The Concise Guide to PHARMACOLOGY 2023/24: Introduction and Other Protein Targets
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands. There is an emphasis...
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| Vydané v: | British journal of pharmacology Ročník 180; číslo S2; s. S1 - S22 |
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| Hlavní autori: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | English |
| Vydavateľské údaje: |
England
01.10.2023
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| ISSN: | 0007-1188, 1476-5381, 1476-5381 |
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| Abstract | The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes almost 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point‐in‐time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.16176. In addition to this overview, in which are identified ‘Other protein targets’ which fall outside of the subsequent categorisation, there are six areas of focus: G protein‐coupled receptors, ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid‐2023, and supersedes data presented in the 2021/22, 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC‐IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate. |
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| AbstractList | The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes almost 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.16176. In addition to this overview, in which are identified 'Other protein targets' which fall outside of the subsequent categorisation, there are six areas of focus: G protein-coupled receptors, ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2023, and supersedes data presented in the 2021/22, 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate. The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands ( www.guidetopharmacology.org ), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes almost 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point‐in‐time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.16176 . In addition to this overview, in which are identified ‘Other protein targets’ which fall outside of the subsequent categorisation, there are six areas of focus: G protein‐coupled receptors, ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid‐2023, and supersedes data presented in the 2021/22, 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC‐IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate. The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes almost 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.16176. In addition to this overview, in which are identified 'Other protein targets' which fall outside of the subsequent categorisation, there are six areas of focus: G protein-coupled receptors, ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2023, and supersedes data presented in the 2021/22, 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes almost 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.16176. In addition to this overview, in which are identified 'Other protein targets' which fall outside of the subsequent categorisation, there are six areas of focus: G protein-coupled receptors, ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2023, and supersedes data presented in the 2021/22, 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate. |
| Author | Sutton, Laurie Hepler, John R. Alexander, Stephen P. H. Ogujiofor, Osita Layeghi‐Ghalehsoukhteh, Somayeh Spedding, Michael Armstrong, Jane F. Sobey, Christopher Montañez‐Miranda, Carolina Mathie, Alistair A. Ahlers‐Dannen, Katelin E. Druey, Kirk M. Choudhuri, Shreoshi P. Davies, Jamie A. Zhang, Qian Fisher, Rory A. Bodle, Christopher Peters, John A. Sjogren, Benita Buneman, O. Peter Veale, Emma L. Kantheti, Havish S. Mascarenhas, Luke D. Shaw, Vincent Wendimu, Menbere Martemyanov, Kirill Spicer, Mackenzie M. Alqinyah, Mohammed Karaj, Behirda Phan, Hoa Arumugam, Thiruma V. Faccenda, Elena Xie, Keqiang Davenport, Anthony P. Zolghadri, Yalda Chakravarti, Bandana Lee, Jae‐Kyung Kelly, Eamonn Striessnig, Jörg McNabb, Harrison Wilkie, Thomas Roman, David L. Fabbro, Doriano Squires, Katherine E. Dagner, Josephine Buo Hooks, Shelley B. Cidlowski, John A. Gerber, Kyle J. Luo, Zili Harding, Simon D. |
| Author_xml | – sequence: 1 givenname: Stephen P. H. orcidid: 0000-0003-4417-497X surname: Alexander fullname: Alexander, Stephen P. H. organization: University of Nottingham Medical School – sequence: 2 givenname: Eamonn surname: Kelly fullname: Kelly, Eamonn organization: University of Bristol – sequence: 3 givenname: Alistair A. orcidid: 0000-0001-6094-2890 surname: Mathie fullname: Mathie, Alistair A. organization: University of Suffolk – sequence: 4 givenname: John A. orcidid: 0000-0002-4277-4245 surname: Peters fullname: Peters, John A. organization: University of Dundee – sequence: 5 givenname: Emma L. orcidid: 0000-0002-6778-9929 surname: Veale fullname: Veale, Emma L. organization: The Universities of Greenwich and Kent at Medway – sequence: 6 givenname: Jane F. orcidid: 0000-0002-0524-0260 surname: Armstrong fullname: Armstrong, Jane F. organization: University of Edinburgh – sequence: 7 givenname: O. Peter surname: Buneman fullname: Buneman, O. Peter organization: University of Edinburgh – sequence: 8 givenname: Elena orcidid: 0000-0001-9855-7103 surname: Faccenda fullname: Faccenda, Elena organization: University of Edinburgh – sequence: 9 givenname: Simon D. orcidid: 0000-0002-9262-8318 surname: Harding fullname: Harding, Simon D. organization: University of Edinburgh – sequence: 10 givenname: