Specific Hepatic Sphingolipids Relate to Insulin Resistance, Oxidative Stress, and Inflammation in Nonalcoholic Steatohepatitis

Insulin resistance and nonalcoholic fatty liver disease have been linked to several lipid metabolites in animals, but their role in humans remains unclear. This study examined the relationship of sphingolipids with hepatic and peripheral metabolism in 21 insulin-resistant obese patients without (NAF...

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Bibliographic Details
Published in:	Diabetes care Vol. 41; no. 6; p. 1235
Main Authors:	Apostolopoulou, Maria, Gordillo, Ruth, Koliaki, Chrysi, Gancheva, Sofia, Jelenik, Tomas, De Filippo, Elisabetta, Herder, Christian, Markgraf, Daniel, Jankowiak, Frank, Esposito, Irene, Schlensak, Matthias, Scherer, Philipp E, Roden, Michael
Format:	Journal Article
Language:	English
Published:	United States 01.06.2018
Subjects:	Adult Animals Disease Progression Female Glucose Clamp Technique Humans Inflammation - blood Inflammation - metabolism Inflammation - physiopathology Insulin Resistance - physiology Lipid Peroxidation - physiology Liver - chemistry Liver - metabolism Liver - pathology Male Middle Aged Non-alcoholic Fatty Liver Disease - blood Non-alcoholic Fatty Liver Disease - metabolism Non-alcoholic Fatty Liver Disease - physiopathology Obesity - blood Obesity - metabolism Obesity - physiopathology Obesity - surgery Oxidation-Reduction Oxidative Stress - physiology Prospective Studies Sphingolipids - analysis Sphingolipids - blood Sphingolipids - metabolism
ISSN:	1935-5548, 1935-5548
Online Access:	Get more information
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