Dark‐field hyperspectral imaging for label free detection of nano‐bio‐materials

Nanomaterials are playing an increasingly important role in cancer diagnosis and treatment. Nanoparticle (NP)‐based technologies have been utilized for targeted drug delivery during chemotherapies, photodynamic therapy, and immunotherapy. Another active area of research is the toxicity studies of th...

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Vydané v:Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Ročník 13; číslo 1; s. e1661 - n/a
Hlavní autori: Mehta, Nishir, Sahu, Sushant P., Shaik, Shahensha, Devireddy, Ram, Gartia, Manas Ranjan
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Hoboken, USA John Wiley & Sons, Inc 01.01.2021
Wiley Subscription Services, Inc
Predmet:
Biocompatibility
Diagnostic software
Diagnostic systems
Drug delivery
Fourier analysis
Fourier transforms
Hyperspectral imaging
hyperspectral microscopy
Immunotherapy
In vivo methods and tests
Infrared analysis
label‐free imaging
Mass spectrometry
Mass spectroscopy
Medical imaging
Microbiology
Microorganisms
Microscopy
Nanomaterials
Nanoparticles
Nanotechnology
Photodynamic therapy
plasmonics
Proteins
Raman spectroscopy
Sample preparation
Spectroscopy
Surgery
Surgical equipment
Surgical instruments
Toxicity
Transmission electron microscopy
tumor diagnostics
ISSN:1939-5116, 1939-0041, 1939-0041
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Popis
Shrnutí:Nanomaterials are playing an increasingly important role in cancer diagnosis and treatment. Nanoparticle (NP)‐based technologies have been utilized for targeted drug delivery during chemotherapies, photodynamic therapy, and immunotherapy. Another active area of research is the toxicity studies of these nanomaterials to understand the cellular uptake and transport of these materials in cells, tissues, and environment. Traditional techniques such as transmission electron microscopy, and mass spectrometry to analyze NP‐based cellular transport or toxicity effect are expensive, require extensive sample preparation, and are low‐throughput. Dark‐field hyperspectral imaging (DF‐HSI), an integration of spectroscopy and microscopy/imaging, provides the ability to investigate cellular transport of these NPs and to quantify the distribution of them within bio‐materials. DF‐HSI also offers versatility in non‐invasively monitoring microorganisms, single cell, and proteins. DF‐HSI is a low‐cost, label‐free technique that is minimally invasive and is a viable choice for obtaining high‐throughput quantitative molecular analyses. Multimodal imaging modalities such as Fourier transform infrared and Raman spectroscopy are also being integrated with HSI systems to enable chemical imaging of the samples. HSI technology is being applied in surgeries to obtain molecular information about the tissues in real‐time. This article provides brief overview of fundamental principles of DF‐HSI and its application for nanomaterials, protein‐detection, single‐cell analysis, microbiology, surgical procedures along with technical challenges and future integrative approach with other imaging and measurement modalities. This article is categorized under: Diagnostic Tools > in vitro Nanoparticle‐Based Sensing Diagnostic Tools > in vivo Nanodiagnostics and Imaging Implantable Materials and Surgical Technologies > Nanoscale Tools and Techniques in Surgery Versatile use of dark‐field hyperspectral imaging for detecting transport of nanomaterials in cells and tissues and for cancer diagnostics.
Bibliografia:Funding information
Nishir Mehta and Sushant Sahu contributed equally to this work.
Louisiana Board of Regents, Grant/Award Number: LEQSF (2017‐20)‐RD‐A‐04; Louisiana State University Start up fund
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ISSN:1939-5116
1939-0041
1939-0041
DOI:10.1002/wnan.1661