Michael orcidid: 0000-0002-1248-8221 surname: Spedding fullname: Spedding, Michael organization: Spedding Research Solutions SARL – sequence: 11 givenname: John A. orcidid: 0000-0003-1420-0516 surname: Cidlowski fullname: Cidlowski, John A. organization: National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services – sequence: 12 givenname: Doriano orcidid: 0000-0002-9400-4517 surname: Fabbro fullname: Fabbro, Doriano organization: PIQUR Therapeutics – sequence: 13 givenname: Anthony P. orcidid: 0000-0002-2096-3117 surname: Davenport fullname: Davenport, Anthony P. organization: University of Cambridge – sequence: 14 givenname: Jörg orcidid: 0000-0002-9406-7120 surname: Striessnig fullname: Striessnig, Jörg organization: University of Innsbruck – sequence: 15 givenname: Jamie A. orcidid: 0000-0001-6660-4032 surname: Davies fullname: Davies, Jamie A. organization: University of Edinburgh – sequence: 16 givenname: Katelin E. surname: Ahlers‐Dannen fullname: Ahlers‐Dannen, Katelin E. organization: University of Iowa – sequence: 17 givenname: Mohammed surname: Alqinyah fullname: Alqinyah, Mohammed organization: University of Georgia – sequence: 18 givenname: Thiruma V. surname: Arumugam fullname: Arumugam, Thiruma V. organization: National University of Singapore – sequence: 19 givenname: Christopher surname: Bodle fullname: Bodle, Christopher organization: University of Pittsburgh – sequence: 20 givenname: Josephine Buo surname: Dagner fullname: Dagner, Josephine Buo organization: University of Georgia – sequence: 21 givenname: Bandana surname: Chakravarti fullname: Chakravarti, Bandana organization: University of Iowa – sequence: 22 givenname: Shreoshi P. surname: Choudhuri fullname: Choudhuri, Shreoshi P. organization: University of Texas Southwestern Medical Center – sequence: 23 givenname: Kirk M. surname: Druey fullname: Druey, Kirk M. organization: National Institute of Health – sequence: 24 givenname: Rory A. surname: Fisher fullname: Fisher, Rory A. organization: University of Iowa – sequence: 25 givenname: Kyle J. surname: Gerber fullname: Gerber, Kyle J. organization: Tetracore Inc – sequence: 26 givenname: John R. surname: Hepler fullname: Hepler, John R. organization: Emory University – sequence: 27 givenname: Shelley B. surname: Hooks fullname: Hooks, Shelley B. organization: University of Georgia – sequence: 28 givenname: Havish S. surname: Kantheti fullname: Kantheti, Havish S. organization: University of Texas Southwestern Medical Center – sequence: 29 givenname: Behirda surname: Karaj fullname: Karaj, Behirda organization: University of Michigan – sequence: 30 givenname: Somayeh surname: Layeghi‐Ghalehsoukhteh fullname: Layeghi‐Ghalehsoukhteh, Somayeh organization: Cobel Darou – sequence: 31 givenname: Jae‐Kyung surname: Lee fullname: Lee, Jae‐Kyung organization: University of Georgia – sequence: 32 givenname: Zili surname: Luo fullname: Luo, Zili organization: University of Iowa – sequence: 33 givenname: Kirill surname: Martemyanov fullname: Martemyanov, Kirill organization: Scripps Research Institute – sequence: 34 givenname: Luke D. surname: Mascarenhas fullname: Mascarenhas, Luke D. organization: University of Texas Southwestern Medical Center – sequence: 35 givenname: Harrison surname: McNabb fullname: McNabb, Harrison organization: Purdue University – sequence: 36 givenname: Carolina surname: Montañez‐Miranda fullname: Montañez‐Miranda, Carolina organization: Emory University – sequence: 37 givenname: Osita surname: Ogujiofor fullname: Ogujiofor, Osita organization: University of Texas Southwestern Medical Center – sequence: 38 givenname: Hoa surname: Phan fullname: Phan, Hoa organization: University of Michigan – sequence: 39 givenname: David L. surname: Roman fullname: Roman, David L. organization: University of Iowa – sequence: 40 givenname: Vincent surname: Shaw fullname: Shaw, Vincent organization: Michigan State University – sequence: 41 givenname: Benita orcidid: 0000-0003-1460-1045 surname: Sjogren fullname: Sjogren, Benita organization: Purdue University – sequence: 42 givenname: Christopher orcidid: 0000-0001-6525-9097 surname: Sobey fullname: Sobey, Christopher organization: La Trobe University – sequence: 43 givenname: Mackenzie M. surname: Spicer fullname: Spicer, Mackenzie M. organization: University of Iowa – sequence: 44 givenname: Katherine E. surname: Squires fullname: Squires, Katherine E. organization: Emory University – sequence: 45 givenname: Laurie surname: Sutton fullname: Sutton, Laurie organization: University of Maryland – sequence: 46 givenname: Menbere surname: Wendimu fullname: Wendimu, Menbere organization: University of Georgia – sequence: 47 givenname: Thomas surname: Wilkie fullname: Wilkie, Thomas organization: University of Texas Southwestern Medical Center – sequence: 48 givenname: Keqiang surname: Xie fullname: Xie, Keqiang organization: Scripps Research Institute – sequence: 49 givenname: Qian surname: Zhang fullname: Zhang, Qian organization: Purdue University – sequence: 50 givenname: Yalda surname: Zolghadri fullname: Zolghadri, Yalda organization: University of Texas Southwestern Medical Center |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/38123153$$D View this record in MEDLINE/PubMed |
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| ContentType | Journal Article |
| Copyright | 2023 The Authors. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of The British Pharmacological Society 2023 The Authors. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of The British Pharmacological Society. |
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