(Non-)translational medicine: targeting bacterial RNA
The rise and spread of antibiotic resistance is among the most severe challenges facing modern medicine. Despite this fact, attempts to develop novel classes of antibiotic have been largely unsuccessful. The traditional mechanisms by which antibiotics work are subject to relatively rapid bacterial r...
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| Veröffentlicht in: | Frontiers in genetics Jg. 4; S. 230 |
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| Abstract | The rise and spread of antibiotic resistance is among the most severe challenges facing modern medicine. Despite this fact, attempts to develop novel classes of antibiotic have been largely unsuccessful. The traditional mechanisms by which antibiotics work are subject to relatively rapid bacterial resistance via mutation, and hence have a limited period of efficacy. One promising strategy to ameliorate this problem is to shift from the use of chemical compounds targeting protein structures and processes to a new era of RNA-based therapeutics. RNA-mediated regulation (riboregulation) has evolved naturally in bacteria and is therefore a highly efficient means by which gene expression can be manipulated. Here, we describe recent advances toward the development of effective anti-bacterial therapies, which operate through various strategies centered on RNA. |
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| AbstractList | The rise and spread of antibiotic resistance is among the most severe challenges facing modern medicine. Despite this fact, attempts to develop novel classes of antibiotic have been largely unsuccessful. The traditional mechanisms by which antibiotics work are subject to relatively rapid bacterial resistance via mutation, and hence have a limited period of efficacy. One promising strategy to ameliorate this problem is to shift from the use of chemical compounds targeting protein structures and processes to a new era of RNA-based therapeutics. RNA-mediated regulation (riboregulation) has evolved naturally in bacteria and is therefore a highly efficient means by which gene expression can be manipulated. Here, we describe recent advances toward the development of effective anti-bacterial therapies, which operate through various strategies centered on RNA.The rise and spread of antibiotic resistance is among the most severe challenges facing modern medicine. Despite this fact, attempts to develop novel classes of antibiotic have been largely unsuccessful. The traditional mechanisms by which antibiotics work are subject to relatively rapid bacterial resistance via mutation, and hence have a limited period of efficacy. One promising strategy to ameliorate this problem is to shift from the use of chemical compounds targeting protein structures and processes to a new era of RNA-based therapeutics. RNA-mediated regulation (riboregulation) has evolved naturally in bacteria and is therefore a highly efficient means by which gene expression can be manipulated. Here, we describe recent advances toward the development of effective anti-bacterial therapies, which operate through various strategies centered on RNA. The rise and spread of antibiotic resistance is among the most severe challenges facing modern medicine. Despite this fact, attempts to develop novel classes of antibiotic have been largely unsuccessful. The traditional mechanisms by which antibiotics work are subject to relatively rapid bacterial resistance via mutation, and hence have a limited period of efficacy. One promising strategy to ameliorate this problem is to shift from the use of chemical compounds targeting protein structures and processes to a new era of RNA-based therapeutics. RNA-mediated regulation (riboregulation) has evolved naturally in bacteria and is therefore a highly efficient means by which gene expression can be manipulated. Here, we describe recent advances toward the development of effective anti-bacterial therapies, which operate through various strategies centered on RNA. |
| Author | Loftus, Brendan J. Dinan, Adam M. |
| AuthorAffiliation | School of Medicine and Medical Science, Conway Institute of Biomolecular and Biomedical Research, University College Dublin Dublin, Ireland |
