Solid-Phase Extraction of Polybrominated Diphenyl Ethers in Human Plasma ? Comparison with an Open Column Extraction Method

A solid phase extraction (SPE) method in combination with silica gel cleanup to analyse tri-to heptabrominated diphenyl ethers in human plasma was validated. All congeners showed recoveries over 70% except for BDE #183, which showed recoveries around 45%. The method was tested on 21 individual plasm...

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Veröffentlicht in:Chromatographia Jg. 61; H. 1-2; S. 67 - 73
Hauptverfasser: Karlsson, M., Julander, A., van Bavel, B., Lindstr m, G.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Oxford Springer 01.01.2005
Schlagworte:
Analytical chemistry
Biological and medical sciences
Chemical and industrial products toxicology. Toxic occupational diseases
Chemistry
Chromatographic methods and physical methods associated with chromatography
Enviromental Science
Exact sciences and technology
Gas chromatographic methods
Kemi
Medical sciences
Miljövetenskap
NATURAL SCIENCES
NATURVETENSKAP
Toxicology
Various organic compounds
Trace analysis
Human
Solid phase extraction
Biological fluid
Chemical analysis
Coupled method
Flame retardant
Extraction column
Blood
Chemical enrichment
Blood plasma
Gas chromatography
Pollutant
Sample preparation
Extraction method
Mass spectrometry
Comparative study
mass spectrometry; Solid phase extraction; Column extraction; Polybrominated diphenyl ethers; Human plasma
Quantitative analysis
ISSN:0009-5893, 1612-1112, 1612-1112
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Zusammenfassung:A solid phase extraction (SPE) method in combination with silica gel cleanup to analyse tri-to heptabrominated diphenyl ethers in human plasma was validated. All congeners showed recoveries over 70% except for BDE #183, which showed recoveries around 45%. The method was tested on 21 individual plasma samples which were extracted with both the SPE method and an open column extraction method using Hydromatrix. Method detection limits were of the same order of magnitude for both methods, ranging from 0.0076 to 0.13 ng g −1 (l.w.) depending on the congener. The SPE extraction method meets the demand for a faster, less solvent-and sample-demanding method with lower contamination risk due to fewer steps compared to the open column extraction.
ISSN:0009-5893
1612-1112
1612-1112
DOI:10.1365/s10337-004-0461-z