962
Online-Zugang:	Volltext
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