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| Copyright | Copyright © 2013 Dinan and Loftus. 2013 |
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| Keywords | riboswitch bacteria locked nucleic acids non-coding RNA small RNA antibiotics antisense external guide sequence |
| Language | English |
| License | This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Edited by: William Cho, Queen Elizabeth Hospital, Hong Kong This article was submitted to Non-Coding RNA, a section of the journal Frontiers in Genetics. Reviewed by: Aaron J. Schetter, National Cancer Institute, USA; Bing Yao, Emory University, USA |
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| References | 23651005 - ACS Synth Biol. 2012 Jan 20;1(1):6-13 23478298 - Cell Res. 2013 Jun;23(6):733-4 23360965 - Nat Biotechnol. 2013 Mar;31(3):233-9 11926811 - Biochemistry. 2002 Apr 9;41(14):4503-10 23730301 - Front Microbiol. 2013 May 17;4:121 16980936 - Nat Rev Microbiol. 2006 Oct;4(10):729-40 15908386 - Infect Immun. 2005 Jun;73(6):3568-76 17143270 - Nat Chem Biol. 2007 Jan;3(1):44-9 17160062 - Nat Biotechnol. 2006 Dec;24(12):1558-64 12464185 - Cell. 2002 Nov 27;111(5):747-56 23287722 - Science. 2013 Feb 15;339(6121):823-6 9830149 - Lett Appl Microbiol. 1998 Nov;27(5):297-301 19433567 - Antimicrob Agents Chemother. 2009 Jul;53(7):2871-8 20421948 - PLoS Pathog. 2010 Apr 22;6(4):e1000865 23047683 - Nat Commun. 2012;3:1125 20707673 - Annu Rev Genet. 2010;44:167-88 23393193 - Nucleic Acids Res. 2013 Apr 1;41(6):3787-804 24111714 - FEMS Microbiol Lett. 2013 Dec;349(1):25-31 23287718 - Science. 2013 Feb 15;339(6121):819-23 22274956 - RNA. 2012 Mar;18(3):590-602 23584588 - Nature. 2013 May 9;497(7448):254-7 21455174 - Nature. 2011 Mar 31;471(7340):602-7 22546938 - RNA Biol. 2012 Apr;9(4):427-36 17379808 - Science. 2007 Mar 23;315(5819):1709-12 20211282 - N Biotechnol. 2010 Jul 31;27(3):212-21 22858676 - RNA Biol. 2012 Aug;9(8):1039-44 21593602 - RNA Biol. 2011 Jul-Aug;8(4):674-80 19239884 - Cell. 2009 Feb 20;136(4):615-28 7479948 - Proc Natl Acad Sci U S A. 1995 Nov 21;92(24):11115-9 15616302 - Antimicrob Agents Chemother. 2005 Jan;49(1):249-55 9241234 - Nucleic Acids Res. 1997 Aug 15;25(16):3218-27 19739679 - ACS Chem Biol. 2009 Nov 20;4(11):915-27 1373488 - Proc Natl Acad Sci U S A. 1992 Apr 15;89(8):3185-9 18263737 - Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2354-7 19004840 - J Antimicrob Chemother. 2009 Feb;63(2):225-9 12323379 - Chem Biol. 2002 Sep;9(9):1043 23138594 - ACS Chem Biol. 2013 Feb 15;8(2):360-7 16356850 - Chem Biol. 2005 Dec;12(12):1325-35 23563642 - RNA Biol. 2013 May;10(5):726-37 16968952 - Pharmacol Rev. 2006 Sep;58(3):621-81 21760622 - Nat Rev Microbiol. 2011 Aug 15;9(8):578-89 17079242 - J Antimicrob Chemother. 2007 Jan;59(1):66-73 11283595 - Nat Biotechnol. 2001 Apr;19(4):360-4 14987762 - FEMS Microbiol Lett. 2004 Feb 16;231(2):177-84 20056882 - Science. 2010 Jan 8;327(5962):167-70 23495939 - Annu Rev Biochem. 2013;82:237-66 21296758 - Nucleic Acids Res. 2011 Apr;39(8):e50 12676109 - Curr Biol. 2003 Apr 1;13(7):R285-91 11021941 - Microbiology. 2000 Oct;146 ( Pt 10):2665-70 23525464 - Nucleic Acids Res. 2013 May 1;41(10):e106 19015356 - Antimicrob Agents Chemother. 2009 Feb;53(2):525-30 10611727 - Ocul Immunol Inflamm. 1999 Dec;7(3-4):189-98 23332744 - Cell. 2013 Jan 17;152(1-2):17-24 14506035 - Antimicrob Agents Chemother. 2003 Oct;47(10):3233-9 20220305 - RNA Biol. 2010 Mar-Apr;7(2):140-4 21925377 - Mol Cell. 2011 Sep 16;43(6):880-91 17534267 - Mol Ther. 2007 Aug;15(8):1537-42 20438352 - J Infect Dis. 2010 Jun 15;201(12):1822-30 19444248 - Nat Rev Microbiol. 2009 Jun;7(6):460-6 23727592 - Int J Pharm. 2013 Sep 10;453(2):651-5 15914490 - J Antimicrob Chemother. 2005 Jul;56(1):97-103 22985881 - Antimicrob Agents Chemother. 2012 Dec;56(12):6147-53 23515318 - Biores Open Access. 2012 Oct;1(5):260-3 22949671 - Proc Natl Acad Sci U S A. 2012 Sep 25;109(39):E2579-86 11381134 - Proc Natl Acad Sci U S A. 2001 Jun 5;98(12):6605-10 19666539 - Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13230-5 |
| References_xml | – reference: 23730301 - Front Microbiol. 2013 May 17;4:121 – reference: 14506035 - Antimicrob Agents Chemother. 2003 Oct;47(10):3233-9 – reference: 15908386 - Infect Immun. 2005 Jun;73(6):3568-76 – reference: 10611727 - Ocul Immunol Inflamm. 1999 Dec;7(3-4):189-98 – reference: 11021941 - Microbiology. 2000 Oct;146 ( Pt 10):2665-70 – reference: 15914490 - J Antimicrob Chemother. 2005 Jul;56(1):97-103 – reference: 23525464 - Nucleic Acids Res. 2013 May 1;41(10):e106 – reference: 20056882 - Science. 2010 Jan 8;327(5962):167-70 – reference: 23047683 - Nat Commun. 2012;3:1125 – reference: 23651005 - ACS Synth Biol. 2012 Jan 20;1(1):6-13 – reference: 23287718 - Science. 2013 Feb 15;339(6121):819-23 – reference: 19666539 - Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13230-5 – reference: 17079242 - J Antimicrob Chemother. 2007 Jan;59(1):66-73 – reference: 24111714 - FEMS Microbiol Lett. 2013 Dec;349(1):25-31 – reference: 21593602 - RNA Biol. 2011 Jul-Aug;8(4):674-80 – reference: 21455174 - Nature. 2011 Mar 31;471(7340):602-7 – reference: 20421948 - PLoS Pathog. 2010 Apr 22;6(4):e1000865 – reference: 23332744 - Cell. 2013 Jan 17;152(1-2):17-24 – reference: 17534267 - Mol Ther. 2007 Aug;15(8):1537-42 – reference: 21296758 - Nucleic Acids Res. 2011 Apr;39(8):e50 – reference: 22546938 - RNA Biol. 2012 Apr;9(4):427-36 – reference: 16968952 - Pharmacol Rev. 2006 Sep;58(3):621-81 – reference: 11283595 - Nat Biotechnol. 2001 Apr;19(4):360-4 – reference: 17143270 - Nat Chem Biol. 2007 Jan;3(1):44-9 – reference: 23360965 - Nat Biotechnol. 2013 Mar;31(3):233-9 – reference: 22949671 - Proc Natl Acad Sci U S A. 2012 Sep 25;109(39):E2579-86 – reference: 16980936 - Nat Rev Microbiol. 2006 Oct;4(10):729-40 – reference: 12323379 - Chem Biol. 2002 Sep;9(9):1043 – reference: 19239884 - Cell. 2009 Feb 20;136(4):615-28 – reference: 17160062 - Nat Biotechnol. 2006 Dec;24(12):1558-64 – reference: 22985881 - Antimicrob Agents Chemother. 2012 Dec;56(12):6147-53 – reference: 21760622 - Nat Rev Microbiol. 2011 Aug 15;9(8):578-89 – reference: 19004840 - J Antimicrob Chemother. 2009 Feb;63(2):225-9 – reference: 23478298 - Cell Res. 2013 Jun;23(6):733-4 – reference: 20220305 - RNA Biol. 2010 Mar-Apr;7(2):140-4 – reference: 20211282 - N Biotechnol. 2010 Jul 31;27(3):212-21 – reference: 22858676 - RNA Biol. 2012 Aug;9(8):1039-44 – reference: 23727592 - Int J Pharm. 2013 Sep 10;453(2):651-5 – reference: 23495939 - Annu Rev Biochem. 2013;82:237-66 – reference: 22274956 - RNA. 2012 Mar;18(3):590-602 – reference: 19444248 - Nat Rev Microbiol. 2009 Jun;7(6):460-6 – reference: 23138594 - ACS Chem Biol. 2013 Feb 15;8(2):360-7 – reference: 12676109 - Curr Biol. 2003 Apr 1;13(7):R285-91 – reference: 11926811 - Biochemistry. 2002 Apr 9;41(14):4503-10 – reference: 19015356 - Antimicrob Agents Chemother. 2009 Feb;53(2):525-30 – reference: 19739679 - ACS Chem Biol. 2009 Nov 20;4(11):915-27 – reference: 23515318 - Biores Open Access. 2012 Oct;1(5):260-3 – reference: 21925377 - Mol Cell. 2011 Sep 16;43(6):880-91 – reference: 16356850 - Chem Biol. 2005 Dec;12(12):1325-35 – reference: 20707673 - Annu Rev Genet. 2010;44:167-88 – reference: 23584588 - Nature. 2013 May 9;497(7448):254-7 – reference: 9830149 - Lett Appl Microbiol. 1998 Nov;27(5):297-301 – reference: 23287722 - Science. 2013 Feb 15;339(6121):823-6 – reference: 23563642 - RNA Biol. 2013 May;10(5):726-37 – reference: 20438352 - J Infect Dis. 2010 Jun 15;201(12):1822-30 – reference: 9241234 - Nucleic Acids Res. 1997 Aug 15;25(16):3218-27 – reference: 14987762 - FEMS Microbiol Lett. 2004 Feb 16;231(2):177-84 – reference: 17379808 - Science. 2007 Mar 23;315(5819):1709-12 – reference: 19433567 - Antimicrob Agents Chemother. 2009 Jul;53(7):2871-8 – reference: 12464185 - Cell. 2002 Nov 27;111(5):747-56 – reference: 11381134 - Proc Natl Acad Sci U S A. 2001 Jun 5;98(12):6605-10 – reference: 7479948 - Proc Natl Acad Sci U S A. 1995 Nov 21;92(24):11115-9 – reference: 15616302 - Antimicrob Agents Chemother. 2005 Jan;49(1):249-55 – reference: 18263737 - Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2354-7 – reference: 1373488 - Proc Natl Acad Sci U S A. 1992 Apr 15;89(8):3185-9 – reference: 23393193 - Nucleic Acids Res. 2013 Apr 1;41(6):3787-804 |
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| Title | (Non-)translational medicine: targeting bacterial RNA |
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